ANTI-DIABETIC AND HYPOLIPIDEMIC ACTIVITY OF FRUITS OF PYRUS COMMUNIS L. IN HYPERGLYCEMIC RATS

Abstract

Objective: To evaluate the hypoglycemic and hypolipidemic effect of ethyl acetate (EAEPC) and ethanolic (EEPC) extracts from fruits of Pyrus communis by dexamethasone-induced diabetic rats.

Methods: The different groups of animals were induced for diabetes with dexamethasone (10 mg/kg bw- sc) once daily for 11 days except normal control. The extracts 200mg/kg and glibenclamide 5mg/kg was administered to treat the diabetic rats once daily for 11 days.

Results: The treated groups showed significant (p<0.01) anti-diabetic and hypolipidemic activity as compared to diabetic control. The extracts show beneficial effects on blood glucose like as standard. It also reduces the elevated biochemical parameters such as triglycerides (TGL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and total cholesterol (TC), increased the reduced level of high density lipoprotein (HDL) and maintains body weight.

Conclusion: The both extracts could serve as good oral hypoglycemic agents and seems to be promising for the development of phytomedicines for diabetes mellitus and its complications.

Key words: Anti-diabetic, Hypolipidemic, Pyrus communis, Dexamethasone and Glibenclamide.