STUDIES ON ANTICONVULSANT ACTIVITY OF ANNACYCLUS PYRETHRUM IN ALBINO MICE
Abstract
ABSTRACT
Objective: A study which involves in detecting anticonvulsant activity from Anacyclus pyrethrum roots by using maximal electroshock seizure (MES)
in a dose-dependent way with the production of ethanolic extraction.
Methods: The MES test is considered to be a predictor of likely therapeutic efficacy against generalized tonic-clonic seizures.
Results: MES-induced tonic seizures can be prevented either by drugs that inhibit voltage dependent Na+ channels, such as phenytoin, valproate, and
lamotrigine or by drugs that block glutamatergic excitation mediated by the N-methyl-D-aspartate receptor like felbamate.
Conclusion: The efficiency of A. pyrethrum will be detected after the incubation time of the animal, and the values of the ethanolic extraction will be
tested for the anticonvulsant activity.
Keywords: Anacyclus pyrethrum, Albino mice, Maximal electroshock seizure, Anticonvulsant activity, Drugs.
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