GASTROPROTECTIVE EFFECT OF ABRUS PRECATORIUS ON ETHANOL-INDUCED AND ASPIRIN + PYLORUS LIGATION-INDUCED PEPTIC ULCER IN RATS

Abstract

Objective: The present work deals with investigation of Gastroprotective effect of Abrus precatorius on ethanol-induced and aspirin + pylorus ligation-induced peptic ulcer in rats. Methods: In ethanol-induced ulcer, after the pretreatment period of one hour, peptic ulcer was induced with absolute ethanol at a dose of 1 ml/200g (p.o.). Whereas, in aspirin + pylorus ligation-induced peptic ulcer, after the pretreatment with aspirin dose of 200mg/kg for 2 days then ulcer also induced by tight ligation of pylorus portion of stomach.

Results: In ethanol-induced and aspirin + pylorus ligation-induced peptic ulcer in rats models, Abrus precatorius (AP) has shown significant decrease in ulcer area and significant increase in the mucosal production and also decreased the level of lipid peroxidase (LPO), and increased the levels of superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT).

Conclusion: The present findings elucidate the therapeutic value of ethanolic extract of leaves of AP in the prevention of experimental peptic ulcer by virtue of its antioxidant, antisecretary and cytoprotective mechanisms.

Key words:  Abrus precatorius, ethanol induced ulcer, aspirin + pylorus ligation, antioxidant.