ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE POTENTIAL OF BALANITES ROXBURGHII FRUITS
Abstract
ABSTRACT
Objectives: The objective of the present study was to evaluate antioxidant activity and hepatoprotective potential of a hydroalcoholic extract of
Balanites roxburghii (BR) fruits.
Methods: Extraction was performed by triple maceration using ethanol:water as a solvent. The extracts were vaporated using rotavapor. Then
antioxidant capacities were tested using superoxide, hydroxyl, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Determination of hepatoprotective
model was performed by thiocetamide induced liver models.
Results: The hydroalcoholic extract of BR fruits produced a dose-dependent percentage inhibition on tested free radicals, i.e., superoxide anion
(50% inhibition concentrations [IC50] value 190.50 μg/ml), hydroxyl radical (IC50 value 266.30 μg/ml), and DPPH radical (IC50 value 175 μg/ml). After
treatment with silymarin and hydroalcoholic extract of BR in respective groups, they had showed good protection against thioacetamide induced liver
toxicity.
Conclusion: The results of the present investigation clearly indicate the free radical scavenging activity and hepatoprotective potential of a
hydroalcoholic extract of BR fruits and this activity is comparable with that of the standard drugs ascorbic acid and silymarin.
Keywords: Balanites roxburghii, Antioxidant activity, Hepatoprotective activity, Ascorbic acid.
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