ANTICONVULSANT PROPERTY OF SYNTHESIZED COMPOUND DHPM-5 IN LABORATORY ANIMALS
Abstract
Objective: The present study was undertaken to investigate the anti-convulsant effects of dihydropyrimidinone-5 (DHPM-5) in animal models.
Materials and Methods: Swiss albino mice were used for the study. The test drug and standard drugs were administered once daily for a period of
14 days. Maximal electroshock (MES) induced convulsion and strychnine induced convulsion models were used for the study. Phenytoin (PHT) and
Diazepam were used as standard agents throughout the study.
Results and Discussion: Anti-convulsant studies with test drug showed a significant protection in MES induced convulsion models in a dosedependent
manner.
There
was
a significant
(p<0.05)
decrease
in the duration
of
tonic
hind limb extension
at both
the
doses of
test
drug (200
mg/kg)
in
MES
model. Compared
with
the control
group,
treatment
with
test
drug
had no
significant effect
on onset and
duration
of convulsions
in
the
strychnine
induced
seizure
model. As expected,
the animals treated
with diazepam
4
mg/kg
increased
onset,
duration
of
convulsions
and latency
to
death
as compared
with control
group.
In all groups,
all animals
had
seizures
and all died.
DHPM-5
has
an influence on the excitatory
and
inhibitory
neurotransmission,
of special interest
being the increase
in the gamma
amino butyric acid levels.
Conclusion: The presence of the chemical constituents gave strength to its anti-convulsant action. However, further research is warranted to
determine the specific mode of its anti-convulsant activity.
Keywords: Dihydropyrimidinone-5, Strychnine, Seizure, Neurotoxicity.
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