ABROGATION OF CARBON TETRACHLORIDE (CCL4) INDUCED HEPATOTOXICTY BY AROGYAVARDHINI IN WISTAR RATS.

Abstract

From long back onwards Arogyavardhini, a herbo-mineral preparation  is used in the affections of liver & spleen disorders as a ayurvedic preparation.The present study was aimed to evaulate the  hepatoprotective effect of arogyavardhini in carbon tetrachloride (CCl₄) induced liver damage in wistar  rats. In the present study Arogyavardhini A (65 mg/kg, p.o) and Arogyavardhini B (65 mg/kg, p.o) were used to screen the hepatoprotective activity. Hepatotoxicity was induced by the CCl₄ ( 3 ml/kg, p.o), and silymarin (50 mg/kg, p.o) was taken as a standard. Biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate trasaminase (SGPT), alkaline phosphatase (ALP), total bilirubin and direct bilirubin levels were estimated. Histapathological examination of liver samples were also done. CCl₄ treated groups showed the elevated levels of biochemical parameters like SGOT, SGPT, ALP, total bilirubin, and direct bilirubin levels. In-case of Arogyavardhini treated groups significantly (p<0.01) prevented this hepatotoxicity. Histopathological examinations revealed the post-treatment of Arogyavardhini exhibited the protection of liver tissue from CCl₄ induced hepatotoxicity. The observed results strongly supports the hepatoprotective activity of arogyavardhini against CCl₄ induced hepatotoxicity.

 

Keywords: Arogyavardhini, CCl₄, Hepatotoxicity, SGOT, SGPT.