ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF SYZYGIUM ALTERNIFOLIUM BARK AGAINST HIGH-FAT DIET AND DEXAMETHASONE-INDUCED HYPERLIPIDEMIA IN RATS
Abstract
Objective: The present study is an attempt to investigate its anti-hyperlipidemic activity of methanolic extract of Syzygium alternifolium (MESA) using
high-fat diet (HFDs) and dexamethasone-induced hyperlipidemia.
Methods: MESA bark was evaluated for anti-hyperlipidemic activity in HFD and dexamethasone-induced hyperlipidemic rats. A comparison was also
made between the action of S. alternifolium bark extract and a known anti-hyperlipidemic drug atorvastatin (10 mg/kg body weight). The results of
the study were expressed as mean ± standard error, and data were analyzed using one-way analysis of variance test followed by Dunnett's t-test for
multiple comparisons. Values of p<0.05 were considered as significant.
Results: Oral administration of 100, 200 mg/kg body weight of the MESA bark exhibited a significant reduction (p<0.01) in serum lipid parameters
such as total cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL, and increase in high-density lipoprotein in hyperlipidemic rats of both
models as compared to hyperlipidemic control statistically. These extracts were found to possess better anti-hyperlipidemic potential.
Conclusion: Our results demonstrated that MESA bark possessed significant anti-hyperlipidemic activity and hence it could be a potential herbal
medicine as an adjuvant with existing therapy for the treatment of hyperlipidemia.
Keywords: Syzygium alternifolium, Hyperlipidemia, High-fat diet, Dexamethasone.
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