RECENT TRENDS IN MALE REPRODUCTIVE HEALTH PROBLEMS

Authors

  • Pallav Sengupta Department of Physiology, Vidyasagar College for Women, University of Calcutta

Abstract

This review critically evaluates the current trends of male reproductive health problems in relation to semen quality. Increasing trend in male reproductive disorders observed in recent years, are principally found to associate with lifestyle and environmental factors. Lifestyle-allied diseases could be controlled with modification in diet, living and working environment etc. This review outlines the changing trends in male reproductive health and highlights the alterations in semen quality, in scientific manner. Though scientific and public concern regarding the changes on male reproductive health has grown in past few decades but the demonstration of a geographical differences in sperm concentration, still appears to be controversial. The amplitude of the difference observed cannot only be explained by methodological or confounding factors, and must to some extent be attributed to ethnic, genetic or environmental factors. However, there are numerous reports indicating the chronologically declining sperm count and standard semen parameters in various population indicating the increasing trend of male reproductive health disorders.

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Author Biography

Pallav Sengupta, Department of Physiology, Vidyasagar College for Women, University of Calcutta

Department of Physiology, Vidyasagar College for Women, University of Calcutta

References

Colborn T, Dumanoski D, Myers JP. Our stolen future: Are We Threatening Our Fertility, Intelligence, and Survival? London: Penguin Group, 1996, pp. 316.

Guillette LJ, Gross TS, Masson GR, Matter JM, Percival HF, Woodward AR. Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Env Health Pers 1994;102:680-8.

Sumpter JP, Jobling S. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment. Env Health Pers 1995;103:173-8.

Irvine S. Is the human testis still an organ at risk? Brit Med J 1996;312:1557-8.

Ansell PE, Bennet V, Bull D, Jackson MB, Pike LA, Pike MC, et al. Cryptorchidism: a prospective study of 7500 consecutive male births, 1984–8. Arch Dis Childhood 1992;67:892-9.

HoffWanderas E, Tretli S, Fossa SD. Trends in incidence of testicular cancer in Norway, 1955–1992. Eur J Cancer, Part A: General Topics 1995;31:2044-8.

Setchell BP. Sperm counts in semen of farm animals, 1932–1995. Int J Androl 1997;20:209-14.

Bergstrom R, Adami HO, Mohner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Akre O, Hakulinen T. Increase in testicular cancer incidence in six European countries: a birth cohort phenomenon. J National Cancer Ins 1996;88:727-33.

Zheng T, Holford TR, Ma Z, Ward BA, Flannery J, Boyle P. Continuing increase in incidence of germ-cell testis cancer in young adults: experience from Connecticut, USA, 1935–1992. Int J Cancer 1996;65:723-9.

Hatton MQF, Paul J, Harding M, MacFarlane G, Robertson AG, Kaye SB. Changes in the incidence and mortality of testicular cancer in Scotland with particular reference to the outcome of older patients treated for non-seminomatous germ cell tumours. Eur J Cancer, Part A: General Topics 1995;31:1487-91.

Adami HO, Bergstrom R, Mohner M, Zatonski W, Storm H, Ekbom A, Tretli S, Teppo L, Ziegler H, Rahu M, Gurevicius R, Stengrevics A. Testicular cancer in nine northern European countries. Int J Cancer 1994:59:33-8.

Jensen TK, Giwercnam A, Carlsen E, Scheike T, Skakkebaek NE. Semen quality among members of organic food associations in Zealand, Denmark. Lancet 1996;347:1844.

Vierula M, Niemi M, Keiski A, Saaranen M, Saarikoski S, Suominen J. High and unchanged sperm counts of Finnish men. Int J Androl 1996;19:11-17.

Prener A, Engholm G, Jensen OM. Genital anomalies and risk for testicular cancer in Danish men. Epidemiology 1996;7:14-19.

Knight JA, Marrett LD. Parental occupational exposure and the risk of testicular cancer in Ontario. J Occup Env Med 1997;39:333-8.

Kristensen P, Andersen A, Irgens LM, Bye AS, Vagstad N. Testicular cancer and parental use of fertilizers in agriculture. Cancer Epidemiol Biomarkers Prevention 1996;5:3-9.

Møller H. Work in agriculture, childhood residence, nitrate exposure, and testicular cancer risk: a case-control study in Denmark. Cancer Epidemiol Biomarkers Prevention 1997;6:141-4.

Westergaard T, Olsen JH, Frisch M, Kroman N, Nielsen JW, Melbye M. Cancer risk in fathers and brothers of testicular cancer patients in Denmark. A population-based study. Int J Cancer1996; 66:627-31.

Davies TW, Palmer CR, Ruja E, Lipscombe JM. Adolescent milk, dairy product and fruit consumption and testicular cancer. Brit J Cancer 1996;74:657-60.

Editorial. An increasing incidence of cryptorchidism and hypospadias. The Lancet 1985;325:1311.

Berkowitz GS, Lapinski RH, Dolgin SE, Gazella JG, Bodian CA, Holzman IR. Prevalence and natural history of cryptorchidism. Pediatrics 1993;92:44-9.

Paulozzi LJ, Erickson JD, Jackson RJ. Hypospadia trends in two US surveillance systems. Pediatrics 1997;100:831-4.

Kallen B, Bertollini R, Castilla E, Czeizel A, Knudsen LB, Martinez-Frias ML, Mastroiacovo P, Mutchinick O. A joint international study on the epidemiology of hypospadias. Acta Paediat Scand 1986;324:1-52.

Berkowtiz GS, Lapinski RH, Godbold JH, Dolgin SE, Holzman IR. Maternal and neonatal risk factors for cryptorchidism. Epidemiology 1995;6:127-31.

Møller H, Skakkebaek NE. Risks of testicular cancer and cryptorchidism in relation to socio-economic status and related factors: case-control studies in Denmark. Int J Cancer 1996;66:287-93.

Nelson CM, Bunge RG. Semen analysis: evidence for changing parameters of male fertility potential. Fertil Steril 1974;25(6):503-7.

Hotchkiss R.S. Semen analysis of two hundred fertile men. Am J Med Sci 1938;196:362.

Farris EJ. The number of motile spermatozoa as an index of fertility in man: a study of 406 semen specimens. J Urol 1949;61:1099-104.

Falk HC, Kaufman SA. What constitutes a normal semen? Fertil Steril 1950;1:489-503.

MacLeod J, Gold RZ. The male factor in fertility and infertility. II. Spermatozoon counts in 1000 men of known fertility and in 1000 cases of infertile marriage. J Urol 1951;66:436-49.

Sengupta P. Environmental and occupational exposure of metals and their role in male reproductive functions. Drug Cheml Toxicol 2013;36:353-68.

MacLeod J, Wang Y. Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertility and Sterility, 1979;31:103-16.

Leto S, Frensilli FJ. Changing parameters of donor semen. Fertil Steril 1981;36:766-70.

James WH. Secular trend in reported sperm counts. Andrologia 1980;12:381-8.

Bostofte E, Serup J, Rebbe H. Has the fertility of Danish men declined through the years in terms of semen quality? A comparison of semen qualities between 1952 and 1972. Int J Fertility 1983;28:91-5.

Osser S, Liedholm P, Ranstam J. Depressed semen quality: a study over two decades. Arch Androl 1984;12:113-6.

Farrow S. Falling sperm quality: fact or fiction? Brit Med J 1994;309:1-2.

Bromwich P, Cohen J, Stewart I, Walker A. Decline in sperm counts: an artefact of changed reference range of ‘normal’? Brit Med J 1994;309:19-22

Olsen GW, Bodner KM, Ramlow JM, Ross CE, Lipshultz LI. Have sperm counts been reduced 50 percent in 50 years? A statistical model revisited. Fertil Steril 1995;63:887-93.

Chandra A, Sengupta P, Goswami H, Sarkar M. Effects of Dietary Magnesium on Testicular Histology, Steroidogenesis, Spermatogenesis and Oxidative Stress Markers in adult rats. Ind J Exp Biol 2013;51:37-47.

World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction, 1992.Cambridge: Cambridge University Press.

Keiding N, Giwercman A, Carlsen E, Skakkebaek NE. Commentary: importance of empirical evidence. Brit Med J 1994;309:22.

Keiding N, Skakkebaek NE. Sperm decline – real or artefact? Fertil Steril 1996;65:450-1.

Auger J, Kunstmann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. New England J Med 1995;332:281-5.

Sherins RJ. Are semen quality and male fertility changing? New England J Med 1995;332:327-8.

Van Waeleghem K, De Clercq N, Vermeulen L, Schoonjans F, Comhaire F. Deterioration of sperm quality in young healthy Belgian men. Hum Reprod 1996;11:325-9.

Bujan L, Mansat A, Pontonnier F, Mieusset R. Time series analysis of sperm concentration in fertile men in Toulouse, France, between 1977 and 1992. Brit Med J 1996;312:471-2.

Handelsman DJ. Sperm output of healthy men in Australia: magnitude of bias due to self-selected volunteers. Hum Reprod 1997;12:2701-5.

Fisch H, Goluboff ET, Olson JH , Feldshuh J, Broder S.J, Barad D H. Semen analyses in 1283 men from the United States over a 25-year period: no decline in quality. Fertil Steril 1996;65:1009-14.

Paulsen CA, Berman NG, Wang C. Data from men in greater Seattle area reveals no downward trend in semen quality: further evidence that deterioration of semen quality is not geographically uniform. Fertil Steril 1996;65:1015-20.

De Mouzon J, Thonneau P, Spira A, Multigner L. Semen quality has declined among men born in France since 1950. Brit Med J 1996;313:43.

Berling S, Wölner-Hanssen P. No evidence of deteriorating semen quality among men in infertile relationships during the last decade: a study of males from southern Sweden. Hum Reprod 1997;12:1002-5.

Swan SH, Elkin EP, Fenster L. Have sperm densities declined? A reanalysis of global trend data. Env Health Pers 1997;05:1228-32.

Fisch H, Goluboff ET. Geographic variations in sperm counts: a potential cause of bias in studies of semen quality. Fertil Steril 1996;65:1044-6.

Ginsburg J, Okolo S, Prelevic G, Hardiman P. Residence in the London area and sperm density (letter). Lancet 1994;343:230.

CECOS Féderation Française de, Auger J, Jouannet P. Evidence for regional differences of semen quality among fertile french men. Hum Reprod 1997;12:740-5.

Joffe M. Decreased fertility in Britain compared with Finland. Lancet 1996;347:1519-22.

Joffe M, Villard L, Li Z, Plowman R, Vessey M. A time to pregnancy questionnaire designed for long term recall: validity in Oxford, England. J Epidemiol Comm Health 1995;49:314-9.

Nieschlag E, Lammers U, Freischem C, Langer K, Wickings E. Reproductive functions in young fathers and grandfathers. J Clin Endocrinol Metab 1982;55:676–81.

Homonnai ZT, Fainman N, David MP, Paz GF. Semen quality and sex hormone pattern of 29 middle aged men. Andrologia 1982;14:164-70.

Dondero F, Mazzilli F, Giovenco P, Lenzi A, Cerasaro M. Fertility in elderly men. J Endocrinol Invest 1985;8(2):87-91.

Haidl G, Jung A, Schill WB. Aging and sperm function. Hum Reprod 1996;11:558-60.

Spandorfer SD, Avrech OM, Colombero LT, Palermo GD, Rosenwaks Z. Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection. Hum Reprod 1998;13:334-8.

Andolz P, Bielsa MA, Vila J. Evolution of semen quality in northeastern Spain: a study in 22,759 infertile men over a 36 year period. Hum Reprod 1999;14:731-5.

Rolf C, Kenkel S, Nieschlag E. Age-dependent changes in semen characteristics of patients attending a tertiary infertility clinic [abstract R-022]. In: Abstracts of the 15th Annual Meeting of the European Society of Human Reproduction and Embryology. Tours, France. Hum Reprod, 1999:288-9.

Eskenazi E, Bradman A, Gladstone E, Jaramillo S, Birch K, Holland N. CHAMACOS, a longitudinal birth cohort study: lessons from the fields. J Children’s Health. 2003;1:3-27.

Ng KK, Donat R, Chan L, Lalak A, Di Pierro I, Handelsman DJ. Sperm output of older men. Hum Reprod 200;19(8):1811-5.

Meeker JD, Godfrey-Bailey L, Hauser R. Relationships between serum hormone levels and semen quality among men from an infertility clinic. J Androl 2007;28(3):397-406.

Stewart TM, Liu DY, Garrett C, Jørgensen N, Brown EH, Baker HW. Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm output. Hum Reprod 2009;24(7):1561-8.

Tang WH, Jiang H, Ma LL, Hong K, Zhong Q, Yang CS, et al. [Relationship of sperm morphology with reproductive hormone levels in infertile men]. Zhonghua Nan Ke Xue 2012;18(3):243-7.

Jajoo S, Kalyani KR. Prevalence of abnormal semen analysis in patients of infertility at a rural setup in Central India. Int J Reprod Contracept Obstet Gynecol 2013;2(2):161-4.

Sengupta P. Health impacts of yoga and Pranayama: A state-of-the-art review. Int J Prev Med 2012;3:444-58.

Vine MF, Margolin BH, Morrison HI. Cigarette smoking and sperm density: a meta-analysis. Fertil Steril 1994;61:35-43.

Tiemessen CHJ, Evers JLH, Bots RSGM. Tight-fitting underwear and sperm quality. Lancet 1996;347:1844–5.

Sharpe RM, Skakkebaeck NE. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract. Lancet 1993;341:1392–5.

Danish Environmental Protection Agency. Male reproductive health and environmental chemicals with oestrogenic effects. Copenhagen: Ministry of Environment and Energy, 1995.

Orth JM, Gunsalus GL, Lamperti AA. Evidence from Sertoli celldepleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology 1988;122:787-94.

Orth JM. Proliferation of Sertoli cells in fetal and postnatal rats: a quantitative autoradiographic study. Anatom Rec 1982;203:485-92.

Marshall GR, Plant TM. Puberty occurring either spontaneously or induced precociously in rhesus monkey (Macaca mulatta) is associated with a marked proliferation of Sertoli cells. Biol Reprod 1996;54:1192-9.

Cortes D, Muller J, Skakkebaek NE. Proliferation of Sertoli cells during development of the human testis assessed by stereological methods. Int J Androl 1987;10:589-96.

Orth JM. The role of follicle-stimulating hormone in controlling Sertoli cell proliferation in testes of fetal rats. Endocrinology 1984;115:1248-55.

Sharpe RM. Declining sperm counts in men – is there an endocrine cause? J Endocrinol 1993;136:357-60.

Stillman RJ. In utero exposure to diethylstilbestrol: adverse effects on the reproductive tract and reproductive performance in male and female offspring. Am J Obs Gynecol 1982;142:905-21.

Wilcox AJ, Baird DD, Weinberg CR, Hornsby PP, Herbst AL. Fertility in men exposed prenatally to diethyl stilbestrol. New England JMed 1995;332:1411-6.

Hirobe S, He WW, Lee MM, Donahoe PK. Müllerian inhibiting substance messenger ribonucleic acid expression in granulosa and Sertoli cells coincides with their mitotic activity. Endocrinology 1992;131:854-62.

Skakkebaek NE, Berthelsen JG, Giwercman A, Muller J. Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 1987;10:19-28.

Ginsburg J. Tackling environmental endocrine disrupters. Lancet 1996;347:1501-2.

de Kretser DM. Declining sperm counts. Environmental chemicals may be to blame. Brit Med J 1996;312:457-8.

Jobling S, Sheahan D, Osborne JA, Matthiessen P, Sumpter JP. Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals. Env Toxicol Chemi 1996;15:194-202.

Walker AH, Bernstein L, Warren DW, Warner NE, Zheng X, Henderson BE. The effect of in utero ethinyl oestradiol exposure on the risk of cryptorchid testis and testicular teratoma in mice. Brit J Cancer 1990;62:599-602.

Sharpe RM, Fisher JS, Millar MM, Jobling S, Sumpter JP. Gestational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Env Health Pers 1995;103:2-9.

Handelsman DJ. Estimating familial and genetic contributions to variability in human testicular function: a pilot twin study. Int J Androl 1997;20: 215-21.

Published

01-04-2014

How to Cite

Sengupta, P. “RECENT TRENDS IN MALE REPRODUCTIVE HEALTH PROBLEMS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 7, no. 2, Apr. 2014, pp. 1-5, https://journals.innovareacademics.in/index.php/ajpcr/article/view/816.

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