STUDIES ON ANTIMICROBIAL AND ANTICANCER ACTIVITY OF SOLANUM TRILOBATIUM

Abstract

The present study is aimed to focus on antimicrobial  and anticancer activity plant extract Solanum trilobatum which was collected from Thirukovilur, Villupuram district. The cancer cell line HT- 29 obtained from King's Institute, Guindy Chennai. The plant extracts were prepared in  ethanolic extracts  to check the anti- microbial and anti-cancer  activity against bacterial pathogens (E. coli, Staphylococcus aureus, Pseudomonas, Klebsilla, Bacillus) and fungal pathogens (A. niger, A. flavus, Fusarium) by agar well diffusion method. The leaf of S. trilobatum were used for antimicrobial analysis, out of the best activity was observed E. coli with maximum zone of inhibition. On the other hand maximum antifungal activity was recorded with Aspergillus niger. The phytochemical analysis of S. trilobatum were performed such as alkaloids, flavonoids, sugars, glycosides, spannins, tannins, proteins, aminoacids and terpenoid were analyzed. Among the phytochemical test alkaloids showed the highest activity compared to other tests. Anti-cancer activity showed the least MIC value at concentration ranging from 2.7µg/ml to 60 µg/ml. A lowest MIC value (2.4 OD at conc. of 60 µg/ml). The results clearly evident that the  S. trilobatum extract are very useful improving survival and quality of life in patient suffering from advanced cancer.

Key words: Anticancer; Antifungal; Phytochemical; S. trilobatum; Antifungal