PENICILLAMINE IN INTERSTITIAL LUNG DISEASE: A TIMELY REMAINDER OF AN OLD FOE

Authors

  • Pawadshettar S
  • ACHARYA VK Professor & HOD, Department of pulmonary medicine, KMC, MangaloreManipal university
  • Arun M
  • Unnikrishnan B
  • Tantry Bv

Abstract

ABSTRACT
Penicillamine-induced lung injury has been sparsely reported in the literature. We report one such case with its wide-ranging ramifications. We
present an unusual case of drug induced-interstitial lung disease (DI-ILD) caused by penicillamine, resulting in acute lung injury in a young patient
with Wilson's liver disease. Patient had a interstial lung disease which was attributed to the drug pencillamine. Penicillamine-induced lung injury
has been sparsely reported in the literature and dose-dependent toxicity in a patient with neuro-psychiatric diseases adds to the rarity of the case.
Furthermore, the complexities involved in diagnosing DI-ILD are deliberated.
Keywords: Interstitial lung disease, Wilson's disease, Penicillamine.

Downloads

Download data is not yet available.

References

REFERENCES

Rosenow EC. The spectrum of drug-induced pulmonary disease. Ann

Intern Med 1972;77(6):977-91.

Fraser RS, Müller NL, Colman N, Pare PD. Pulmonary disease caused

by toxins, drugs, and irradiation. Diagnosis of Diseases of the Chest.

ed. Philadelphia: W.B. Saunders; 1999. p. 2517-92.

Rosenow EC. Drug-induced pulmonary disease. Dis Mon

th

;40(5):253-10.

White JP, Ward MJ. Drug-induced adverse pulmonary reactions.

Adverse Drug React Acute Poisoning Rev 1985;4(4):183-211.

Walshe JM. Wilson’s disease; new oral therapy. Lancet

;267(6906):25-6.

Camp, A. Penicillamine in the treatment of rheumatoid arthritis. Proc R

Soc Med 1977;70(2):67-9.

Foucher P, Biour M, Blayac JP, Godard P, Sgro C, Kuhn M, et al.

Drugs which may injure the respiratory system. Eur Respir J

;10(2):265-79.

Ellis SJ, Cleverley JR, Müller NL. Drug-induced lung disease: Highresolution

CT

findings. Am

J Roentgenol 2000;175(4):1019-24.

Aronin PA, Mahaley MS, Rudnick SA, Dudka L, Donohue JF,

Selker RG, et al. Prediction of BCNU pulmonary toxicity in patients

with malignant gliomas: An assessment of risk factors. N Engl J Med

;303(4):183-8.

Sitbon O, Bidel N, Dussopt C, Azarian R, Braud ML, Lebargy F, et al.

Minocycline pneumonitis and eosinophilia: A report on 8 patients. Arch

Intern Med 1994;154(14):1633-40.

Bone RC, Wolfe J, Sobonya RE, Kerby GR, Stechschulte D, Ruth WE,

et al. Desquamative interstitial pneumonia following long-term

nitrofurantoin therapy. Am J Med 1976;60(5):697-01.

Scott DL, Bradby GV, Aitman TJ, Zaphiropoulos GC, Hawkins CF.

Relationship of gold and penicillamine therapy to diffuse interstitial

lung disease. Ann Rheum Dis 1981;40(2):136-41.

Kubo K, Azuma A, Kanazawa M, Kameda H, Kusumoto M, Genma A,

Saijo Y, et al. Consensus statement for the diagnosis and treatment of

drug-induced lung injuries. Respir Investig 2013;51(4):260.

Published

01-01-2016

How to Cite

S, P., A. . VK, A. M, U. B, and T. Bv. “PENICILLAMINE IN INTERSTITIAL LUNG DISEASE: A TIMELY REMAINDER OF AN OLD FOE”. Asian Journal of Pharmaceutical and Clinical Research, vol. 9, no. 1, Jan. 2016, pp. 1-3, https://journals.innovareacademics.in/index.php/ajpcr/article/view/9383.

Issue

Section

Case Study(s)

Most read articles by the same author(s)