CASE REPOCASE REPORT ON METHOTREXATE-INDUCED ANGIOEDEMA, PANCYTOPENIA, AND STEVENS-JOHNSON SYNDROMERT ON METHOTREXATE INDUCED ANGIOEDEMA, PANCYTOPENIA AND STEVENS - JOHNSON SYNDROME

Abstract

ABSTRACT
A 52-year-old female patient was presented with the complaints of swelling of lips, difficulty in breathing, difficulty in swallowing of food, itching,
and facial puffiness and also showed the history of a skin lesion in the neck, forearm, and genitalia. Medical history of the patient showed that she
had been prescribed with methotrexate for rheumatoid arthritis. Within 10 days of treatment, the patient developed above mentioned signs and
symptoms. Further upon patient's systemic and physical examinations were done and then a diagnosis of pancytopenia, angioedema, and StevensJohnson
syndrome
were
made. According
to
Naranjo
adverse
drug
reaction
causality assessment
scale,
the association of
angioedema,
pancytopenia,

and
Stevens-Johnson
syndrome
due to
methotrexate
was
probable.
Methotrexate
was
withdrawn
from
the patient,
and the patient was
treated
with

methotrexate
antagonist Leucovorin
for
3
days
with a
frequency
of thrice daily
and injection Avil
(Pheniramine
maleate)
with a
frequency
of twice
daily
which
resolved
the complications of the patient.
Keywords: Methotrexate, Angioedema, Pancytopenia, Stevens-Johnson syndrome.