CORRELATION BETWEEN GLYCEMIC CONTROL AND LIPID PROFILE IN TYPE 2 DIABETIC PATIENTS: HbA1c AS AN INDIRECT INDICATOR OF DYSLIPIDEMIA

Abstract

Objectives: Dyslipidemia is one of the major risk factor for cardiovascular disease in Type 2 Diabetes mellitus, characterized by elevated Total cholesterol (TC), Triglycerides (TG), Low density lipoprotein (LDL) and decreased High density lipoprotein (HDL). Hemoglobin A1c (HbA1c) is widely used as an index of mean glycaemia, a measure of risk for the development of diabetes complications and a measure of the quality of diabetes care. The aim of this study was to determine the impact of glycemic control on lipid profile and to know utility of HbA1c as an indirect indicator of dyslipidemia.

Methods: A total of 490 Type 2 Diabetes mellitus patients (males 258, females 232) mean age 53.17 years standard deviation (S.D) 10.50 were included in this study.

Results: The age of type 2 diabetic patients were not significantly correlated with fasting blood glucose and HbA1c. The level of HbA1c was highly direct significant correlation with fasting blood glucose. The Age of Type 2 Diabetic patients were highly significant and inversely correlated with Total cholesterol, Triglycerides, Low-density Lipoprotein, where it was not significantly correlated with High-density Lipoprotein. The level of HbA1c was highly direct significant correlation with TC, TG, LDL, where it was not correlated with HDL.

Conclusion: The findings of this study clearly showed that HbA1c is not only a reliable glycemic index but also as an indirect indicator of dyslipidemia.

Keywords: Type 2 diabetes mellitus, HbA1c, Lipid profile, Dyslipidemia.