CARDIOVASCULAR RISK IN PATIENTS WITH MILD TO SEVERE SUBCLINICAL HYPOTHYROIDISM
Abstract
ABSTRACT
Objective: Cardiovascular risk as suggested by its name refers to altered lipid profile and C-reactive protein. It is associated with hypothyroidism
due to the effect of abnormal concentrations of thyroid hormones in the cardiovascular system and increased the risk of atherosclerosis. Subclinical
hypothyroidism is associated with cardiac abnormalities is not well-documented. C-reactive protein one of the markers of inflammation, considered to
be the predictor of cardiovascular diseases. It may be helpful in the assessment of future developments of cardiovascular abnormalities in subclinical
hypothyroidism.
Methods: Recently diagnosed 71 subclinical hypothyroidism patients were enrolled in the study and compared with 63 healthy individuals.
Patients were divided into two groups on the basis of thyroid stimulating hormone (TSH) concentration. Thyroid profile (TSH, free thyroxine,
triiodothyroinine) and C-reactive protein were estimated by enzyme-linked immunosorbent assay. Total cholesterol (TC), triglycerides (TG), and highdensity
lipoprotein-cholesterol
were
investigated
in the study
population by
a spectrophotometric
method,
and low-density
lipoprotein-cholesterol
(LDL-C)
was
measured
by
the Friedewald
formula.
Results and Conclusion: Altered lipid profile, as well as higher concentrations of C-reactive protein, was observed in subclinical hypothyroidism
patients as compared to controls. Higher concentration of TC, TG, and LDL was observed in subclinical hypothyroidism patients while the
concentration of high-density lipoprotein was lower in patients with subclinical hypothyroidism. The elevated concentration of C-reactive protein
was also observed in the patient group. Patients having TSH >10 µIU/ml have a higher risk of developing cardiovascular disease compared to patients
having TSH <10 µIU/ml and increasing concentration of C-reactive protein along with LDL-C may progress to cardiac abnormality.
Keywords: Subclinical hypothyroidism, C-reactive protein, Dyslipidemia, Cardiovascular risk.
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References
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