ETHOSOMES CARRYING ETODOLAC-EFFECTIVE DRUG CARRIER AS TOPICAL DOSAGE FORM IN THE TREATMENT OF RHEUMATOID ARTHRITIS
DOI:
https://doi.org/10.22159/ijap.2025v17i1.52153Keywords:
Etodolac, ethosomes, Carbopol 940, Topical, Rheumatoid ArthritisAbstract
Objective: The priority-based objective of this research was to, develop and evaluate the etodolac loaded Ethosomes as topical delivery in Rheumatoid Arthritis autoimmune disease.
Methods: The ethosomes (EE1-EE6) were prepared with varied concentrations (10%-60% v/v) of ethanol by using Rotary evaporator. The prepared Ethosomes evaluated for %EE (Entraptment Efficiency), Zeta potential, SEM (Scanning Electron Microscopy), TEM (Transmission Electron Microscopy), Vesicle size, In vitro release, In vivo study, Irritancy test, stability test etc.
Results: Prepared ethosomes analysed for zeta potential, vesicle size and % entrapment efficiency and ranges are found to be -18.50mV to -64.53mV, 166.66nm to 848.97nm and 53.15% to 89.35% respectively. Furthermore, when these ethosomes were incorporated in Carbopol 940 gels (EEC1-EEC6), it evaluated for appearance, spredability, pH, viscosity study, drug content and In-vitro drug release. All ethosomal gels show satisfactory results. After optimization of ethosomes (EE1-EE6) and ethosomal gels (EEC1-EEC6) on previous criteria, optimised formulations EE4 and EEC4 characterised for SEM, TEM, Ex-vivo permeation, Irritancy, In vivo and different analytical evaluation. The values of r2 were found higher for the first order model and Korsmeyer-Peppas model for all formulations. Irritancy test shows safe use of formulation and In vivo test shows that EEC4 had a significant inhibitory effect on edema which was developed in the right paw of rat by injecting carrageenan when it compared with plain Carbopol gel and marketed formulation.
Conclusion: The present study has confirmed that the formulated Etodolac Ethosomal gel can be used as best vehicle for the topical administration which may be used for the management of rheumatoid arthritis.
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