FORMULATION AND INVITRO EVALUATION OF VENLAFAXINE MATRIX TABLETS USINGGUM KONDAGOGU AS EXCIPIENT
DOI:
https://doi.org/10.22159/ijap.2025v17i1.52292Keywords:
Gum Kondagogu, Venlafaxine HCl, Sodium Alginate, Zinc Acetate, Matrix Tablets, Controlled releaseAbstract
Objective: A naturally obtained Gum Kondagogu (GK) investigated as a novel matrix-forming material for sustained drug delivery using Venlafaxine HCl (VH) as a model drug.
Methods: The VH tablets were prepared with different concentrations of GK along with other excipients such as sodium alginate and zinc acetate. The compressed tablets were then evaluated for pre-compression parameters, including flow properties, and post-compression parameters, such as hardness, friability, and drug content uniformity. Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies were conducted to assess potential interactions between the excipients and the drug. Additionally, the lead formulation underwent accelerated stability studies at 40 ± 2°C / 75 ± 5% RH for 3 months to evaluate the stability and consistency of drug release.
Results: The compressed tablets of VH with GK were found to have acceptable pre- and post-compression parameters. Among the various formulations tested, the one containing 0.25%w/v of GK, 0.3% of sodium alginate, and 0.3% of zinc acetate demonstrated a release profile closely matching that of a commercial tablet dosage form. FTIR and DSC studies confirmed that there were no interactions between the excipients and the drug. The lead formulation-maintained stability over 3 months of accelerated stability studies, with no significant changes in drug release observed during this period.
Conclusion: GK has shown potential as a controlled release agent for oral dosage forms, particularly for drugs like VH. The formulation containing 0.25%w/v of GK, 0.3% of sodium alginate, and 0.3% of zinc acetate exhibited a release profile similar to that of a commercial product and maintained stability under accelerated conditions. These findings suggest that GK could be a viable option for developing control release oral formulations.
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