WILAR, GOFARANA, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya Bandung-Sumedang KM 20,5 Desa Hegarmanah, Kecamatan Jatinangor, Sumedang, 45363 Indonesia, Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai-shi, 980-8579 Japan, Indonesia