NANOPARTICLE: AS TARGETED DRUG DELIVERY SYSTEM FOR DEPRESSION
Keywords:
Nanoparticles, Blood brain barrier, PolymerAbstract
Nanoparticles (NP) are defined as particles with a diameter smaller than 100 nm, are increasingly used in different applications, including drug carrier systems and to pass organ barriers such as the blood-brain barrier. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. Different methods containing various polymers are used for formulation of nanoparticle to increase therapeutic benefit, while minimizing side effect for drug delivery research. While benefits of nanotechnology are widely publicised, the discussion of the potential effects of their widespread use in the consumer and industrial products are just beginning to emerge. This review provides comprehensive analysis of data available on health effects of nanomaterials.
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Garud A, Singh D, Garud N. Solid lipid nanoparticles (SLN): method, characterization and applications. Int J Curr Pharm 2012;(1, Suppl 1):384-93.
Rajput N. Methods of preparation of nanoparticles–a review. Int J Adv Res Technol 2015;7:1806-11.
Abhilash M. Potential applications of nanoparticles. Int J Pharma Bio Sci 2010;1:1-12.
Pal SL, Jana U, Manna PK, Mohanta GP, Manavalan R. Nanoparticle: an overview of preparation and characterization. J Appl Pharm Sci 2011;1:228-34.
Hoet P, Irene Brüske-Hohlfeld, Oleg V Salata. Nanoparticles–known and unknown health risks. J Nanobiotechnol 2004;2:1-15.
Mehmood Y, Tariq A, Siddiqui FA. Brain targeting drug delivery system: a review. Int J Basic Appl Med Sci 2015;5:32-40.
Marijana Zovko, A Branka Zorc a. The novel ketoprofenamides: synthesis and spectroscopic characterization. Croatica Chem Acta Ccacaa 2003;76:335-41.
Peter Antich a, Frederick Bonte a, Aimei Wu b, NN Mallikarjuana b, Sanjeev Manohar b, Hsiang-Fa Liang c, et al. Targeted nanoparticles for drug delivery through the blood–brain barrier for Alzheimer’s disease. J Controlled Release 2005;108:193–214.
Ce Qi Yan Chen, Qing-Zhe Jing, Xing-Guo Wang. Preparation and characterization of catalase-loaded solid lipid nanoparticles protecting enzyme against proteolysis. Int J Mol Sci 2011;12:4282-93.
VJ Mohanraj, Y Chen. Nanoparticles–a review. Trop J Pharm Res 2006;5:561-73.
Hasan S. a review on nanoparticles: their synthesis and types. Res J Recent Sci 2015;4:1-3.
Nagavarma BVN, Hemant KS Yadav, Ayaz A, Vasudha LS, Shivakumar HG. Different techniques for preparation of polymeric nanoparticles-a review. Asian J Pharm Clin Res 2012;5(Suppl 3):16-23.
Paolo Blasi, Stefano Giovagnoli, Aurélie Schoubben, Maurizio Ricci, Carlo Rossi. Solid lipid nanoparticles for targeted brain drug delivery. Adv Drug Delivery Rev 2007;59:454–77.
Cristina Buzea, Ivan I, Pacheco Blandino, Kevin Robbie. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2007;2:MR17-MR172.
F Abhishek Garg, Sharad Visht, Pramod Kumar Sharma, Nitin Kumar. Formulation, characterization and application on nanoparticle: a review. Pelagia Research Library. Der Pharm Sin 2011;2:17-26.
Jean-Christophe Olivier. Drug transport to brain with targeted nanoparticles. J Am Soc Exp NeuroTher 2005;2:108–19.
Sailaja K, Amareshwar P, Chakravarty P. Different techniques used for the preparation of nanoparticles using natural polymers and their application. Int J Pharm Pharm Sci 2011;3(Suppl 2):4550.
Mahapatro A, Singh KD, Mahapatro Singh. Biodegradable nanoparticles are excellent vehicle for site directed in vivo delivery of drugs and vaccines. J Nanobiotechnol 2011;9:55.
Y ou Han Baea, Kinam Park. Targeted drug delivery to tumors: Myths, reality and possibility. J Controlled Release 2011; 153:198–205