IN VITRO ANTICANCER ACTIVITY OF 5' FLUO URACIL COATED CHITOSAN NANOPARTICLE
DOI:
https://doi.org/10.22159/ijcpr.2016v8i4.15267Keywords:
Nil, Chitosan nanoparticle, IC50 values, SEM, Anticancer activityAbstract
Objective: 5' Fluorouracil (5'FU) loaded chitosan nanoparticle (5FCN) was synthesized and tested for its anticancer activity against Hep G2, the liver cancer cell line.
Methods: The morphological characteristic of the 5FCN was visualized in Scanning Electron Microscope (SEM).
Results: The 5FCN revealed an IC50 value of 49.50 µl/ml. The study revealed that the 5FCN exhibited excellent anticancer activity against Hep G2 cell line which can be further studied for its application in cancer treatment.
Conclusion: Further studies would be focused onto report the drug release efficiency under different physiological conditions and evaluate them in animal model.
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