A VALIDATED SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VILAZODONE HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORM

Nita Yadav; Anju Goyal

doi:10.22159/ijcpr.2017v9i1.16637

Authors

Nita Yadav School of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, RJ.
Anju Goyal Department of Pharmaceutical Chemistry, B. N. PG College of Pharmacy, Udaipur

DOI:

https://doi.org/10.22159/ijcpr.2017v9i1.16637

Keywords:

Spectrophotometric Method, Vilazodone HCl, Validation

Abstract

Objective: In the present research work three simple, accurate, precise methods of the UV-visible spectrophotometric method was developed and validated for the estimation of Vilazodone HCl in bulk and tablet dosage.

Methods: Three methods were used for estimation of Vilazodone HCl using methanol. Method A involves zero order spectroscopy at absorption maximum of 241 nm; Method B involves first order derivative at 246.5 nm and Method C involves second-order derivative at 243.5 nm. The developed methods were validated according to ICH guidelines.

Results: The developed methods were found to be linear in the concentration range of 1-5 Âµg/ml. The mean percentage label claim of Vilazodone HCl was within the acceptable range. The accuracy data showed % recovery and % RSD within the range.

Conclusion: The developed methods were found to be accurate and precise. The % RSD values were within limits. These methods can be used for the routine analysis of Vilazodone HCl in bulk and tablet dosage form.

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