FORMULATION AND EVALUATION OF CHEWABLE MULTIVITAMIN TABLET
DOI:
https://doi.org/10.22159/ijcpr.2017v9i4.20958Keywords:
Multivitamin, Ascorbic acid, Riboflavin, Nicotinamide, Thiamine HCL, Direct compression, Chewable tabletAbstract
Objective: The overall objective of the present study was to formulate the chewable multivitamin tablet prepared by direct compression method.
Methods: The excipient used in this study are mannitol, sucrose, starch, talc, magnesium stearate, vanilla powder for the effective formulation. As it is multivitamin, ascorbic acid, riboflavin, nicotinamide, thiamine HCL are used and evaluated for precompression parameter. The chewable tablets were better presented using sweetener sucrose and vanilla powder as a flavouring agent. The formulated tablet was evaluated for post compression parameter. The chewable tablet are prepared to ensure that they are easily crushed by chewing. The tablet was evaluated for weight variation, hardness, thickness, friability, drug content. Their dissolution properties were assessed using USP (paddle apparatus).
Conclusion: From the above study, we conclude that the chewable tablets were prepared by direct compression method and gave the satisfactory and acceptable result. The tablet shows immediate drug release due to direct compressed tablet
Results: All the parameter were found within the specification. Drug content of ascorbic acid (103.62%-108.84%), riboflavin (99.88%-112.02%), nicotinamide (93.44%-100.31), thiamine Hcl (105.94%-108.5%) were found.
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