NANOPLEX: A REVIEW OF NANOTECHNOLOGY APPROACH FOR SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT
DOI:
https://doi.org/10.22159/ijcpr.2018v10i4.28467Keywords:
Nanotechnology, Nanoplex, Polyelectrolyte, Solubility enhancement, DissolutionAbstract
The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. Nanoplex means drug nanoparticle complex with the oppositely charged polyelectrolyte. In this technique, the cationic or anionic drug is reacted with an oppositely charged polyelectrolyte to form a complex. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. The nanoplex formed shows improved solubility and dissolution rate compared to raw drug crystals. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene-drug delivery, drug delivery to the brain and protein and peptide drug delivery.Downloads
References
Ochekpe NA, Olorunfemi PO, Ngwuluka NC. Nanotechnology and drug delivery. part 1: nanostructures for drug delivery. Trop J Pharm Res 2009a;8:265-74.
Manivannan R. Nanotechnology: a review. J Appl Pharm Sci 2011;1:8-16.
Bhattacharyya D, Singh S, Satnalika N, Khandelwal A, Jeon S. Nanotechnology, big things from a tiny world: a review. Int J U E-Ser Sci Technol 2009;2:29-38.
Malakar J, Ghosh A, Basu A, Nayak A. Nanotechnology: a promising carrier for intracellular drug delivery system. Int Res J Pharm 2012;3:36-40.
Lamba D. A brief review on nanotechnology. Impulse 2006;2:58-63.
Mohanraj VJ, Chen Y. Nanoparticles–a review. Trop J Pharm Res 2006;5:561-73.
Manmode AS, Sakarkar DM, Mahajan NM. Nanoparticles tremendous therapeutic potential: a review. Int J Pharm Tech Res 2009;1:1020-9.
Nagare SK, Ghughure SM, Salunke SB, Jadhav SG, Dhore RJ. A review on: nanosuspension an innovative acceptable approach in the novel delivery system. Uni J Pharm 2012;1:19-31.
Prabhakar CH, Balakrishna K. A review on nanosuspension in drug delivery. Int J Pharma Bio Sci 2011;2:549-58.
Verma A, Bindal MC. Nanosuspension: advantages and disadvantages. Ind J Nov Drug Delivery 2012;4:179-88.
Ekambaram P, Sathali A, Priyanka K. Solid lipid nanoparticle: a review. Sci Rev Chem Commun 2012;2:80-102.
Pragati S, Kuldeep S, Ashok S, Satheesh M. Solid lipid nanoparticle: a promising drug delivery technology. Int J Pharm Sci Nanotech 2009;2:509-16.
Kattamuri SB, Potti L, Vinukonda A, Bandi V, Changantipati S, Mogili RK. Nanofibers in pharmaceuticals-a review. Am J Pharmtech Res 2012;2:187-212.
Dineshkumar B, Krishnakumar K, Bhatt AR, John A, Paul D, Cherian J, et al. Nanofibers: potential applications in wound care management. Adv Poly Sci-Tech 2012;2:30-2.
Sambarkar PP, Patwekar SL, Dudhgaonkar BM. Polymer nanocomposites: an overview. Int J Pharm Pharma Sci 2012;4:60-5.
Hirlekar R, Yamagar M, Garse H, Mohit VIJ, Kadam V. Carbon nanotubes and its application: a review. Asian J Pharm Clin Res 2009;2:17-27.
Mishra R, Mishra A. Review on potential applications of carbon nanotubes and nanofibers. Int J Pharm Rev Res 2013;3:12-7.
Gurjar PN, Chouksey S, Patil G, Naik N, Agrawal S. Carbon nanotubes: pharmaceutical applications. Asian J Biomed Pharm Sci 2013;3:8-13.
Wanunu M. Nanopores: a journey towards dna sequencing. Phys Life Rev 2012;9:125-58.
Ochekpe NA, Olorunfemi PO, Ngwuluka NC. Nanotechnology and drug delivery. Part 2: Nanostructures for drug delivery. Trop J Pharm Res 2009b;8:275-87.
Jawahar N, Meyyanathan SN. Polymeric nanoparticles for drug delivery and targeting: a comprehensive review. Int J Health Allied Sci 2012;1:217-23.
Xu W, Ling P, Zhang T. Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. J Drug Delivery 2013;1-15. http://dx.doi.org/ 10.1155/2013/340315.
Mishra IN. Dendrimer: a novel drug delivery system. J Drug Delivery Ther 2011;1:70-4.
Shishu G, Maheshwari M. Dendrimers: the novel pharmaceutical drug carriers. Int J Pharm Sci Nanotech 2009;2:493-502.
Trivedi V, Bhimani B, Patel U, Daslaniya D, Patel G, Vyas B. Dendrimer: polymer of 211st century. Int J Pharm Res Biosci 2012;1:1-21.
Dineshkumar B, Krishnakumar K, John A, Paul D, Cherian J, Panayappan L. Nanocapsules: a novel nano-drug delivery system. Int J Res Drug Delivery 2013;3:14-6.
Cheow WS, Hadinoto K. Self-assembled amorphous drug-polyelectrolyte nanoparticle complex with enhanced dissolution rate and saturation solubility. J Colloid Interface Sci 2012;367:518-26.
Indira TK, Lakshmi PK. Magnetic nanoparticle–a review. Int J Pharm Sci Nanotechnol 2010;3:1035-42.
Patel RP, Joshi JR. An overview on nanoemulsion: a novel approach. Int J Pharm Sci Res 2012;3:4640-50.
Bera D, Qian L, Tseng T, Holloway PH. Quantum dots and their multimodal applications: a review. Materials 2010;3:2260-345.
Cheoww S, Hadinoto K. Self-assembled amorphous drug-polyelectrolyte nanoparticle complex with enhanced dissolution rate and saturation solubility. J Colloid Interface Sci 2012c;367:518-26.
Cheow WS, Hadinoto K. Green preparation of antibiotic nanoparticle complex as potential anti-biofilm therapeutics via self-assembly amphiphile-polyelectrolyte complexation with dextran sulfate. Colloids Surf B Biointerfaces 2012b;92:55-63.
Singhs K, Caram-Lelham N. Thermodynamics of kappa-carrageenan–amphiphilic drug interaction as influenced by specific counterions and temperature: a microcalorimetric and viscometric study. J Colloid Interface Sci 1998;203:430–46.
Hugerth A, Sandlot LO. The effect of polyelectrolyte counterion specificity, charge density, and confirmation on polyelectrolyte-amphiphile interaction: the carrageenan/furcellaran-amitriptyline system. Biopolymers 2001;58:186–94.
Cheow WS, Hadinoto K. Green amorphous nanoplex as a new supersaturating drug delivery system. Langmuir 2012a;28:6265-75.
Bonoiu A, Mahajan SD, Ling Y, Ding H, Ken-Tye Yong, Nair B, et al. MMP-9 gene silencing by a quantum dot–sirna nanoplex delivery to maintain the integrity of the blood-brain barrier. Brain Res 2009;1282:142-55.
Thomas JJ, Rekha MR, Sharma CP. Dextran-protamine polycation: an efficient nonviral and haemocompatible gene delivery system. Colloids Surf B 2010b;81:195-205.
Hattori Y, Hagiwara A, Ding W, Maitani Y. Nacl improves sirna delivery mediated by nanoparticles of hydroxyethylated cationic cholesterol with amido-linker. Bioorg Med Chem Lett 2008;18:5228-32.
Woitiski C, Ribeiro A, Neufeld R. Bioencapsulation into nanoplex carrier for oral insulin delivery. In: International Workshop On Bioencapsulation. Vienna Au Annals 2007;15:720-44, 4-13.
Ranjan A, Pothayee N, Seleem M, Jain N, Sriranganathan N, Riffle JS, et al. Drug delivery using novel nanoplex against a salmonella mouse infection model. J Nanopart Res 2010;12:905–14.