ANTIULCER ACTIVITY OF CONTROLLED RELEASE FORMULATION CONTAINING AQUEOUS EXTRACT OF ACACIA CATECHU WILLD ON RODENT MODELS

Basant Khare; Naina Dubey; Akash Sharma

doi:10.22159/ijcpr.2018v10i5.29689

Authors

Basant Khare Sagar Institute of Pharmaceutical Sciences, Sagar (M. P)
Naina Dubey Sagar Institute of Pharmaceutical Sciences, Sagar (M. P)
Akash Sharma Sagar Institute of Pharmaceutical Sciences, Sagar (M. P)

DOI:

https://doi.org/10.22159/ijcpr.2018v10i5.29689

Keywords:

Cimetidine, Acacia catechu willd, Herbal drug, Microspheres, Control group

Abstract

Objective: To study the Antiulcer activity of aqueous extract of acacia catechu willd on rodent models by controlled release formulation.

Methods: Microspheres were prepared by solvent evapoaration method and were evaluated for various parameters like SEM, stability and in vitro relese. And acacia catechu willd loaded microspheres were evaluated for in vivo study involving Gastric ulceration in rats was induced by Ethanol/HCl. Ulcer genic effect (Ulcer Index), pH and Total acidity, Histopathological studies.

Results: Results indicated that Acacia catechu willd microspheres contains some active constituents like flavanoid which are responsible for its anti ulcer activity. Also it was observed aqueous extract loaded microspheres showed maximum activity was found (200 mg/kg) with standard Cimetidine (100 mg/kg) also, the results revealed that aqueous extract microspheres at 200 mg/kg had reduced ulcer incidence significantly, when compared to the control as evident by decrease in ulcer score in the model.

Conclusion: Based on the result it can be concluded that microspheres loaded with aqueous extracts of Acacia catechu willd produced promising antiulcer activity and were safe.

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