• HAZHA ABDULLAH MOHAMMED AMEEN Department of Medicine, College of Medicine, University of Sulaimani. Kurdistan Region, Iraq
  • MOHAMMED OMER MOHAMMED Department of Medicine, College of Medicine, University of Sulaimani. Kurdistan Region, Iraq
  • KHADIJA MUHAMED AHMED Department of Oral Pathology, College of Dentistry, University of Sulaimani, Kurdistan Region, Iraq
  • REBAZ HAMA-GAREB ALI Department of Pharmaceutics, College of Pharmacy, University of Sulaimani, Kurdistan Region, Iraq
  • KAMAL AHMED SAEED Department of Surgery, College of Medicine, University of Sulaimani, Kurdistan Region, Iraq
  • SAAD ABDULRAHMAN HUSSAIN Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq



Nigella sativa oil, Oral mucositis, Chemoradiation, Head and neck cancer, Pro-inflammatory cytokines


Objective: Oral mucositis (OM) is a common treatment-induced toxicity in patients undergoing radiation or chemoradiation for head and neck cancers (HNC). The study aims to evaluate the anti-inflammatory effect of Nigella sativa (NS) oil in radiation-or chemoradiation-induced OM in HNC patients.

Methods: From Forty HNC patients were randomized to two groups, each of 20 patients. The first group was treated with NS oil mouthwash five times daily, while the second group was treated with the Magic mouthwash and served as a control. All patients received radiotherapy (RT) (60-70 Gy) in 30-35 fractions over 6-7 w with or without chemotherapy. Patients were evaluated once per week to estimate the severity and duration of OM and the salivary levels of IL-6 and TNF-α.

Results: 70% of patients were men and the commonest tumor locations were larynx (47.5%) and pharynx (22.5%) classified as stages III or IV. NS oil significantly reduces RTOG grade and OM severity after 3-4 w of RT, attenuates the elevation in salivary IL-6 and TNF-α production after 3-5 w.

Conclusion: Nigella sativa oil mouthwash have a potential anti-inflammatory activity that may be beneficial in minimizing or preventing radiation-or chemoradiation-induced oral mucositis in patients with head and neck cancer.


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How to Cite

AMEEN, H. A. M., M. O. MOHAMMED, K. M. AHMED, R. H.-G. ALI, K. A. SAEED, and S. A. HUSSAIN. “ANTI-INFLAMMATORY EFFECT OF NIGELLA SATIVA OIL ON CHEMORADIATION-INDUCED ORAL MUCOSITIS IN PATIENTS WITH HEAD AND NECK CANCERS”. International Journal of Current Pharmaceutical Research, vol. 11, no. 5, Sept. 2019, pp. 58-64, doi:10.22159/ijcpr.2019v11i5.35704.



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