FABRICATION AND EVALUATION OF HERBAL TRANSDERMAL FLIM FROM HIBISCUS ROSA SINENSIS
Keywords:Hibiscus rosasinensis, Transdermal patch, Comparison
Objective: In this present study attempt was made to formulate transdermal patches contains phytoconstituents. The naturopathy does not involve any adverse effects.
Methods: Hibiscus rosasinensis aquous extracts was prepared. Transdermalpatches were prepared using drug with two different polymers. The prepared transdermal films were evaluated for their physiochemical characteristics such as physical appearance, weight uniformity, thickness, folding endurance; moisture content, surface pH, Tensile strength. The in-vitro diffusion study was carried out using rat membrane. These parameters indicates the successful release of drug from the fabricated patch.
Results: With the overall observation it was concluded that the.
Conclusion: Fabrication of transdermal patch is successfully worked and subjected to diffusion study. Diffusion studies are carried out by using a fresh rat membrane. Phosphate buffer (6.6) is used as a solvent. Samples are collected for 24 h and absorbance is measured by using UV spectrophotometer at 226 nm. It showed the successful release of drug from the fabricated patch.
2. Bodmeier R, Paeratakul O. Leaching of water-soluble plasticizers from polymeric films prepared from aqueous colloidal polymer dispersions. Drug Delivery Int J Pharm Sci 1992;18:1865-82.
3. Sayan Bhattacharjee, S Nagalakshmi, S Shanmuganathan. Formulation characterization and in vitro diffusion studies of herbal extract loaded mucoadhesive buccal patches. Indian J Pharm Sci Res 2014;5:4965-75.
4. Itelima JU, Nwokedi VC, Ogbonna AI, Nyam MA. Phytochemical screening and antimicrobial activity evaluation of aqueous and ethanolic extracts of the leaf of azadirachta indica juss (Neem) on some. Microorganisms 2016;3:56-60.
5. Mariana C Galean, Carlos HG Martins, Jaqueline Massuco, Taís M Bauab, Luis VS Sacramento. Phytochemical screening of Azadirachta Indica a juss for. Antimicrobial Activity 2017;11:117-22.
6. Satyabrata Bhanja, BrijMohan Singh, Rawat Muvvala, Sudhakar Bibhuti, Bhusan Panigrahi. Design, development and evaluation of transdermal patches of ramipril. Int J Pharm Sci Res 2014;3:350.
7. Wahid A, Sridhar BK, Shivakumar S. Preparation and evaluation of transdermal drug delivery system of etoricoxib using modified chitosan. Indian J Pharm Sci 2008;70:55-60.
8. Suneetha Cherukuri, Uma Rajeswari Batchu, Kiranmai Mandava, Vidhyullatha Cherukuri. Formulation and evaluation of transdermal drug delivery of topiramate. Int J Pharm Investigation 2017;7:1-8.
9. Mukherge B. Design development physicochemical and in–vitro evaluation of transdermal patches containing diclofenac diethyl ammonium salt. J Pharm Sci 2002;91:2076-89.
10. Das K, Dang R, Bhaskaran S, Roopashree TS. Recent advances in medicinal plants in diabetes treatment. Recent progress in medicinal plants. Phytopharmacol Ther 2008;19:150–91.
11. Heard CM, Johnson S, Moss G, Thomas CP. In vitro transdermal delivery of caffeine, theobromine, theophylline, and catechin from an extract of Guarana, Paulliniacupana. Int J Pharm 2006;317:26-31.
12. Rao BK, Kesavulu MM, Apparao Ch. Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats. J Ethanopharmacol 2001;78:67–71.
13. Bhalla HL, Bhate AS. Feasibility studies on transdermal films of ephedrine. Indian Drugs 1994;31:328–32.
14. Ahad HA, Chitta SK, Anil KB, Amarnath RB, Chandrashekar AV, Gangadhar. Permeation studies of diclofenac sodium from ficuscarica fruit mucilage matrices for transdermal delivery. Int J Pharm Tech Res 2010;2:1013–7.