HYDROTROPIC SOLUBILIZATION AND LINEARITY PROFILE OF PAZOPANIB
DOI:
https://doi.org/10.22159/ijcpr.2020v12i4.39082Keywords:
Pazopanib, Hydrotropic, Solubilization, Solubility Profile, Linearity profile, Quantitative DeterminationAbstract
Objective: A study on the hydrotropic solubility and linearity profile of Pazopanib was carried out by using Niacinamide as the solubilizing agent as Pazopanib is poorly soluble in water.
Methods: Pazopanib was freely soluble in water when 2.8M Niacinamide was used as a solubilizing agent. Pazopanib shows an absorption maximum at 282 nm in First derivative mode of measurement using Shimazdu UV Spectrophotometer 1800 spectronic model.
Results: At the absorption maximum of 282 nm, Pazopanib shows a linear response in the range of 5μg/ml to 15μg/ml concentration.
Conclusion: The present study is useful for the aqueous solubilization and quantitative determination of Pazopanib in bulk drug and in pharmaceutical formulations thus avoiding toxic solvents.
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