• ISTIA ASRI PARINDA Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara
  • MUHAMMAD FIDEL GANIS SIREGAR Reproductive Endocrinology and Fertility Division, Department Obstetrics and Gynecology Faculty of Medicine, Universitas Sumatera Utara
  • HANUDSE HARTONO Reproductive Endocrinology and Fertility Division, Department Obstetrics and Gynecology Faculty of Medicine, Universitas Sumatera Utara
  • MAKMUR SITEPU Fetomaternal Division, Departmen od Obstetrics and Gynecology Faculty of Medicine, Universitas Sumatera Utara
  • INDRA G. MUNTHE Reproductive Endocrinology and Fertility Division, Department Obstetrics and Gynecology Faculty of Medicine, Universitas Sumatera Utara
  • DERI EDIANTO Oncology Gynecology Division, Departmen od Obstetrics and Gynecology Faculty of Medicine, Universitas Sumatera Utara
  • PUTRI C. EYANOER Department of Community and Preventive Medicine, Faculty of Medicine, Universitas Sumatera Utara



Menopause, Xerostomia, Estradiol


Objective: Menopause is a condition of permanent cessation of menstruation for 12 consecutive months. This occurs due to the loss of follicular ovarian activity so that estrogen levels decrease in the body. Menopause can occur at various ages, where the average age of menopause is 51-55 y. Menopause can affect oral tissues as well as other organ systems and cause xerostomia. Some of the symptoms of xerostomia include burning feelings, taste abnormalities, dysarthria, dysphagia, dysgeusia, and halitosis.

Methods: This study uses a case series design to assess the correlation between estradiol levels and the incidence of xerostomia in menopausal women. The incidence of xerostomia using the Xerostomia Inventory (XI) Score. This research was conducted in several places, namely H. Adam Malik General Hospital Medan and the hospital network of the Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sumatra Utara. The study population was all postmenopausal women at the H. Adam Malik General Hospital in Medan and the Obgyn FK USU network hospital that met the study inclusion-exclusion criteria. This research was conducted in February with a minimum sample of 38 people.

Results: In this study, 38 samples were obtained. Based on the results of the study, it was found that the most age groups were in the range of 56-60 y, the duration of menopause in the 5-10 y group, and the highest Body Mass Index (BMI) was obesity. The mean value of estradiol in menopausal women was 23.61±8.37 pg/ml; the mean value of XI score in menopausal women was 24.29±9.44. The correlation of estradiol levels and XI scores in menopausal women is a strong negative correlation that is-0.651 (p value<0.05). Correlation value of XI score and obesity in menopausal women is a low positive correlation with r = 0.342 (p value<0.05) while the value of correlation XI score with menopausal women who are not obese is a strong positive correlation with r = 0.793 (p value<0, 05).

Conclusion: Changes in the oral cavity are caused by aging and hypoestrogenism. The mean age of postmenopausal women was 56.98±4.35, with a mean BMI of 28.24±4.41. Estradiol levels in menopausal women are lower than women of reproductive age in each phase of the menstrual cycle. Significant reduction in estrogen production during menopause causes a decrease in salivary flow, leading to hyposalivation and symptoms of xerostomia.


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How to Cite

PARINDA, I. A., M. F. G. SIREGAR, H. HARTONO, M. SITEPU, I. G. MUNTHE, D. EDIANTO, and P. C. EYANOER. “CORRELATION BETWEEN ESTRADIOL SERUM LEVELS WITH XEROSTOMIA INVENTORY SCORE ON MENOPAUSAL WOMEN”. International Journal of Current Pharmaceutical Research, vol. 12, no. 4, July 2020, pp. 122-6, doi:10.22159/ijcpr.2020v12i4.39098.



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