FORMULATION OF AN ANTI-BACTERIAL CREAM FROM PLANTOXALIS CORNICULATA ANDITS EVALUATION
Keywords:Oxalis corniculata extract, Antibacterial cream, Anti-fungal
Objective: Even in areas where modern medicine is available, the interest on herbal medicines and their utilization have been increasing rapidly in recent years. Plant-derived substances and herbal medicines have recently attracted the great interest towards their versatile application as medical plants are the rich source of bioactive compounds used in traditional and modern medicine. The present work is to formulate and evaluate the antibacterial cream of oxalis corniculata extract.
Methods: The ethanolic extracts were prepared by using the maceration method.
Results: The agrochemical potential of methanolic extract, n-hexane, chloroform, ethyl acetate,and n-butanol soluble sfractions showed excellent activites against Escherichia coli, Shigella dysenteriae, Salmonella typhi, and Bacillus subtilis. Similarly the crude n-hexane and chloroform fractions were also found to have significant activity against fungal strains including Fusarium solani, Aspergillus flexneri, and Aspergillus flavus.
Conclusion: Oxalis corniculata is a common medicinal plant widely used against numerous infectious diseases. The two isolated compounds 5-hydroxy-6,7,8,4’-tetra methoxy flavone and 5,7,4’-trihydroxy-6,8-dimethoxyflavone were evaluated for antibacterial and antifungal activities. The results showed that latter compound was more active than that of the former.
2. Jain NK. Pharmaceutical product development. 1st Ed. CBS Publisher and Distributors. New Delhi; 2002. p. 221-8.
3. S Maji, P Dandapat, D Oja. In vitro antimicrobial potentialities of different solvent extracts of ethnomedicinal plants against clinically isolated human pathogens. J Phytol 2010;2:57–64.
4. RA Khan, MR Khan, S Sahreen, J Bokhari. Antimicrobial and phytotoxic screening of various fractions of Sonchus asper. Afr J Biotechnol 2010;9:3883–7.
5. Hosseini H, handali S, Parishani MP, Ghezelbash GHR, Ameri A. A comparative study of antibacterial effects of aqueous extract of oxalis corniculata L. With antibacterial effects of common antibiotics in S. aureus and E. coli infections. J Med Plants 2001;9:103-7.
6. Raghavendra MP, Staish S, Raveesha A. Phytochemical analysis and antibacterial activity of oxalis corniculata; a known medicinal plant. My Sci 2006;1:72-8.
7. Hsieh PC, Mau JL, Huang SH. Antimicrobial effect of various combinations of plant extracts. Food Microbiol 2001;18:35-43.
8. Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd ed. USA, Lea and Febiger; 1986. p. 526-33.
9. Handalimoghimipour E. Formulation and evaluation of antibacterial cream from oxalis corniculata aqueous extract. Jundishapur J Microbiol 2011;4:255-60.
10. Paul B. Encyclopedia of emulsion technology. 1st ed. USA, Marcel Decker Inc; 1993;1:131-405.
11. M Khan, RA Qureshi, SA Gillani, F Ullah. Antimicrobial activity of selected medicinal plants of Margalla hills, Islamabad, Pakistan. J Med Plant Res 2011;5:4665–70.
12. Moghimipour E, Ameri A, Saudatzadeh A, Salimi A, Siahpoosh A. Formulation of an anti-dermatophyte cream from eucalyptus camadulensis methanolic extract. Jundishapur J Natural Pharm Products 2009;4:32-40.