EFFECT OF POLYMERIC NANOPARTICLES OF CURCUMIN ON A549 CELL LINE
DOI:
https://doi.org/10.22159/ijcpr.2020v12i5.39765Keywords:
Curcumin, Scanning electron microscopy, Kinetic modelling, Cellular toxicityAbstract
Objective: Lung cancer cell line specially A549 is one of the most common malignant tumors. Curcumin is obtained from rhizomes of curcuma longa and does possess biological and pharmacological properties, among them anti-tumor activity is also one of the major findings. Here we try to developed a method for delivery of curcumin for cancer therapy.
Methods: Due to low water solubility and bioavailability curcumin delivery designed as polymeric nanoparticles and prepared by emulsification homogenization method.
Results: Characterization done by evaluating zeta size, potential, scanning electron microscopy. Release pattern also studied along with encapsulation and loading data. Nanoparticles were found to be spherical from morphological study and found to be below 200 nm. It does possess cytotoxic activity against lung cancer cell line and potent in comparison with its free from.
Conclusion: We can conclude that polymeric nanoparticles are suitable form to delivery for antitumor activity and have suitable anticancer ctivity.
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References
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2. Moreira AL, Eng J. Personalized therapy for lung cancer. Chest 2014;146:1649–57.
3. Syed HK, Liew KB, Loh GOK, Peh KK. Stability indicating HPLC–UV method for detection of curcumin in curcuma longa extract and emulsion formulation. Food Chem 2015;170:321–6.
4. Chen L, Bai B, Yang S, Yang R, Zhao G, Xu C, et al. Encapsulation of curcumin in recombinant human H-chain ferritin increases its water-solubility and stability. Food Res Int 2014;62:1147–53.
5. Dey S, Sreenivasan K. Conjugating curcumin to water soluble polymer stabilized gold nanoparticles via pH responsive succinate linker. J Mater Chem B 2015;3:824–33.
6. Dey S, Sreenivasan K. Conjugation of curcumin onto alginate enhances aqueous solubility and stability of curcumin. Carbohydr Polym 2014;99:499–507.
7. Pourreza N, Golmohammadi H. Application of curcumin nanoparticles in a lab-on-paper device as a simple and green pH probe. Talanta 2015;131:136–41.
8. Karewicz A, Bielska D, Loboda A, Malcher BG, Bednar J, Jozkowicz A, et al. Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives. Colloids Surf B 2013;109:307–16.
9. Ma M, Sun T, Xing P, Li Z, Li S, Su J, et al. A supramolecular curcumin vesicle and its application in controlling curcumin release. Colloids Surf A 2014;459:157–65.
10. Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007;595:105–25.
11. Darvesh AS, Carroll RT, Bishayee A, Novotny NA, Geldenhuys WJ, Van der Schyf CJ. Curcumin and neurodegenerative diseases: a perspective. Expet Opin Invest Drugs 2012;21:1123–40.
12. Lin JK. Molecular targets of curcumin. Adv Exp Med Biol 2007;595:227–43.
13. Sinha B, Mukherjee B, Pattnaik G. Poly-lactide-co-glycolide nanoparticlescontaining voriconazole for pulmonary delivery: in vitro and in vivo study. Nanomedicine 2013;9:94–104.
14. Satapathy SR, Siddharth S, Das D, Nayak A, Kundu CN. Enhancement of cytotoxicity and inhibition of angiogenesis in oral cancer stem cells by a hybrid nanoparticle of bioactive quinacrineand silver: implication of base excision repair cascade. Mol Pharm 2015;12:4011–25.
15. Prasad VK, Kavita NY, Chandrashekhar LB, Manohar JP. Standardization and quantification of curcumin from curcuma longa extract using UV visible spectroscopy and HPLC. J Pharmacogn Phytochem 2018;7:1913-8.
16. Shaw TK, Dipika M, Goutam D, Murari MP, Paramita P, Chakraborty S, et al. Successful delivery of docetaxel to rat brain using experimentally developed nanoliposome: a treatment strategy forbrain tumor. Drug Delivery 2017;24:346–57.
17. Garcia Diaz M, Foged C, Nielsen HM. Improved insulin loading inpoly(lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids. Int J Pharm 2015;30:84–91.
18. Satapathy SR, Siddharth S, Das D, Nayak A, Kundu CN. Enhancement of cytotoxicity and inhibition of angiogenesis in oralcancer stem cells by a hybrid nanoparticle of bioactive quinacrine and silver: implication of base excision repair cascade. Mol Pharm 2015;12:4011–25.
19. Nazanin H, Samantha G, Hongbin Han, Gang B. The effect of nanoparticle size on in vivo pharmacokinetics and cellular interaction. Nanomedicine 2016;11:247-58.
20. Danaei M, Dehghankhold M, Ataei S, Davarani FH, Javanmard R, Dokhani A. Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics 2018;10:1-17.
21. Asim H, Divanshu S, Suvadra D, Partha R, Arup M, Bhaskar S. Lactoferrin-modified betulinic acid-loaded PLGA nanoparticles are strong anti-leishmanials. Cytokine 2018;110:412-5.
22. Rajashekaraiah R, Kumar PR, Prakash N, Rao GS, Devi VR, Metta M, et al. Anticancer efficacy of 6-thioguanine loaded chitosan nanoparticles with or without curcumin. Int J Biol Macromol 2020;148:704-14.
Published
15-09-2020
How to Cite
SAIKIA, T., H. LALHLENMAWIA, LALDINCHHANA, P. K. ROY, and K. THANZAMI. “EFFECT OF POLYMERIC NANOPARTICLES OF CURCUMIN ON A549 CELL LINE”. International Journal of Current Pharmaceutical Research, vol. 12, no. 5, Sept. 2020, pp. 50-53, doi:10.22159/ijcpr.2020v12i5.39765.
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