FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILMS OF EBASTINE
DOI:
https://doi.org/10.22159/ijcpr.2020v12i5.39782Keywords:
Ebastine, Fast dissolving films, Hydroxypropyl methylcellulose, Crospovidone, In vitro dissolution studiesAbstract
Objective: To overcome the limitations of fast dissolving tablets, a novel fast dissolving film of ebastine was formulated for attaining quick onset of action, aiding in the enhancement of bioavailability favorable in severe conditions of allergies.
Methods: Films of ebastine were prepared by the solvent casting method using hydroxypropyl methylcellulose E-15, hydroxypropyl methylcellulose K-4 as a film base with different concentrations of crospovidone as superdisintegrant and polyethylene glycol-400 as a plasticizer. Further physical characteristics such as uniformity of weight, thickness, and drug content uniformity, tensile strength, folding endurance, percentage elongation, surface pH, disintegration and in vitro drug release were evaluated.
Results: The optimized formulations with film base hydroxypropyl methylcellulose E-15 and hydroxypropyl methylcellulose K-4 containing 8% crospovidone showed 99.34 % and 97.42 % of maximum cumulative percentage release respectively exhibiting first order kinetics. However, no significant change was observed in stability studies.
Conclusion: The concept of formulating fast dissolving films of ebastine offers a suitable approach in exhibiting rapid onset of action with improved delivery.
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References
2. Kaur M, Rana AC, Seth N. Fast dissolving films: an innovative drug delivery system. Int J Pharm Res Allie Sci 2013;2:14-24.
3. Gupta P, Bisht A, Rao NGR. Fast dissolving oral films: a comprehensive review. World J Pharm Res 2019;5:116–27.
4. Mishra R, Amin A. Formulation and characterization of rapidly dissolving films of cetirizine hydrochloride using pullulan as a film-forming agent. Ind J Pharm Edu Res 2011;45:71-7.
5. Ebast. Available from: http://www.unitedpharmacies.com/Ebast-ebastine.html [Last accessed on 05 Sep 2014
6. Ebastine Pharmacology. https://www.medicineindia.org/pharmacology-for-generic/1145/ebastine [Last accessed on 04 Sep 2014]
7. Saini P, Kumar A, Sharma P, Visht S. Fast disintegrating oral films: a recent trend of drug delivery. Int J Drug Dev Res 2012;4:80-94.
8. Nafee NA, Boraie MA, Ismail FA, Mortada LM. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. Acta Pharm 2003;53:199-212.
9. Reddy U, Reddy S, Katta M, Thyagaraju K. A detailed review of fast dissolving oral films. Indo Am J Pharm Res 2018;8:1351–26.
10. Cilurzo F, Minghetti P, Como A, Montanari L. Maltodextrin fast dissolving film: a feasibility study. Eur J Pharm Biopharm 2008;70:895-900.
11. Roshan B, Ravindranath S. Osteoarthritis: pathophysiology and current treatment modalities. J Drug Delivery Ther 2019;9:661–8.
12. Lakshmi PK, Malavika P, Vidya K. Formulation and evaluation of oral films of atomoxetine hydrochloride. Int Res J Pharm 2018;9:105–9.
13. Kumar GV, Krishna RV, William GJ, Konde A. Formulation and evaluation of buccal films of salbutamol sulphate. Ind J Pharm Sci 2005;67:160-4.
14. Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast dissolving film of salbutamol sulphate. Drug Dev Ind Pharm 2005;31:25-34.
15. Bagul Uddhav, Gujar Kishore, Patel Nancy, Sanjeevani Aphale, Shalaka Dhat. Formulation and evaluation of sublimed fast melt tablets of levocetirizine dihydrochloride. Int J Pharm Sci 2010;2:76-80.
16. Zankhana Patel, Rahil Bhura, Samir Shah. Formulation optimization and evaluation of mouth dissolving film of ramosetron hydrochloride. Int J Curr Pharm Sci 2020;12:99-105.
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