PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF HIGH LEVEL AMINOGLYCOSIDE RESISTANCE AMONG GRAM POSITIVE ORGANISMS IN A TERTIARY CARE CENTRE

Authors

  • DIVYA PRABHA A. Saveetha Medical College and Hospital, Thandalam, Chennai,
  • POOJA NAIR Department of Microbiology, Saveetha Medical College and Hospital
  • S. S. M. UMAMAGESWARI Department of Microbiology, Saveetha Medical College and Hospital
  • R. MONICA Department of Microbiology, Saveetha Medical College and Hospital
  • ROSY VENNILA Department of Microbiology, Saveetha Medical College and Hospital

DOI:

https://doi.org/10.22159/ijcpr.2021v13i1.40812

Keywords:

Aminoglycoside, Staphylococcus, Enterococcus, Streptococcus, Antimicrobial susceptibility

Abstract

Objective: The study is done to determine the prevalence and the antimicrobial susceptibility against the gram positive organisms with high level amino glycosides resistance.

Methods: This is a prospective study involving the analysis of clinical samples for gram positive organisms like Streptococcus species, Enterococcus species and Staphylococcus species and determining their antimicrobial susceptibility pattern.

Results: From the collected clinical samples, all the gram positive organisms show resistance to gentamicin. Most of the Staphylococcus species showed a wide resistance to erythromycin followed by ceftrioxazone and many Enterococcus species shows resistance to penicillin, erythromycin, ciprofloxacin.

Conclusion: The high level aminoglycoside resistant (HLAR) gram positive organisms showed susceptibility to few drugs that are prevalent in various clinical samples. Surveillance of antimicrobial resistance and sensitivity is essential in managing and control of infection.

Downloads

Download data is not yet available.

References

1. Mandell, Douglas, Bennett. Principal and practice of infectious disease (eighth edition. Vol 1); 2015. p. 235-51.
2. Vogelman BS, Craig WA. Postantibiotic effects. J Antimicrob Chemother 1985;15 Suppl A:37-46.
3. Davis BD. Mechanism of bactericidal action of aminoglycosides. Microbiol Rev 1987;51:341-50.
4. Indrelie JA, Wilson WR, Matsumoto JY, Geraci JE, Washington JA. 2nd. Synergy of imipenem or penicillin G and aminoglycosides against enterococci isolated from patients with infective endocarditis. Antimicrob Agents Chemother 1984;26:909-12.
5. Horodniceanu T, L Bougueleret, N El-solh, G Bieth, F Delbos. High level, plasmid-borne resistance to gentamicin in streptococcus faecalis subsp. Zymogenes Antimicrob Agents Chemother 1979;16:686-9.
6. Eliopoulos GM, Wennersten C, Zighelboim Daum S, Reiszner E, Goldmann D, Moellering RC Jr. High-level resistance to gentamicin in clinical isolates of streptococcus (Enterococcus) faecium. Antimicrob Agents Chemother 1988;32:1528-32.
7. Courvalin P, Davies J. Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin. Antimicrob Agents Chemother 1977;11:619-24.
8. Mederski Samoraj BD, BE Murray. High-level resistance to gentamicin in clinical isolates of enterococci. J Infect Dis 1983;147:751-7.
9. Habeeb Khadri, Mohammad Alzohairy. Prevalence and antibiotic susceptibility pattern of methicillin-resistant and coagulase-negative staphylococci in a tertiary care hospital in india. Int J Med Med Sci 2010;2:116-20.
10. Mohanty S, Jose S, Singhal R, Sood S, Dhawan B, Das BK, et al. Species prevalence and antimicrobial susceptibility of enterococci isolated in a tertiary care hospital of North India. Southeast Asian J Trop Med Public Health 2005;36:962-5.
11. Jain S, Kumar A, Kashyap B, Kaur IR. Clinico-epidemiological profile and high-level aminoglycoside resistance in enterococcal septicemia from a tertiary care hospital in east Delhi. Int J Appl Basic Med Res 2011;1:80-3.
12. Forbes BA, Sahm DF, Weissfeld AS. editors. Approaches to diagnosis of infectious diseases and evaluation of an antimicrobial activity. 12 ed. Washington DC: Mosby Elsevier. Diagnostic Microbiology; 2007. p. 78–215.

Published

15-01-2021

How to Cite

A., D. P., P. NAIR, S. S. M. UMAMAGESWARI, R. MONICA, and R. VENNILA. “PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF HIGH LEVEL AMINOGLYCOSIDE RESISTANCE AMONG GRAM POSITIVE ORGANISMS IN A TERTIARY CARE CENTRE”. International Journal of Current Pharmaceutical Research, vol. 13, no. 1, Jan. 2021, pp. 47-49, doi:10.22159/ijcpr.2021v13i1.40812.

Issue

Section

Original Article(s)

Most read articles by the same author(s)