• KANUPRIYA C. Department of Pharmaceutics, Rayat Institute of Pharmacy, Railmajra (Ropar), Punjab, India
  • NIMRATA SETH Department of Pharmaceutics, Rayat Institute of Pharmacy, Railmajra (Ropar), Punjab, India
  • N. S. GILL Department of Pharmaceutics, Rayat Institute of Pharmacy, Railmajra (Ropar), Punjab, India



Gastro retentive drug delivery, Upper gastrointestinal tract, Gastrointestinal, Local or systemic effect, Alkaline pH of the intestine, Retention time


Writing the review on gastro retentive drug delivery systems (GRDDS) was to start up the current literature with a special consequence on several gastro retentive approaches that have become main mode in the field of site-specific orally conduct sustained/controlled release drug delivery. Multi-furious ways have been made in research and development to rate-controlled oral drug delivery systems to solve physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). GRDDS is a tool to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Oral dosage forms as low bioavailability issues because of their swift gastric transition from the stomach, particularly in the case of drugs that are less soluble at an alkaline pH of the intestine. The drugs that produce their local action in the stomach get quickly emptied and don’t get enough residence time in the stomach. Many efforts have been made to extend the retention time of a drug delivery system to reduce the frequency of dose administration. GRDDS not only prolong dosing intervals but also increase patient compliance beyond the level of existing controlled release dosage forms. This article gives an overview of the advantages, disadvantages, and characterization of gastro retentive drug delivery systems. This also includes commercially available gastro retentive products and patents.


Download data is not yet available.


1. Sharma AR, Khan A. Gastro-retentive drug delivery system: an approach to enhance gastric retention for prolonged drug release. Indian J Pharm Sci 2014;5:1095.
2. Gupta P, Kesh M. Formulation, and evaluation of gastro-retentive floating tablets. Int J Pharm 2018;6:1.
3. Pandey A, Kumar G, Kothiya P, Brasilia Y. A review of current approaches in the gastro retentive drug delivery system. Asian J Pharm Health Sci 2012;2:139-46.
4. Sandhya P, Farhat A, Benaziya F, Durani HZ. A review of the gastro retentive drug delivery system of helicobacter pylori. Int J Pharma Res Rev 2013;1:403.
5. Rathod HJ, Mehta DP, Yadav JS. A review on gastroretentive drug delivery systems. Pharma Tutor 2016;4:29-40.
6. Badoni A, Ojha A, Gnanarajan G, Kothiyal P. Review on gastro retentive drug delivery system. Pharma Innov 2012;1(8, Part A):32.
7. Makwana A, Sameja K, Parekh H, Pandya Y. Advancements in controlled release gastroretentive drug delivery system: a review. Pharma Innov 2012;2:12-3.
8. Nayak KP, Upadhyay P, Valera AR, Chauhan NP. Gastroretentive drug delivery systems and recent approaches: a. J Pharm Res Opinion 2012;2:1-8.
9. Kagan L, Hoffman A. Selection of drug candidates for gastroretentive dosage forms: pharmacokinetics following continuous intragastric mode of administration in a rat model. Eur J Pharm Biopharm 2008;69:238-46.
10. Reddy LH, Murthy RS. Floating dosage systems in drug delivery. Crit Rev Ther Drug Carrier Syst 2002;19:553-85.
11. Hoffman A. Pharmacodynamic aspects of sustained-release preparations. Adv Drug Delivery Rev 1998;33:185-99.
12. Huang Y, Leobandung W, Foss A, Peppas NA. Molecular aspects of muco-and bioadhesion: tethered structures and site-specific surfaces.
J Controlled Release 2000;65:63-71.
13. Hooda A, Nanda A, Jain M Kumar, Rathee P. Optimization and evaluation of gastroretentive ranitidine HCl microspheres by using design expert software. Int J Biol Macromol 2012;51:691-700.
14. Pawar HA, Dhavale R. Development, and evaluation of gastroretentive floating tablets of an antidepressant drug by thermoplastic granulation technique. Beni-Suef University J Basic Appl Sci 2014;3:122-32.
15. Vyas SP, Khar RK. Gastro retentive system in controlled drug delivery: concepts and advances. Nayal AS, Pandey S, Gnanarajan G. Review: an overview on gastro retentive floating tablet. Int J Pharm Chem Sci 2013;2:1357-65.
16. Sravya K, Kavitha K, Rupeshr M, Jagdeesh Singh. Gastroretentive drug delivery systems: a review. Res J Pharm Biol Chem Sci 2012;3:966-80.
17. Machete H, Patel MR, Patel KR, Patel MS. An overview of floating drug delivery system. Pharma Tutor 2014;2:61-71.
18. Jamil F, Kumar S, Sharma S, Vishwakarma PS, Singh L. Review on stomach specific drug delivery systems: development and evaluation. Int J Res Pharm Biomed Sci 2011;2:142-71433.
19. Patel N, Nagesh C, Chandrashekhar S, Jinal P, Devdatt J. Floating drug delivery system: an acceptable innovative approach in gastroretentive drug delivery. Res J Pharm Dosage Forms Technol 2012;4:93-103.
20. Makwana A, Sameja K, Parekh H, Pandya Y. Advancements in controlled release gastroretentive drug delivery system: a review. J Drug Delivery Ther 2012;2:44-5.
21. Pilgaonkar PS, Rustomjee MT, Gandhi AS. Inventors; Rubicon Res Pvt Ltd, assignee. Gastroretentive dosage forms of GABA analogs. U. S patent application, US 13/700,794; 2013.
22. Chawla G, Bansal A. A means to address regional variability in intestinal drug absorption. Pharm Tech 2003;27:50-68.
23. Sheth PR, Tossounian J. The hydrodynamically balanced system (HBS™): a novel drug delivery system for oral use. Drug Dev Ind Pharm 1984;10:313.
24. Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery systems: a review. AAPS PharmSciTech 2005;6:372-90.
25. Prakash B, Neelima K, Snehith S, Ramesh C. Development of gastro retentive drug delivery system. ARS Pharmaceutica 2009;5:8-24.
26. Watts J, Smith A, Bond J, Lafferty W. Floating drug delivery composition. WO/2001/058424; 2001.
27. Vyas SP, Khar RK. Gastroretentive systems. In: Controlled drug Delivery. Vallabh Prakashan. Delhi, India; 2006. p. 197-217.
28. Clarke GM, Newton JM, Short MD. Gastrointestinal transit of pellets of differing size and density. Int J Pharm 1993;100:81-92.
29. Moes AJ. Gastric retention systems for oral drug delivery. Business Briefing: Pharmatech; 2003. p. 157-9.
30. Vedha Hari BN. The recent developments on gastric floating drug delivery systems: an overview. Int J Pharmtech Res 2010;2:524-34.
31. Rednick AB, Tucker SJ. Sustained-release bolus for animal husbandry, US patent US; 1970;3:507-952.
32. Geetha A, Kumar J Rajendra, Mohan CH Krishna. Review on: floating drug delivery systems. Int J Pharm Res Biomed Anal 2012;1:1-13.
33. Choi BY, Park HJ, Hwang SJ, Park JB. Preparation of alginate beads for floating drug delivery system effects of CO2 gas-forming agents. Int J Pharm 2002;239:81-91.
34. Ichikawam, Watenables, Miyake Y. A multiple-unit oral floating dosage systems preparation and in vivo evaluation of floating and sustained-release characteristics. J Pharm Sci 1991;80:1062-6.



How to Cite

C., K., N. SETH, and N. S. GILL. “GASTRO RETENTIVE DRUG DELIVERY SYSTEM: A SIGNIFICANT TOOL TO INCREASE THE GASTRIC RESIDENCE TIME OF DRUGS”. International Journal of Current Pharmaceutical Research, vol. 13, no. 1, Jan. 2021, pp. 7-11, doi:10.22159/ijcpr.2021v13i1.40818.



Review Article(s)