BUCCAL MUCOADHESIVE FILMS
DOI:
https://doi.org/10.22159/ijcpr.2021v13i4.42735Keywords:
Buccal films, Mechanism, Preparation methods and Evaluation, Recent advancement, Experimental designAbstract
The buccal route of administration has many advantages, including gastrointestinal bypass surgery and first pass through the liver. The mucoadhesive membrane is a retention dosage form that can release the drug directly into the biological matrix. Cheek technology has proven to be an advanced alternative to other traditional devices. The type of drug delivery system. This is a mature technology for systemic administration of active pharmaceutical ingredients [API]. In addition, due to their small size and thinness, these films improve patient compliance. Over the past decade, because it is a promising delivery alternative for multiple therapeutic categories, including peptides, vaccines and nanoparticles. Mucosal adhesions are currently explained by six theories: electronics, adsorption, wettability, diffusion, degradation and mechanics. Various in vitro and in vivo techniques are suggested. Study its mechanism. This study includes an overview of the mechanisms and theories of mucosal adhesion, and introduces the most commonly used methods. The "film casting method" involves casting an aqueous solution and/or organic solvent to produce a film suitable for the application route. The determination of key properties such as mucosal adhesion strength, uniformity of active ingredient content and permeability are important research areas in the field of buccal membrane design.
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References
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16. Senel S, Kremer M, Katalin N, Squier C. Delivery of bioactive peptides and proteins across oral (buccal) mucosa. Curr Pharm Biotechnol 2001;2:175-86.
17. Rajaram DM, Laxman SD. Buccal mucoadhesive films: a review. Syst Rev Pharm 2017;8:31.
18. Verma S, Kaul M, Rawat A, Saini S. An overview on buccal drug delivery system. Int J Pharm Sci Res 2011;2:1303.
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21. Wong C, Yuen K, Peh K. Formulation and evaluation of controlled release Eudragit buccal patches. Int J Pharm 1999;178:11-22.
22. Modi P, Mihic M, Lewin A. The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist™ system. Diabetes/Metab Res Rev 2002;18:S38-42.
23. Yang TZ, Wang XT, Yan XY, Zhang Q. Phospholipid deformable vesicles for buccal delivery of insulin. Chem Pharm Bull 2002;50:749-53.
24. Shojaei AH, Li X. In vitro permeation of acyclovir through porcine buccal mucosa. In: Proceedings of international symposium on controlled release of bioactive materials; 1996. p. 507-8.
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26. Patil SB, Murthy RS, Mahajan HS, Wagh RD, Gattani SG. Mucoadhesive polymers: means of improving drug delivery. Pharma Times 2006;38:25-8.
27. Salamat Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Delivery Rev 2005;57:1666-91.
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29. Mahboob MB, Riaz T, Jamshaid M, Bashir I, Zulfiqar S. Oral films: a comprehensive review. Int Curr Pharm J 2016;5:111-7.
30. Nagaraju T, Gowthami R, Rajashekar M, Sandeep S, Mallesham M, Sathish D, et al. Comprehensive review on oral disintegrating films. Curr Drug Delivery 2013;10:96-108.
31. Reddy PC, Chaitanya KS, Rao YM. A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. DARU J Pharm Sci 2011;19:385.
32. Ravindran CA. Pelagia research library. Der Pharm Sin 2011;2:218-40.
33. Mahboob MB, Riaz T, Jamshaid M, Bashir I, Zulfiqar S. Oral films: a comprehensive review. Int Curr Pharm J 2016;5:111-7.
34. Ramesha Chary RB, Vani G, Rao YM. In vitro and in vivo adhesion testing of mucoadhesive drug delivery systems. Drug Dev Industrial Pharm 1999;25:685-90.
35. Pankil AG, Patel MR, Patel KR, Patel NM. A review article on mucoadhesive buccal drug delivery system. Int J Pharm Res Dev 2011;3:121-9.
36. Vasantha PV, Puratchikody A, Mathew ST, Balaraman AK. Development and characterization of Eudragit based mucoadhesive buccal patches of salbutamol sulfate. Saudi Pharm J 2011;19:207-14.
37. Birudaraj R, Berner B, Shen S, Li X. Buccal permeation of buspirone: mechanistic studies on transport pathways. J Pharm Sci 2005;94:70-8.
38. Harris D, Robinson JR. Bioadhesive polymers in peptide drug delivery. Biomaterials 1990;11:652-8.
39. Gandhi SD, Pandya PR, Umbarkar R, Tambawala T, Shah MA. Mucoadhesive drug delivery systems-an unusual maneuver for site specific drug delivery system. Pharm Sci Monitan Int J Pharm Sci 2011;2:132-52.
40. Abruzzo A, Bigucci F, Cerchiara T, Cruciani F, Vitali B, Luppi B. Mucoadhesive chitosan/gelatin films for buccal delivery of propranolol hydrochloride. Carbohydrate Polymers 2012;87:581-8.
41. Patil BS, Tate SS, Kulkarni U, RC H WG. Development and in vitro evaluation of mucoadhesive buccal tablets of Tizanidine hydrochloride using natural polymer xanthan gum. Int J Pharm Sci 2011;8:140-6.
42. Elkayam R, Friedman M, Stabholz A, Soskolne AW, Sela MN, Golub L. Sustained release device containing minocycline for local treatment of periodontal disease. J Controlled Release 1988;7:231-6.
43. Avachat AM, Gujar KN, Wagh KV. Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate. Carbohydrate Polymers 2013;91:537-42.
44. Fernandes FP, Fortes AC, da Cruz Fonseca SG, Breitkreutz J, Ferraz HG. Manufacture and characterization of mucoadhesive buccal films based on pectin and gellan gum containing triamcinolone acetonide. Int J Polymer Sci 2018;1:2018.
45. Preis M, Woertz C, Schneider K, Kukawka J, Broscheit J, Roewer N, Breitkreutz J. Design and evaluation of bilayered buccal film preparations for local administration of lidocaine hydrochloride. Eur J Pharm Biopharm 2014;86:552-61.
46. Alopaeus JF, Hellfritzsch M, Gutowski T, Scherließ R, Almeida A, Sarmento B, et al. Mucoadhesive buccal films based on a graft co-polymer–a mucin-retentive hydrogel scaffold. Eur J Pharm Sci 2020;142:105142.
47. Chan SY, Goh CF, Lau JY, Tiew YC, Balakrishnan T. Rice starch thin films as a potential buccal delivery system: effect of plasticiser and drug loading on drug release profile. Int J Pharm 2019;562:203-11.
2. Verma P, Thakur AS, Deshmukh K, Jha AK, Verma S. Routes of drug administration. Int J Pharm Studies Res 2010;1:54-9.
3. Saxena A, Tewari G, Saraf SA. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon. Brazilian J Pharm Sci 2011;47:887-97.
4. Koyi PK, Khan AB. Buccal patches: a review. Int J Pharm Sci Res 2013;4:83.
5. Mahboob MB, Riaz T, Jamshaid M, Bashir I, Zulfiqar S. Oral films: a comprehensive review. Int Curr Pharm J 2016;5:111-7.
6. Ramteke KH, Dighe PA, Kharat AR, Patil SV. Buccal patches-a review. Int J Pharm 2014;4:297-308.
7. Madhavi BR, Murthy VS, Rani AP, Kumar GD. Buccal film drug delivery system-an innovative and emerging technology. J Mol Pharm Org Process Res 2013;1:2.
8. Mishra S, Kumar G, Kothiyal P. A review article: recent approaches in buccal patches. Pharma Innovation 2012;1:1.
9. Parmar HG, Jain JJ, Patel TK, Patel VM. Buccal patch: a technical note. Int J Pharm Sci Rev Res 2010;4:178-82.
10. Senel S, Ikinci GU, Kas S, Yousefi Rad A, Sargon MF, H?ncal AA. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery. Int J Pharm 2000;193:197-203.
11. Singh S, Jain S, Muthu MS, Tiwari S, Tilak R. Preparation and evaluation of buccal bioadhesive films containing clotrimazole. AAPS PharmSciTech 2008;9:660-7.
12. Danckwerts MP. Intraoral drug delivery. Am J Drug Delivery 2003;1:171-86.
13. Squier CA. The permeability of oral mucosa. Crit Rev Oral Biol Med 1991;2:13-32.
14. Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci 1998;1:15-30.
15. Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. J Pharm Pharm Sci 1998;1:15-30.
16. Senel S, Kremer M, Katalin N, Squier C. Delivery of bioactive peptides and proteins across oral (buccal) mucosa. Curr Pharm Biotechnol 2001;2:175-86.
17. Rajaram DM, Laxman SD. Buccal mucoadhesive films: a review. Syst Rev Pharm 2017;8:31.
18. Verma S, Kaul M, Rawat A, Saini S. An overview on buccal drug delivery system. Int J Pharm Sci Res 2011;2:1303.
19. Khairnar A, Jain P, Baviskar D, Jain D. Developmement of mucoadhesive buccal patch containing aceclofenac: in vitro evaluations. Int J PharmTech Res 2009;1:978-81.
20. Arakawa Y, Kawakami S, Yamashita F, Hashida M. Effect of low-molecular-weight ?-cyclodextrin polymer on release of drugs from mucoadhesive buccal film dosage forms. Biol Pharm Bull 2005;28:1679-83.
21. Wong C, Yuen K, Peh K. Formulation and evaluation of controlled release Eudragit buccal patches. Int J Pharm 1999;178:11-22.
22. Modi P, Mihic M, Lewin A. The evolving role of oral insulin in the treatment of diabetes using a novel RapidMist™ system. Diabetes/Metab Res Rev 2002;18:S38-42.
23. Yang TZ, Wang XT, Yan XY, Zhang Q. Phospholipid deformable vesicles for buccal delivery of insulin. Chem Pharm Bull 2002;50:749-53.
24. Shojaei AH, Li X. In vitro permeation of acyclovir through porcine buccal mucosa. In: Proceedings of international symposium on controlled release of bioactive materials; 1996. p. 507-8.
25. Manganaro AM, Wertz PW. The effects of permeabilizers on the in vitro penetration of propranolol through porcine buccal epithelium. Military Med 1996;161:669-72.
26. Patil SB, Murthy RS, Mahajan HS, Wagh RD, Gattani SG. Mucoadhesive polymers: means of improving drug delivery. Pharma Times 2006;38:25-8.
27. Salamat Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Delivery Rev 2005;57:1666-91.
28. Smart JD. Buccal drug delivery. Expert Opinion Drug Delivery 2005;2:507-17.
29. Mahboob MB, Riaz T, Jamshaid M, Bashir I, Zulfiqar S. Oral films: a comprehensive review. Int Curr Pharm J 2016;5:111-7.
30. Nagaraju T, Gowthami R, Rajashekar M, Sandeep S, Mallesham M, Sathish D, et al. Comprehensive review on oral disintegrating films. Curr Drug Delivery 2013;10:96-108.
31. Reddy PC, Chaitanya KS, Rao YM. A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. DARU J Pharm Sci 2011;19:385.
32. Ravindran CA. Pelagia research library. Der Pharm Sin 2011;2:218-40.
33. Mahboob MB, Riaz T, Jamshaid M, Bashir I, Zulfiqar S. Oral films: a comprehensive review. Int Curr Pharm J 2016;5:111-7.
34. Ramesha Chary RB, Vani G, Rao YM. In vitro and in vivo adhesion testing of mucoadhesive drug delivery systems. Drug Dev Industrial Pharm 1999;25:685-90.
35. Pankil AG, Patel MR, Patel KR, Patel NM. A review article on mucoadhesive buccal drug delivery system. Int J Pharm Res Dev 2011;3:121-9.
36. Vasantha PV, Puratchikody A, Mathew ST, Balaraman AK. Development and characterization of Eudragit based mucoadhesive buccal patches of salbutamol sulfate. Saudi Pharm J 2011;19:207-14.
37. Birudaraj R, Berner B, Shen S, Li X. Buccal permeation of buspirone: mechanistic studies on transport pathways. J Pharm Sci 2005;94:70-8.
38. Harris D, Robinson JR. Bioadhesive polymers in peptide drug delivery. Biomaterials 1990;11:652-8.
39. Gandhi SD, Pandya PR, Umbarkar R, Tambawala T, Shah MA. Mucoadhesive drug delivery systems-an unusual maneuver for site specific drug delivery system. Pharm Sci Monitan Int J Pharm Sci 2011;2:132-52.
40. Abruzzo A, Bigucci F, Cerchiara T, Cruciani F, Vitali B, Luppi B. Mucoadhesive chitosan/gelatin films for buccal delivery of propranolol hydrochloride. Carbohydrate Polymers 2012;87:581-8.
41. Patil BS, Tate SS, Kulkarni U, RC H WG. Development and in vitro evaluation of mucoadhesive buccal tablets of Tizanidine hydrochloride using natural polymer xanthan gum. Int J Pharm Sci 2011;8:140-6.
42. Elkayam R, Friedman M, Stabholz A, Soskolne AW, Sela MN, Golub L. Sustained release device containing minocycline for local treatment of periodontal disease. J Controlled Release 1988;7:231-6.
43. Avachat AM, Gujar KN, Wagh KV. Development and evaluation of tamarind seed xyloglucan-based mucoadhesive buccal films of rizatriptan benzoate. Carbohydrate Polymers 2013;91:537-42.
44. Fernandes FP, Fortes AC, da Cruz Fonseca SG, Breitkreutz J, Ferraz HG. Manufacture and characterization of mucoadhesive buccal films based on pectin and gellan gum containing triamcinolone acetonide. Int J Polymer Sci 2018;1:2018.
45. Preis M, Woertz C, Schneider K, Kukawka J, Broscheit J, Roewer N, Breitkreutz J. Design and evaluation of bilayered buccal film preparations for local administration of lidocaine hydrochloride. Eur J Pharm Biopharm 2014;86:552-61.
46. Alopaeus JF, Hellfritzsch M, Gutowski T, Scherließ R, Almeida A, Sarmento B, et al. Mucoadhesive buccal films based on a graft co-polymer–a mucin-retentive hydrogel scaffold. Eur J Pharm Sci 2020;142:105142.
47. Chan SY, Goh CF, Lau JY, Tiew YC, Balakrishnan T. Rice starch thin films as a potential buccal delivery system: effect of plasticiser and drug loading on drug release profile. Int J Pharm 2019;562:203-11.
