PHARMACEUTICAL WORLD OF PERMEATION ENHANCERS
DOI:
https://doi.org/10.22159/ijcpr.2021v13i5.1894Keywords:
Permeation enhancer, Essential oils, Drugs, Natural, SyntheticAbstract
The drugs with poor solubility results in delayed absorption which consequently affects the bioavailability. There are many drugs which are having good therapeutic value but not used commercially because of this reason. The permeation enhancers are therefore being utilized to counter this problem. There are many such synthetic and natural materials which have the ability to enhance the drug permeation rate. The essential oils, alcohols, terpenes, azoles and many other chemical derivatives have the capability to be used for permeation enhancer. The present review work suggested the role of permeation enhancer in the pharmaceutical world.
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Larregieu CA, Benet LZ. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Mol Pharm 2014;11:1335-44.
Charalabidis A, Sfouni M, Bergström C, Macheras P. The biopharmaceutics classification system (BCS) and the biopharmaceutics drug disposition classification system (BDDCS): beyond guidelines. Int J Pharm 2019;566:264-81.
Ozawa M, Tsume Y, Zur M, Dahan A, Amidon GL. Intestinal permeability study of minoxidil: assessment of minoxidil as a high permeability reference drug for biopharmaceutics classification. Mol Pharm 2015;12:204-11.
Tamura S, Ohike A, Ibuki R, Amidon GL, Yamashita S. Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats. J Pharm Sci 2002;91:719-29.
Li ZQ, Tian S, Gu H, Wu ZG, Nyagblordzro M, Feng G, et al. In vitro-in vivo predictive dissolution-permeation-absorption dynamics of highly permeable drug extended-release tablets via drug dissolution/absorption simulating system and pH alteration. AAPS PharmSciTech 2018;19:1882-93.
Tehler U, Fagerberg JH, Svensson R, Larhed M, Artursson P, Bergström CA. Optimizing solubility and permeability of a biopharmaceutics classification system (BCS) class 4 antibiotic drug using lipophilic fragments disturbing the crystal lattice. J Med Chem 2013;56:2690-4.
Caldeira TG, Saude Guimaraes DA, Dezani AB, Serra CHDR, de Souza J. In silico and in vitro prediction of gastrointestinal absorption from potential drug eremantholide C. J Pharm Pharmacol 2017;69:1468-76.
Tsume Y, Igawa N, Drelich AJ, Amidon GE, Amidon GL. The combination of GIS and biphasic to better predict in vivo dissolution of BCS class IIb drugs, ketoconazole and raloxifene. J Pharm Sci 2018;107:307-16.
Liu X, Chen T, Liu X, Chen Y, Wang L. Penetration effect of ostrich oil as a promising vehicle on transdermal delivery of sinomenine. J Oleo Sci 2013;62:657-64.
Wang Y, Zhou L, Ling J. Effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch. J Chinese Med Materials 2005;28:567-70.
Priborsky J, Takayama K, Nagai T, Waitzova D, Elis J. Combination effect of penetration enhancers and propylene glycol on in vitro transdermal absorption of insulin. Drug Design Delivery 1987;2:91-7.
Jampilek J, Brychtova K. Azone analogues: classification, design, and transdermal penetration principles. Med Res Rev 2012;32:907-47.
Qian L, Ma Z, Zhang W, Wang Q. Influence of penetration enhancers on in vitro transdermal permeation of L-tethrahydropalmatine. BMC Complementary Altern Med 2011;36:1729-32.
Cui LL, Ma YS, Han HX. Enhancing effect of volatile oils of rhizoma zingiberis, flos magnoliae and fructus litseae on permeation of rotundine in vitro. J Chinese Med Materials 2011;34:753-7.
Chen HL, Cai CC, Ma JY, Yu ML, Zhao MH, Guo JB, et al. Effect of the dispersion states of azone in hydroalcoholic gels on its transdermal permeation enhancement efficacy. J Pharm Sci 2018;107:1879-85.
Ramadon D, McCrudden MTC, Courtenay AJ, Donnelly RF. Enhancement strategies for transdermal drug delivery systems: current trends and applications. Drug Delivery Translational Res 2021;20:1–34.
Gunther A, Makuch E, Nowak A, Duchnik W, Kucharski L, Pelech R, et al. Enhancement of the antioxidant and skin permeation properties of betulin and its derivatives. Molecules 2021;26:3435.
Ossowicz P, Klebeko J, Janus E, Nowak A, Duchnik W, Kucharski L, et al. The effect of alcohols as cosmetic formulations on the percutaneous absorption and skin retention of ibuprofen modified with l-valine alkyl esters. RSC Adv 2020;10:41727–40.
Janus E, Ossowicz P, Klebeko J, Nowak A, Duchnik W, Kucharski L, et al. Enhancement of ibuprofen solubility and skin permeation by conjugation with L-valine alkyl esters. RSC Adv 2020;10:7570–84.
Bormann JL, Maibach HI. Effects of anatomical location on in vivo percutaneous penetration in man. Cutaneous Ocul Toxicol 2020;39:213-22.
Gupta R, Dwadasi B, Rai B. Samir mitragotri effect of chemical permeation enhancers on skin permeability: in silico screening using molecular dynamics simulations. Sci Rep 2019;9:1456.
Kala S, Juyal D. Recent developments on natural transdermal penetration enhancers. Int J Pharm Sci Res 2018;9:2190-6.
Yang Chen, Peng Quan, Xiaochang Liu, Manli Wang, Liang Fang. Novel chemical permeation enhancers for transdermal drug delivery. Asian J Pharm Sci 2014;9:51-64.
Barry BW. Dermatological formulation: percutaneous absorption. Marcel Dekker, New York; 1983.
Omar MM, Hasan OA, El Sisi AM. Preparation and optimization of lidocaine transferosomal gel containing permeation enhancers: a promising approach for enhancement of skin permeation. Int J Nanomed 2019;14:1551-62.
Loganathan V, Manimaran S, Jaswanth A, Sulaiman A, Shivaprasadha Reddy MV, Kumar BS, et al. The effects of polymers and permeation enhancers on releases of flurbiprofen from gel formulations. Indian J Pharm Sci 2001;63:200-4.
Rajan R, Vasudevan DT. Effect of permeation enhancers on the penetration mechanism of transfersomal gel of ketoconazole. J Adv Pharm Technol Res 2012;3:112-6.
Gupta A, Aggarwal G, Singla S, Arora R. Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Sci Pharm 2012;80:1061-80.
Tawfeek HM, Abdellatif AAH, Abdel-Aleem JA, Hassan YA, Fathalla D. Transfersomal gel nanocarriers for enhancement the permeation of lornoxicam. J Drug Delivery Sci Technol 2020;56A:101540.
Aggarwal G, Sanju D, Hari Kumar LS. Natural oils as skin permeation enhancers for transdermal delivery of olanzapine: in vitro and in vivo evaluation. Curr Drug Delivery 2012;9:172-81.
Patil UK, Saraogi R. Natural products as potential drug permeation enhancer in transdermal drug delivery system. Arch Dermatol Res 2014;306:419-26.
Sharma S, Aggarwal G, Dhawan S. Design and evaluation of Olanzapine transdermal patches containing vegetable oils as permeation enhancers. Der Pharm Lett 2010;2:84-98.
Nan L, Liu C, Li Q, Wan X, Guo J, Quan P, et al. Investigation of the enhancement effect of the natural transdermal permeation enhancers from Ledum palustre L. var. angustum N. Busch: mechanistic insight based on interaction among drug, enhancers and skin. Eur J Pharm Sci 2018;124:105-13.
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