• SARITHA M. Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhaptanam
  • SATYA PRAKASH PANDA Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhaptanam
  • SRAVANI BUDDHA Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhaptanam
  • P. V. KAMALA KUMARI Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhaptanam
  • Y. SRINIVASA RAO Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhaptanam



Proniosomes, Unilamellar, Multilamellar Vesicles, Hydrophobic, Hydrophilic


In the development of new dosage forms, drug delivery using nanotechnology is playing a vital role. Vesicular drug delivery systems have gained wide attention in the field of nanotechnology, such as niosomes, liposomes and proniosomes. Among the vesicular carriers, proniosomes are superior. Proniosomes are water-soluble carrier particles that are coated with surfactant so these are dry formulations. They are rehydrated to use on agitation in hot aqueous media within minutes to form niosomal dispersion immediately. Both hydrophilic and lipophilic drugscan be incorporated into these proteasomes. The physical stability problems of niosomes like aggregation, fusion and leaking are minimized in proniosomes, routes, such as oral, parenteral, dermal and transdermal, ocular, oral mucosal, vaginal, pulmonary, and intranasal. Proniosomes prolong the existence of the drug in the systemic circulation and finally reduces toxicity. This review focuses on different aspects of proniosomes such as preparation, characterization, in vitro drug release, entrapment efficiency, applications in the present scenario in the market and future trends.


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Rao R, Kakar R, Anju G, Sanju N. Review on proniosomes: an emerging vesicular system in drug delivery and cosmetics. Der Pharmacia Lettere. 2010;2(4):227-39.

Sadanandan A, Boby Johns G, Samuel J, Raj P, Thomas N, Daisy PA, Carla B. A review on: proniosomes-An innovative approach to vesicular drug delivery system. World J Pharm Pharm Sci. 2017;6(3):1039-53.

Kakr R, Rao R, Goswami A, Nanda S, Saroha K. A review on: proniosmes-An emerging vesicular system in drug delivery and cosmetics. Der Pharm Lett. 2010;2:227-39.

Puglia C, Trombetta D, Venuti V, Saija A, Bonina F. Evaluation of in vivo topical anti-inflammatory activity of indometacin from liposomal vesicles. J Pharm Pharmacol. 2004;56(10):1225-32. doi: 10.1211/0022357044445, PMID 15482636.

Akhilesh D, Hazel G, Kamath J. Proniosomes-A propitious provesicular drug carrier. Int J Pharm Pharm Sci Res. 2011;1(3):98-103.

Song S, Tian B, Chen F, Zhang W, Pan Y, Zhang Q, Yang X, Pan W. Potentials of proniosomes for improving the oral bioavailability of poorly water-soluble drugs. Drug Dev Ind Pharm. 2015;41(1):51-62. doi: 10.3109/03639045.2013.845841, PMID 24111828.

Sudhamani T, Priyadarisini N, Radhakrishnan M. A review on: proniosomes-A promising drug carrier. Int J Pharm Technol Res. 2010;2(2):1446-54.

Akhilesh D, Faishal G, Kamath J. Comparative study of carriers used in proniosomes. Int J Pharm Chem Sci. 2012;1(1):164-73.

Ijeoma F, Uchegbu SP, V Yas. Non-ionic surfactant-based vesicles (niosomes) in drug delivery. Int J Pharm. 1998;172(1-2):33-70.

Vyas SP, Khar RK. Review on: niosomes-targeted and controlled drug delivery novel carrier system, C.B.S [publication]. 1st ed; 2001;23:173-248.

Giddi HS, Arunagirinathan MA, Bellare JR. Self-assembled surfactant nano-structures important in drug delivery: a review. Indian J Exp Biol. 2007;45(2):133-59. PMID 17375554.

Walve JR, Rane BR, Gujrathi NA. A review on: proniosomes-A surrogate carrier for improved transdermal drug delivery system. Int J Res Ayurveda Pharm. 2011;2:743-50.

Comelles F, Sanchez-Leal J, Gonzalez JJ. Influence of ionic surfactants on the formation of liquid crystals in oleic acid/glycol/water systems. J Surfact Deterg. 2007;10(3):137-44. doi: 10.1007/s11743-007-1023-9.

Akhilesh D, Hazel G, Kamath JV. Review on: proniosomes-A propitious provesicular drug carrier. Int J Pharm Sci Res. 2011;1:98-103.

Jha AK, Kumar R, Kumar S, Jha SS. Vesicular system-carrier for drug delivery. Pharm Sin. 2011;2(4):192-202.

Triputianiludasi VP, Wankhade LM. Ingle, Sandeep Atram, Kiran K Tappar. A review on: proniosomes-A novel approach to vesicular drug delivery systems. 2012;3(1):1-6.

Kumari R, Verma K, Verma A, Yadav GK, Maurya SD. A review on proniosomes: a key to improved drug delivery. J Drug Deliv Ther. 2014;24:56-65.

Mishra A, Kapoor A, Bhargava S. A review on: proniosomal gel as a carrier for improved transdermal drug delivery. Asian J Pharm Life Sci. 2011;1:370-9.

Sankar V, Ruckmani K, Durga S, Jailani S. Proniosomes as drug carriers. Pak J Pharm Sci. 2010;23(1):103-7. PMID 20067875.

Kakkar R, Rao R, Kumar DN. A review on: formulation and characterization of valsartan proniosomes. Maejo Int J Sci Technol. 2011;5:146-58.

Keservani RK, Sharma AK, Ayaz MD. A review on novel drug delivery system for the vesicular delivery of drug by the niosomes. Int J Res Control Release. 2011;1:1-8.

Gupta R, kumar S, Gupta N, Kumar V, Prajapati SK, kumar A. A review on: the proniosomes development and optimization as a surrogated drug carrier for oral delivery of gliclazide. An Overview. 2014;3(9):275-80.

Pavala Rani N, Suryaprakashand TN, Senthamarai R. A review on: formulation and evaluation of rifampicin and gatifloxacinniosomes on logarithmic phase cultures of mycobacterium tuberculosis. Int J Pharmaciuetical Biol Sci. 2010;1:379-86.

Kapil S, Rao R, Saini V. A review on: preparation and evaluation of lornoxicamniosomal gel. Int Res J Pharm. 2012;3:378-83.

Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery- an overview. Acta Pharmaceutica Sinica B. 2011;1(4):208-19. doi: 10.1016/j.apsb.2011.09.002.

Alsarra IA, Hamed AY, Alanazi FK, El Maghraby GM. Vesicular systems for intranasal drug delivery. Neuromethods. 2010:175-203. doi: 10.1007/978-1-60761-529-3_8.

Solanki AB, Parikh JR, Parikh RH. Formulation and optimization of piroxicam proniosomes by 3-Factor, 3-level box-behnken design. AAPS PharmSciTech. 2007;8(4):E86. doi: 10.1208/pt0804086, PMID 18181547.

Verma P, Prajapati SK, Yadav R, Senyschyn D, Shea PR, Trevaskis NL. Single intravenous dose of novel flurbiprofen-loaded proniosome formulations provides prolonged systemic exposure and anti-inflammatory effect. Mol Pharm. 2016;13(11):3688-99. doi: 10.1021/acs.molpharmaceut.6b00504, PMID 27632682.

Fang JY, Yu SY, Wu PC, Huang YB, Tsai YH. In vitro skin permeation of estradiol from various proniosome formulations. Int J Pharm. 2001;215(1-2):91-9. doi: 10.1016/s0378-5173(00)00669-4, PMID 11250095.

Nimbalwar M, Upadhye K, Dixit Gouri. Fabrication and evaluation of ritonavir proniosomal transdermal gel as a vesicular drug delivery system. Pharmacophore. 2016;7(2):82-95.

Gurrapu A, Jukanti R, Bobbala SR, Kanuganti S, Jeevana JB. Improved oral delivery of valsartan from maltodextrin based proniosome powders. Adv Powder Technol. 2012;23(5):583-90. doi: 10.1016/j.apt.2011.06.005.

Abd-Elbary A, El-Laithy HM, Tadros MI. Sucrose stearate-based proniosome-derived niosomes for the nebulisable delivery of cromolyn sodium. Int J Pharm. 2008;357(1-2):189-98. doi: 10.1016/j.ijpharm.2008.01.056, PMID 18339494.

Shukr MH, Eltablawy NA. Development and optimization of novel controlled-release pioglitazone provesicular powders using 3² factorial design. Drug Deliv Transl Res. 2015;5(1):51-62. doi: 10.1007/s13346-014-0215-x, PMID 25787339.

M Abdou E, M Ahmed N. Terconazole proniosomal gels: effect of different formulation factors, physicochemical and microbiological evaluation. J Pharm Drug Deliv Res 2016;05(1). doi: 10.4172/2325-9604.1000144.

Abd El-Alim SH, Kassem AA, Basha M. Proniosomes as a novel drug carrier system for buccal delivery of benzocaine. J Drug Deliv Sci Technol. 2014;24(5):452-8. doi: 10.1016/S1773-2247(14)50087-1.

Sahoo RK, Biswas N, Guha A, Kuotsu K. Maltodextrin based proniosomes of nateglinide: bioavailability assessment. Int J Biol Macromol. 2014;69:430-4. doi: 10.1016/j.ijbiomac.2014.05.075, PMID 24909314.

Shaker DS, Nasr M, Mostafa M. Bioavailability and hypocholesterolemic effect of proniosomal simvastatin for transdermal delivery. Int J Pharm Pharm Sci. 2013;5:344-51.

Gupta A, Prajapati SK, Balamurugan M, Singh M, Bhatia D. Design and development of a proniosomal transdermal drug delivery system for captopril. Trop J Pharm Res. 2007;6(2):687-93. doi: 10.4314/tjpr.v6i2.14647.

Vora B, Khopade AJ, Jain NK. Proniosome based transdermal delivery of levonorgestrel for effective contraception. J Control Release. 1998;54(2):149-65. doi: 10.1016/s0168-3659(97)00100-4, PMID 9724902.

Akhilesh D, Bini KB, Kamath JV. Comparative study of carriers used in proniosomes. Int J Pharm Chem Sci. 2012;3:6-12.

Moser P, Marchand Arvier M, Labrude P, Handjanivila RM, Vignerson C. Niosomes d hemogolbine. I. Preparation, properties physicochimiques et oxyphoriques, Stabilite. Pharm Acta Helv. 1989;64(7):192-202.



How to Cite

M., S., . S. P. PANDA, S. BUDDHA, P. V. K. KUMARI, and Y. S. RAO. “PRONIOSOMES: A VESICULAR DRUG DELIVERY SYSTEM”. International Journal of Current Pharmaceutical Research, vol. 13, no. 6, Nov. 2021, pp. 32-36, doi:10.22159/ijcpr.2021v13i6.1925.



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