• ROHIT SHANKAR MANE Unimech Research and Testing Centre, Unimech Healthcare, Bangalore, 560058, India
  • ASAMA NADAF Department of Microbiology, Mahavir Mahavidyalaya, Kolhapur, 416006, India



Thermophiles, Ecology, Thermoenzymes, Thermostability, Applications


Enzymes from incredibly thermophilic microorganisms have been of innovative interest for quite a while in view of their capacity to catalyses responses of modern importance at raised temperatures. Most of the potential bioprospecting is at present identified with the investigation of the extremophiles and their likely use in modern cycles. As of late microbial enzymes discover applications in different businesses and comprise a significant gathering of modern enzymes. Present review article reveals basics of thermophilic bacteria and their applications with thermostability.


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Anand SS, Hawkes C, De Souza RJ, Mente A, Dehghan M, Nugent R, Zulyniak MA, Weis T, Bernstein AM, Krauss RM, Kromhout D, Jenkins DJA, Malik V, Martinez-Gonzalez MA, Mozaffarian D, Yusuf S, Willett WC, Popkin BM. Food consumption and its impact on cardiovascular disease: importance of solutions focused on the globalized food system: A report from the workshop convened by the World Heart Federation. J Am Coll Cardiol. 2015 Oct 6;66(14):1590-614. doi: 10.1016/j.jacc.2015.07.050, PMID 26429085.

Mane RS. Therapeutic applications of bioactive compounds obtained by endophytic Thielaviopsis basicola isolated from Ximenia americana, Western Ghats of India. J Microbiol Biotechnol Food Sci. 2020;9(5):870-8. doi: 10.15414/jmbfs.2020.9.5.870-878.

Acharya PB, Acharya DK, Modi HA. Optimization for cellulase production by Aspergillus niger using saw dust as substrate. Afr J Biotechnol. 2008;7(22):4147-52.

Zhang R, Naughton DP. Vitamin D in health and disease: current perspectives. Nutr J. 2010 Dec;9:65. doi: 10.1186/1475-2891-9-65, PMID 21143872.

Metchnikoff E. Lactic acid as inhibiting intestinal putrefaction. The prolongation of life: optimistic studies W. London: Heinemann; 1907. p. 161-83.

Tissier H. The treatment of intestinal infections by the method of transformation of the intestinal bacterial flora. C R Soc Biol. 1906;60:359-61.

Acharya S, Chaudhary A. Effect of nutritional and environmental factors on cellulases activity by thermophilic bacteria isolated from hot spring. J Sci Ind Res. 2011;70:142-8.

Ando S, Ishida H, Kosugi Y, Ishikawa K. Hyperthermostable endoglucanase from Pyrococcus horikoshii. Appl Environ Microbiol. 2002;68(1):430-3. doi: 10.1128/AEM.68.1.430-433.2002, PMID 11772658.

Mane RS. Fungal endophytes: sources and prospects. J Med Plants Stud. 2018;6(2):121-6.

Andrade CMMC, Nei P Jr, Antranikian G. Extremely thermophilic microorganisms and their polymer hydrolytic enzymes. Braz J Microbiol. 1999;30:287-98.

Aro N, Ilmen M, Saloheimo A, Penttila M. ACEI is a repressor of cellulase and xylanase genes of Trichoderma reesei. Appl Environ Microbiol. 2002;69:56-65.

Mane RS, Paarakh PM, Vedamurthy AB. Brief review on fungal endophytes. Int J Second Metabolites. 2018;5(4):288-303. doi: 10.21448/ijsm.482798.

Aro N, Saloheimo A, Ilmén M, Penttilä M. ACEII, a novel transcriptional activator involved in regulation of cellulase and xylanase genes of Trichoderma reesei. J Biol Chem. 2001; 276(26):24309-14. doi: 10.1074/jbc.M003624200, PMID 11304525.

Dienes D, Egyhazi A, Reczey K. Treatment of recycled fiber with trichoderma cellulases. Ind Crops Prod. 2004;20(1):11-21. doi: 10.1016/j.indcrop.2003.12.009.

Egorova K, Antranikian G. Industrial relevance of thermophilic Archaea. Curr Opin Microbiol. 2005;8(6):649-55. doi: 10.1016/j.mib.2005.10.015, PMID 16257257.

Fangdong Z. Study on the isolation of thermophilic cellulolytic bacteria by using 3 kinds of medium and the determination of its enzyme activity. J Anhui Agric Sci. 2008;36(15):6171-2.

Firn RD. Bioprospecting-why is it so unrewarding? Biodivers Conserv. 2003;12(2):207-16. doi: 10.1023/ A:1021928209813.

Fitter J. A measure of conformational entropy change during thermal protein unfolding using neutron spectroscopy. Biophys J. 2003;84(6):3924-30. doi: 10.1016/S0006-3495(03)75120-0, PMID 12770898.

Folan MA, Coughlan MP. The cellulase complex in the culture filtrate of the thermophyllic fungus, Talaromyces emersonii. Int J Biochem. 1978;9(10):717-22. doi: 10.1016/0020-711x(78)90038-1, PMID 710680.

Fracheboud D, Canevascini G. Isolation, purification, and properties of the exocellulase from Sporotrichum (Chrysosporium) thermophile. Enz Microb Technol. 1989;11(4):220-9. doi: 10.1016/0141-0229(89)90096-3.

Grogan DW. Evidence that beta-galactosidase of sulfolobus solfataricus is only one of several activities of a thermostable beta-d-glycosidase. Appl Environ Microbiol. 1991;57(6):1644-9. doi: 10.1128/aem.57.6.1644-1649.1991, PMID 16348503.

Vedamurthy AB, Mane RS. A new RoVe method to purify endophytic fungi from medicinal plants Western Ghats of Karnataka India. PCI- Approved-IJPSN. 2020;13(4):5011-9. doi: 10.37285/ijpsn.2020.13.4.7.

Gullo VP, McAlpine J, Lam KS, Baker D, Petersen F. Drug discovery from natural products. J Ind Microbiol Biotechnol. 2006;33(7):523-31. doi: 10.1007/s10295-006-0107-2, PMID 16544162.

Hahn Hagerdal B, Galbe M, Gorwa Grauslund MF, Liden G, Zacchi G. Bio-ethanol-the fuel of tomorrow from the residues of today. Trends Biotechnol. 2006;24(12):549-56. doi: 10.1016/j.tibtech.2006.10.004, PMID 17050014.

Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol. 1997;99(2):179-85. doi: 10.1016/s0091-6749(97)70093-9, PMID 9042042.

Isolauri E, Arvola T, Sutas Y, Moilanen E, Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy. 2000;30(11):1604-10. doi: 10.1046/j.1365-2222.2000.00943.x, PMID 11069570.

Bliznakov EG. Lipid-lowering drugs (statins), cholesterol, and coenzyme Q10. The Baycol case-a modern Pandora’s box. Biomed Pharmacother. 2002;56(1):56-9. doi: 10.1016/s0753-3322(01)00150-0, PMID 11905511.

Mann GV. Studies of a surfactant and cholesteremia in the Maasai. Am J Clin Nutr. 1974;27(5):464-9. doi: 10.1093/ajcn/27.5.464, PMID 4596028.

Shaper AG, Jones KW, Jones M, Kyobe J. Serum lipids in three nomadic tribes of northern Kenya. Am J Clin Nutr. 1963;13:135-46. doi: 10.1093/ajcn/13.3.135, PMID 14061585.

Mane RS, Khatun MJ, Khalequzzaman KM, Neela FA. Fusarium wilts controlling revealed physiological and biochemical variations in tomato cultivar. Biosc Biotech Res Comm. 2020;13(3):1576-80.



How to Cite

MANE, R. S., and A. NADAF. “BRIEF REVIEW ON THERMOPHILIC BACTERIA AND THEIR APPLICATIONS”. International Journal of Current Pharmaceutical Research, vol. 14, no. 1, Jan. 2022, pp. 15-19, doi:10.22159/ijcpr.2022v14i1.44107.



Review Article(s)