EVALUATION OF IN VITRO ANTI-UROLITHIATIC ACTIVITY OF SOLANUM TUBEROSUM ON CALCIUM OXALATE CRYSTALS
DOI:
https://doi.org/10.22159/ijcpr.2022v14i6.2051Keywords:
Urolithiasis, Solanumtuberosum, Calcium oxalate crystalAbstract
Objective: Present study was designed to evaluate the anti-urolithiatic activity of Indian species of Solanun tuberosum on calcium oxalate crystal In vitro model.
Methods: Potato powder was prepared by cutting, grinding and dried in hot air oven at 60-65 ℃. In vitro model of Calcium oxalate crystal was used.
Results: It was observed that the sample prepared from Solanumtuberosum, both potato ash as well as potato powder, had ability to act as anti-urolithical drug due to the presence of saponin and potassium.
Conclusion: From the present study, we can conclude that the sample prepared from Solanumtuberosum, had the ability to act as anti-urolithical drug and in vivo study can be carried out for further investigation.
Downloads
References
Smith DR. General urology. 9th ed. CA: Lange Medical Publication; 1978. p. 212-32.
Fowler C. The kidneys and ureters. In: Mann CV, Russel RCG, Williams NS. Editors, and Bailey Love’s short practice of surgery. 22nd ed. London: ELBS, Chapman & Hall; 1995. p. 915-39.
Friedlander AM, Braude AI. Production of bladder stones by human t mycoplasmas. Nature. 1974;247(5435):67-9. doi: 10.1038/247067b0.
Robertson WG, Davison CS, Grunfeld JP, Kerr D, Ritz E, editors. Aetiological factors in stone formation. Oxford textbook of Clinical Nephrology. 1992;3:1846-82.
Wolf JS. Nephrolithiasis; 2004. Available from: https://www.emedicne.com/MED/topic1600htm. [Last accessed on 15 Nov 2005]
Brent J. Current management of ethylene glycol poisoning. Drugs. 2001;61(7):978-88.
Jarald EE, Kushwah P, Edwin S, Asghar S, Patni SA. Effect of unex on ethylene glycol-induced urolithiasis in rats. Indian J Pharmacol. 2011 July-Aug;43(4):466-8. doi: 10.4103/0253-7613.83124, PMID 21845008.
https://en.org/wiki/potato.wikipedia. [Last accessed on 15 May 2022]
Khandelwal KR. Practical pharmacognosy techniques and experiments. 12th ed. Nirali Prakashan; 2004. p. 149-56.
https://himalayawellness.in/products/cystone-tablets?variant=30300905865315. [Last accessed on 02 May 2022]
https://www.1mg.com/otc/himalaya-cystone-tablet-otc169306. [Last accessed on 02 May 2022]
Ramalingam SR, Sarkaraisamy P, Seeni P. In vitro effect of cystone against calcifying microorganisms isolated from human kidney stone. Int J Pharm Sci Res. doi: 10.13040/IJPSR.0975-8232.5(9).3952-56.
Phatak RS, Hendre AS. In vitro antiurolithiatic activity of Kalanchoe pinnata extract. Int J Pharmacogn Phytochem Res. 2015;7(2):275-9.
Gov India Minist Health Fam Welf Indian Pharmacopoeia. 8th ed. Jan 2018. The Indian Pharmacopeia Commission; 2018. p. 888.
Sasidharan H, Mallya SV, Suchitra P, Kumar KNS. In vitro evaluation of scoparia dulcis linn. for anti-urolithiatic activity. J Phytopharmacol. 2018;7(3):285-7. doi: 10.31254/ phyto.2018.7309.
Government of Indian ministry of Indian Health and family welfare, Indian pharmacopoeia. Vol. II P to Z Controller Delhi publication; 1996.
Published
How to Cite
Issue
Section
Copyright (c) 2022 GOJARE SNEHAL A., PATHARE AMRUTA, SINGH SHREYALIJAY, DAPHAL NIKITA
This work is licensed under a Creative Commons Attribution 4.0 International License.