• WAGHMARE SWEETI M. Department of Pharmaceutical Chemistry, Shantiniketan College of Pharmacy, Dhotre (BK), Ahmednagar 414304
  • MANCHARE AKANKSHA M. Department of Pharmaceutical Chemistry, Shantiniketan College of Pharmacy, Dhotre (BK), Ahmednagar 414304
  • SHAIKH AVESH Y. Department of Pharmaceutical Chemistry, Shantiniketan College of Pharmacy, Dhotre (BK), Ahmednagar 414304
  • DIKSHA RAUT G. Department of Pharmaceutical Chemistry, Shantiniketan College of Pharmacy, Dhotre (BK), Ahmednagar 414304



Quinazolinone, Antibacterial, Diuretic, Antifungal, Antitumor, Anticancer, Anti-diabetics, Antihypertensive, Anti-malarial


The heterocyclic compounds have a great importance in medicinal chemistry. Quinazolinone is a heterocyclic chemical compound. A quinazolinone with a carbonyl group in the C4N2 ring. The two isomers are possible: 2-Quinazolinone and 4-Quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry. Quinazolinone derivatives were reported to possess analgesic and anti-inflammatory activity, Antibacterial, Diuretic, Antihypertensive, Anti-diabetics, Anticancer, Antitumor, Anti-fungal, Anti-malarial, Anti-protozoal agent and many other biological Action. This skeleton is an important pharmacophore considered as a privileged structure.


Download data is not yet available.


Connolly DJ, D Causack, T PO’sullivan, PJ Guiry. Synthesis of quinazolineandquinazolinone. Tetrahedron. 2005;61(43):10153-202.

Mhaske SB, Argade NP. The chemistry of recently isolated naturally occurring quinazolinone alkaloids. Tetrahedron. 2006;62(42):9787-826. doi: 10.1016/j.tet.2006.07.098.

Abida P Nayyar, M Arpanarana. An updated review: newer quinazoline derivatives under clinical trial. International Journal of Pharmaceutical and Biological Archive. 2011;2(6):1651-7.

Rajput R, Mishra AP. A review on the biological activity of quinazolinones. Int J Pharm Pharm Sci. 2012;4(2):66-70.

Osol A, JE Hoover. Remington,s pharmaceutical science. 15th ed. Easton Pennsylvania: Mack publishing Co; 1975. p. 870.

Armarego WLF. A text book of Quinazolines; 1963.

Budaviri S. editor. The merckIndex. An Encyclopedia of chemical drug, and Biologycal. White house Station, NJ. Merck and CO, Inc; 1996. p. 1385.

Vijayakumar B, Prasanthi P, Teja KM. Quinazoline derivatives and pharmacological activities: a review. Int J Med Chem Anal. 2013;3(1):10-21.

Pati B, Banerjee S. Quinazolines: an illustrated review journal of advanced pharmacy. Educ Res. 2013;3(3):136-51.

Patel NB, Patel JC. Synthesis and antimicrobial activity of schiff bases and 2-azetidinones derived from quinazolin-4(3H)-one. Arab J Chem. 2011;4(4):403-11. doi: 10.1016/j.arabjc.2010.07.005.

Alafeefy AM, El-Azab AS, Mohamed MA, Bakhat MA, Abdel Hamid SG. Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening. J Saudi Chem Soc. 2011;15(4):319-25. doi: 10.1016/j.jscs.2011.07.005.

Kunes J, Bazant J, Pour M, Waisser K, Slosarek M, Janota J. Quinazoline derivatives with antitubercular activity. Farmaco. 2000;55(11-12):725-9. doi: 10.1016/s0014-827x(00)00100-2, PMID 11204949.

MSM, MKI, AMA, SGA, AMM. Synthesis and anti-inflammatory evaluation of some new quinazoline derivatives. Int J Pharmacol. 2005;1(3):261-6. doi: 10.3923/ijp.2005.261.266.

Archana, Srivastava VK, Kumar A. Synthesis of some newer derivatives of substituted quinazolinonyl-2-oxo/thiobarbituric acid as potent anticonvulsant agents. Bioorg Med Chem. 2004;12(5):1257-64. doi: 10.1016/j.bmc.2003.08.035, PMID 14980637.

Kabri Y, Azas N, Dumètre A, Hutter S, Laget M, Verhaeghe P. Original quinazoline derivatives displaying antiplasmodial properties. Eur J Med Chem. 2010;45(2):616-22. doi: 10.1016/j.ejmech.2009.11.005, PMID 19926173.

Armarego WL. The chemistry of heterocyclic compound fused pyrimidines; 1967.

Agarwal KC, Sharma V, Shakya N, Gupta S. Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents. Bioorg Med Chem Lett. 2009;19(18):5474-7. doi: 10.1016/j.bmcl.2009.07.081, PMID 19692240.

Kohli D, Hashim SR, Vishal S, Sharma M, Singh AK. Synthesis and antibacterial activity of quinazolinone derivatives. Int J Pharm Pharm Sci. 2009;1:163-9.

Omar A, Fattah MF, Emad MM, Neama MI, Mohsen MK. Synthesis of some new quinazolin-4-one derivatives and evaluation of their antimicrobial and antiinflammatory effects. Acta Pol Pharm Drug Res. 2008;65(1):11-20.

Gursoy A, Terzioglu N. Synthesis and isolation of new regioisomeric 4-thiazolidinones and their anticonvulsant activity. Turk J Chem. 2005;29(3):247-54.

Balakumar C, Lamba P, Kishore DP, Narayana BL, Rao KV, Rajwinder K. Synthesis, anti-inflammatory evaluation and docking studies of some new fluorinated fused quinazolines. Eur J Med Chem. 2010;45(11):4904-13. doi: 10.1016/j.ejmech.2010.07.063, PMID 20800934.



How to Cite

M., W. S., M. A. M., S. A. Y., and D. R. G. “BIOLOGICAL ACTIVITY OF QUINAZOLINONE DERIVATIVES: A REVIEW”. International Journal of Current Pharmaceutical Research, vol. 15, no. 1, Jan. 2023, pp. 15-18, doi:10.22159/ijcpr.2023v15i1.2074 .



Review Article(s)