A CRITICAL REVIEW AND SIGNIFICANCE OF LIPID-BASED AYURVEDIC DOSAGE FORMS GHRITA AND TAILA: PART I-REVIEW AND STATUS

NARENDRA BHATT; MANASI DESHPANDE

doi:10.22159/ijcpr.2023v15i2.2091

Authors

NARENDRA BHATT Research and Industry, CRIA Consultants Pvt. Ltd. 15, Bachubai Building, J. Bhatankar Marg, Parel, Mumbai 400012
MANASI DESHPANDE Department of Dravyaguna Vigynan, Bharati Vidyapeeth Deemed to be University, College of Ayurved, Pune, 411043

DOI:

https://doi.org/10.22159/ijcpr.2023v15i2.2091

Keywords:

Ayurvedic dosage forms, Sneha Kalpana, Standardization, Lipid-based drug delivery

Abstract

This review discusses in detail one of the oldest lipid-based dosage form, Sneha Kalpana as described in Ayurved, one of the ancient medical systems. Here the vital constituents of plants are extracted as assimilates in lipid forms, ghrit–the clarified butter or taila–the oil. These dosage forms are administered through different routes for specific therapeutic benefits varying from topical nourishment, anti-inflammatory activity, and healing of tissue systems or even to treat serious neuro-muscular or neurological conditions. This review highlights the basic concepts of Ayurved behind the drug delivery approach and provides details of different processes of preparation or manufacture.

Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address the challenges of solubility and bioavailability of poorly water-soluble ingredients. Understanding the principles behind the processes–the right amount of heat, time, and intensity is important for standardization to ensure the availability of bio constituents. Also, it is essential to understand the relevance of therapeutic principles behind these dosage forms to choose an appropriate technological adaptation for its optimum clinical effectiveness.

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References

Bahadur RR, Shabdakalpadrum. Reprint. Vol. 5. Delhi: Nag Publisher; 2015. p. 187, 456.

Amarasimha A. With Ramasrami commentary of Bhanji Dixit. Vol. P365. New Delhi: Chaukhambha publications.

Narendra B, Manasi D, Anupama V. A critical review of standardization of ayurvedic asava-arishta part i-review and status. World J Pharm Res. 2016;5(5):1523-42.

Pandey R, Yajurved. Diamond: pocketbooks. New Delhi; 2006.

Sharma Acharya PdS, Yajurveda, Sansthan S, Bareli, chapter 2/11. Vol. 23; 1969.

Sharma Acharya PdS, Yajurveda, Sansthan S, Bareli, chapter 2/18. Vol. 25; 1969.

Eggeling J. The Shatapath Brahman, New Delhi; Max Muller, Atlantic publisher of Book; 1990.

Yajurveda Bhaishya SD. Bang lore: Bhaishya Prakashan Sanskrit. 1st ed. Vol. 2; 2006. p. 527, 192.

Vidyanath R, Niashteshwar K. A handbook of History of Ayurved. Chaukhambha Krishnadas Acad, Varanasi. 2007;P386:312.

Unnimahoday NP, Shashtri SG. Kautilya Arthashastra. ed. Vol. 1. New Delhi: Rashtriyasamakritasamasthan; 2002. p. 277.

Pandey K, Chaturvedi GN, Hindi transl. Charak samhita by Agnivesha, chaukhambha vidyabhavan varanasi. Sutra Sthana 13/9-17; 1962. p. 258-9.

Pandey K, Chaturvedi GN, Hindi Transl. Charak Samhita by agnivesha, chaukhambha vidyabhavan varanasi. Kalpa Sthana. 1962;12/101:871.

AmbikaduttShastri K. Sushrut samhita with commentary of ayurvedatattvasandipika. Chaukhambha Sanskrit Samsthan Varanasi: Sutrasthana 45/; 2003. p. 96-170.

AmbikaduttShastri K. Sushrut samhita with commentary of ayurvedatattvasandipika, chaukhambha sanskrit samsthan: Varanasi. Chikitsa Sthana. 2003;414:31/8-12.

Moreshwar Kunte A. Navare krishna ranchandra shastri collated and edited by paradakar vaidya harishashtri, ashtanga hridaya of acharya vagbhatt, kalpa sthana 6:15. 7th ed. Varanasi: Chaukhambha Orientalia; 1982. p. 774.

Mitra J. Ashtanga sangraha of vagbhata with shashilekha sanskrit commentary. Kalpa Sthana Verse. 3rd ed. Chaukhambha O Sanskrit Sereies: Varanasi Shivprasad S, editor. Vols. 08/16; 2012. p. 619-20.

Kashyapa M, Samhita K, Sthana K. Varanasi: chaukhamba samskruta samsthana. 7th ed.; 2000. p. 364, 16.

Ramvallabha S, Samhita H. Varanasi: PrachyaPrakashan; 1985. Vaidya Pandey J Harita Samhita Varanasi ChaukhambaVishvabharti. 1st ed. 2010;P456:507.

Bhel Samhita SGD. Chikitsa Sthana 11/89. Varanasi: Chaukhamba Bharti Academy; 1999. p. 285, 48.

Shrikantha MKR. Bhavaprakash of vidyotini commentary. 1st ed. Vol. Varanasi: Krishnadas Academy; 2004. p. 514-6.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda. 3rd ed. Nagpur: chapter 9: 1-211. Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 321-55.

Suresh Babu S. Yoga ratnakara: the ”A” to ”Z” classic on Āyurvedic formulations, practices, and procedures, sanskrit text with an English translation and explanatory notes. Chowkhamba Sanskrit S Off; 2005. p. 1.

Shastri KA. Bhaishajya ratnavali, chaukhambha sanskrit samsthan varanasi, 5/1283-1318. p. 130-2.

Onten CS. Chaudhary A. Study of stability (Saveeryata Avadhi) of Samanya and Panchavartita Panchtikta Ghrita, M. D. (Ayu) Dissertation. Kumar: Vikas. Varanasi: Banaras Hindu University; 2009.

Pandey K. Charak Samhita by Agnivesha, ChaukhambhaVidyabhavan: Varanasi. Sutra Sthana Hindi CGN, translator. 1962:13/9-11.

Pandey K. Charak samhita by agnivesha, chaukhambha vidyabhavan; Varanasi. Sutra Sthana Hindi CGN, Translator; 1962. p. 257.

Shastri KA. Sushrut samhita with commentary of ayurvedatattvasandipika, chaukhambha sanskrit samsthan: varanasi. Chikitsa Sthana. 2003;31/4:412.

Kunte Anna Moreshwar and Navare Krishna Ranchandra Shastri collated and edited by Paradakar Vaidya Harishashtri, Ashtanga Hridaya of Acharya Vagbhatt, Sutra Sthana 6:1. 7thedition; Varanasi, Chaukhambha Orientalia. Vol. P243; 1982.

Pandey K. Charak samhita by agnivesha, chaukhambha vidyabhavan; varanasi. Sutra Sthana Hindi CGN, Translator. 1962;257:13/14-17.

Bhavamishra, Nighantu B, Chunekar KC, editors. Haritakyadivarga. Varanasi: Chaukhamba Bharati Academy; 2013.

Vagbhata AH. Sarvanga sundari commentary of arunadattaand ayurveda rasayana of hemadri, annotated by Dr. Anna Moreshwar Kunte and Krishna Ramachandra Shastri Navre, Chaukhamba Surbharati Prakashan, Varanasi, Sutra Sthana, 5th chapter, verse: 40. Commentary; P956:73.

Bhavamishra B. Edition. Purva khanda Prof Srikantha Murthy KR, translator. Vol. 1. 6th chapter GhritaVarga, Verse-16-17. Varanasi: Krishnadas Academy. 2001;738:471.

Parishishta C, Jantava Dravya-2. Sri Chakrapanidatta, Chakradatta with the ”Vaidayaprabha” Hindi commentary and notes, introduction, indices, appendices etc. by Dr Indradeva Tripathi, Choukamba Samskrita Bhavana. 2015 ed. Vol. P542.

Agnivesa CS. Ayurveda dipika commentary of chakrapanidatta. Chikitsa Sthana, 9th Chapter, verse Vaidya Jadavaji Trikamji A, Chaukhambha Prakashan V, editors. Vols. 60-62; 2011. p. 473.

Sushrutha SS. Nibandhasangraha commentary of Sri Dalhanacharya and Nyaya Chandrika Panjika of Sri Gayadasacharya on Nidanasthana. Chaukhamba Sanskrit Sansthan Varanasi; Sutra Sthana [45th Chapter], verse: 107 Acharya VJT, Acharya NR, editors ‘ KavyaTirtha’; 2012. p. 205.

Yogaratnakara with ”Vaidyaprabha” Hindi commentary by Indradev Tripathi.

Bhatt NS, Deshpande M. A critical review and significance of ayurvedic preparation kwatha–herbal decoction. Int J Ayurvedic Med. 2020;11(2):155-64. doi: 10.47552/ijam.v11i2.1495.

Kishore P, Chintamani A. 1st ed. New Delhi: Central Ayurved and Siddha Research Center; 1999. p. 173-4.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vol. 1. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 321.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vol. 11. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 323.

Chukhambha O. Rientalia: Varanasi. Vaidayaka Paribhasha Pradeep with Hindi commentary by Dr. Indradeva Tripathi. 1st ed. Vol. P51; 1982.

Ambikadutt Shastri K. Sushrut samhita with commentary of ayurvedatattvasandipika, Chaukhambha Sanskrit Samsthan: Varanasi. Chikitsa Sthana. 2003:31/8.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 6-7. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 322.

Pandey K, Chaturvedi GN, Hindi transl. Charak Samhita by Agnivesha, Chaukhambha Vidyabhavan; Varanasi. Kalpa Sthana 12/P 101; 1962. p. 871.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vol. 144. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 343.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 88-89. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 335.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 77-81. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 333.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 99-103. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 337.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 111-114. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 339.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vol. 153. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 345.

Navre KS, Yogaratnakar VG, Jawaradhikar, Nirnay Sagar M; 1907. p. 205.

Kunte Anna Moreshwar and Navarre Krishna Ranchandra Shastri collated and edited by Paradakar Vaidya Harishashtri, Ashtanga Hridaya of Acharya Vagbhatt, Uttar Sthana 6/22-23. 7th ed. Vol. P799. Varanasi: Chaukhambha Orientalia, re print; 1982.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 146-149. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 344.

Shriradhakrushna PA. Nagpur, shri baidyanath ayurved bhavan limited. Sharangadhar samhita acharya sharangadhar madhyamkhanda 9. 3rd ed. 1984;P355:200-9.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vol. 11. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 323.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 161-164. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 347.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 44-47. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 328.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 65-68. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 331.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 159-160. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 347.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 190-192. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 252.

Shriradhakrushna PA. Sharangadhar samhita of acharya sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 73-74. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 332.

Shriradhakrushna PA. Nagpur, Shri Baidyanath Ayurved bhavan limited. Sharangadhar Samhita Acharya Sharangadhar Madhyamkhanda. 3rd ed. 1984;9:122-9, 340-1.

Shriradhakrushna PA. Nagpur, Shri Baidyanath Ayurved bhavan limited. Sharangadhar Samhita Acharya Sharangadhar Madhyamkhanda. 3rd ed. 1984;9(1245):344.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 172-174. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 349.

Ambikadutt Shastri K, Ratnavali B, Varanasi CSS: 5/1362; P 137.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vol. 171. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 349.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 59-62. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 330.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 140-143. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 343.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 184-188. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 351.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, madhyamkhanda 9. 3rd ed. Vols. 97-98. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 336.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 117-120. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 340.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vol. P326. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 26-31.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 37-40. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 327.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 20-23. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 325.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 117-120. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 340.

AmbikaduttShastri K. Sushrut Samhita with commentary of Ayurvedatattvasandipika, Chaukhambha Sanskrit Samsthan: Varanasi. Chikitsa Sthana. 2003;31(8):414.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vol. 3. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 321.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 4-5. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 322.

Pandey K. Charak Samhita by Agnivesha, Chaukhambha Vidyabhavan: Varanasi. Kalpa Sthana 12/P 101 Hindi CGN, translator; 1962. p. 871.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 6-7. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 322.

AmbikaduttShastri K, Ratnavali B, Varanasi CSS, 5/1283-84;P130.

Reddy KRC, Deo YK. Pharmaceutical standardization of Brahmi Ghrita. Int J Ayurvedic Med. 2012;3(1):16-21.

AmbikaduttShastri K, Ratnavali B, Varanasi CSS; 6/1285, P 130.

AmbikaduttShastri K, Ratnavali B, Varanasi CSS; 6/1286-1287, P 130-1.

Ranjita V. Guduchi Taila-GuduchiGhrita-Eka Kushta (psoriasis)-Rsbk-Ipgt and Ra, gau, Jamnagar; 2006.

Shrestha S, Bedarkar P, Chaudhari Swapnil GR, Patgiri BJ. Facets of sneha murchhana sanskara. Review J of Ayurveda and Holistic Medicine. Volume-V. Jan-Feb 2017(I).

Srivastava S. Acharya Sarngadhar’s Sgarngdhar Samhita, Chaukhamba Orientallie. 3rd ed. Vol. P215; 2003.

Ambikadutt Shastri K, Ratnavali B, Varanasi CSS: 5/1310-1312; P133.

Kumari S, Baghel DS. A progressive pharmaceutical review on Sneha Kalpana. Int J Green Pharm. 2018;12(1);Suppl 16.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 12-13. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 323.

Babu Sarangam SB, Vinay K, Kalpana S. A pharmaceutical review. Journal of Biological and Scientific Opinion. 2013;1(3):271-2.

Kunte Anna Moreshwar and Navarre Krishna Ranchandra Shastri collated and edited by Paradakar Vaidya Harishashtri, Ashtanga Hridaya of Acharya Vagbhatt, Kalpa Sthana 6:19-20. 7th ed. Vol. P775. Varanasi: Chaukhambha Orientalia, re print; 1982.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 14-16. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 324.

Ambikadutt Shastri K. Sushrut Samhita with commentary of Ayurvedatattvasandipika, Chaukhambha Sanskrit Samsthan: Varanasi. Chikitsa Sthana. 2003;31/11:414.

Kunte Anna Moreshwar and Navarre Krishna Ranchandra Shastri collated and edited by Paradakar Vaidya Harishashtri, Ashtanga Hridaya of Acharya Vagbhatt, Kalpa Sthana. 7th ed. Vol. P775. Varanasi: Chaukhambha Orientalia; 1982;6:19-20.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 14-16. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 324.

AmbikaduttShastri K, Ratnavali B, Varanasi CSS. 6/130 from saumya.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vols. 50-54. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 329.

Pandey K. Charak Samhita by Agnivesha, Chaukhambha Vidyabhavan: Varanasi. ChikitsaSthana Hindi CGN, translator. 1962;29/117:119-20, 744.

Rai P. Review of Sneha Kalpana W.S.R. to Ghrita. Int J Pharm Pharm Res. 2015;3(4):118-23.

Government of India, Ministry of Health and Family Welfare. Department of Indian system of Medicine and Homeopathy, Ayurved formulary of India, Part I. 2nd ed; 2003. p. 359-60.

The ayurvedic formulary of India (AFI), Part 1, 2003. Vol. P360. New Delhi: Ministry of Health and Family Welfare, Govt of India; 2003.

The Ayurved Pharmacopeia of India, Part 1, 2003. Vol. P361. New Delhi: Ministry of Health and Family Welfare, Govt of India; 2003.

Shriradhakrushna PA. Sharangadhar Samhita of Acharya Sharangadhar, Madhyamkhanda 9. 3rd ed. Vol. 1. Nagpur: Shri Baidyanath Ayurved Bhavan Limited; 1984. p. 321.

Pandey K. Charak Samhita by Agnivesha, ChaukhambhaVidyabhavan: Varanasi. Sutra Sthana Hindi CGN, translator. 1962;13/22.

Pandey K. Charak Samhita by Agnivesha, ChaukhambhaVidyabhavan: Varanasi. Sutra Sthana Hindi CGN, translator. 1962:13/18.

Shastri KA. Sushrut Samhita with commentary of Ayurvedatattvasandipika, Chaukhambha Sanskrit Samsthan: Varanasi. ChikitsaSthana. 2003;31/3:412.

Shriradhakrushna PA. Nagpur: Shri Baidyanath Ayurved bhavan limited. Sharangadhar Samhita Acharya Sharangadhar Purva Khanda. 3rd ed. 1984;P12:1/54-55.

Rameshrao Hedaoo N, Baburao Bandale M, Ingole RK. Modification in ayurvedic ancients doses forms–merits and demerits, world. J Pharm Life Sci. 2017;3(9):74-9.

Sukshma Aushadhi Kalpana Written and published by Pra. Vaidya Narahar Bhole Prabhu Prathamaawritti on. 2014;P50.

Kunte Anna Moreshwar and Navarre Krishna Ranchandra Shastri collated and edited by Paradakar Vaidya Harishashtri, Ashtanga Hridaya of Acharya Vagbhatt, chikitsaSthana 22/45. 7th ed. Vol. P732. Varanasi: Chaukhambha Orientalia; 1982.

Shastri KA, Ratnavali B, SamsthanVaranasi CS, 1981; 65/84, P 711.

Shastri KA. Sushrut Samhita with commentary of Ayurvedatattvasandipika, Chaukhambha Sanskrit Samsthan: Varanasi. ChikitsaSthana. 2003;4/28:335.

Shriradhakrushna PA. Nagpur, Shri Baidyanath Ayurved bhavan limited. Sharangadhar Samhita Acharya Sharangadhar Madhyamkhanda. 3rd ed. 1984;9(57-58):330.

Medina C, Santos Martinez MJ, Radomski A, Corrigan OI, Radomski MW. Nanoparticles: pharmacological and toxicological significance. Br J Pharmacol. 2007;150(5):552-8. doi: 10.1038/sj.bjp.0707130, PMID 17245366.

Kajaria D, Tripathi JS, Tiwari SK. Scientific basis for using medicated Ghrita (ghee) in Ayurvedic system of medicine. Ayurpharm Int J Ayur Alli Sci. 2013;2(8):254-8.

Neetu S, Anand C. A comparative study of Sneha Kalapana (paka) vis-à-vis liposome. An Int Q J Res Ayurveda. 2011;32(1):103-8.