HIGH-RESOLUTION MASS SPECTROSCOPY (HRMS)-A REVIEW

K. BHAVYASRI; S. SAILEELA; MOGILI SUMAKANTH

doi:10.22159/ijcpr.2023v15i3.3008

Authors

K. BHAVYASRI Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad-500027, India
S. SAILEELA Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad-500027, India
MOGILI SUMAKANTH Department of Pharmaceutical Chemistry, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad-500027, India

DOI:

https://doi.org/10.22159/ijcpr.2023v15i3.3008

Keywords:

TOF stands for time of flight, FTICR stands for fourier transform Ion cyclotron resonance, Orbitrap, HRMS

Abstract

High-resolution mass spectroscopy (HRMS) is a valuable method for evaluating complex and time-consuming matrices, such as human breath, and it's employed to determine the structure's precise mass and chemical structure and elemental composition and identify unknowns and a powerful analytical separation technique. High-resolution mass spectrometry (HR-MS) detects sample matrix to within 0.001 unit of atomic mass. HRMS instrumentation's enhanced resolution allows it to produce fragmentation patterns, which enhances the precision of chemical formula prediction and database comparison for allows for the detection. TOF, Orbitrap, and FT-ICR mass detectors all seem to have a great mass high resolution which may be utilised to achieve maximum data. High-resolution mass spectrometry employs devices able to accurately detecting the density of substances towards the third or fourth significant digit. The Benefit of HR-MS the effectiveness of the approach in the evaluation of complicated mixtures to offer the high peak load required to deliver the accurate molecular weight of the subcomponents. The highest resolution is typically seen in FTICR mass spectrometers. HRMS has transformed how we approach the issue of identifying and monitoring pharmaceutical residues in sophisticated biological materials.

Downloads

Download data is not yet available.

References

Xian F, Hendrickson Alon CL, Marshall G. Amsterdam High-resolution mass spectrometry. 2nd ed. Amsterdam: Elsevier; 2021.

Edward H. Drug-like properties: concepts, Structure Design and method. 3rd ed. Berlin: Springer; 2008.

Walter Korfmacher. MS for drug metabolism and pharmaceuticals. 14th ed United States: Annamaria; 2009.

Bhavya Sri K, Begum S, Swethasri R, Mogili. Sumakanth: Raman spectroscopy in reverse engineering. J Pharm Sci Res. 2022;14(7):776-82.

Bhavyasri K, Dhana Lakshmi R. Swethasri: surface-enhanced Raman spectroscopy. Panacea Journal of Pharmacy and Pharmaceutical Sciences. 2019;8(1):1-7.

Swethasri R, Bhavyasri K, Soundarya P. Thin layer chromatography surface-enhanced Raman spectroscopy. Universal Review-Journal. 2019;8(4):1374-9.

Gauglitz G, Moore DS. editors. Handbook of spectroscopy. Weinheim: Wiley-Vch Press; 2014 May 5.

Howe I, Williams DH, Bowen RD. Mass spectrometry principles and applications. New York: McGraw-Hill Inc; 1981.

Khagga Bhavyasri, Fatima A, Swethasri R, Sumakanth M. Role of LC-MS in pharmacokinetic and pharmacodynamic studies in bioanalysis: a review. J Glob Trends Pharm Sci. 2021;12(1):8887-91.

Bhavyasri K, Mounika G. Capillary electrophoresis-mass spectrometry (CE-MS) and it’s applications–a review. International J Sci Res Rev. 2019;8(2):3161-76.

Cech NB, Enke CG. Practical implications of some recent studies in electrospray ionization fundamentals. Mass Spectrom Rev. 2001;20(6):362-87. doi: 10.1002/mas.10008, PMID 11997944.

Bhavyasri K, Samreen Begum M. Sumakanth: 2-dimensional gas chromatography-mass spectroscopy: a review. Int J Pharm Sci Rev Res. 2022;76(1):140-50.

Bhavyasri K, Reddy ED, Rambabu D. Gas chromatography-mass spectrometry (GC-MS) and it’s applications–a review. Int J Res Anal Rev. 2019;6(1):456-65.

Romero Gonzalez R, Garrido Frenich A. Applications in high-resolution mass spectrometry: food safety and pesticide. 5th ed. Russia: Antonia Garrido Frenich; 2005.

Sreeraj Gopi, A Amal Raj, Shintu Jude. High-resolution mass spectrometry: instrumentation in general. 1st ed Sydney (AU). Federation Press; 2002.

Verentchikov AN, Ens W, Standing KG. Reflecting time-of-flight mass spectrometer with an electrospray ion source and orthogonal extraction. Anal Chem. 5th ed. Chichester, England: John Wiley & Sons; 2008.

Lee HN, Marshall AG. Theoretical maximal precision for mass-to-charge ratio, amplitude, and width measurement in ion-counting mass analyzers. Anal Chem. 4th ed. Brisbane: Post Pressed; 2006.

Comisarow MB. Frequency-sweep: fourier transform ion cyclotron resonance spectroscopy. 7th ed. Philadelphia: Lippincott Williams; 2005.

Julian RK Jr, Cooks RG. Broadband: excitation in the quadrupole ion trap mass spectrometer using shaped pulses with the inverse fourier transform. 3rd ed. Edinburgh: Bailliere Tindall; 2011.

Herbert CG, Johnstone RAW, Basics MS. 4th ed. Boca Raton: CRC Press; 2002. de Hoffmann E, Stroobant V. Mass spectrometry: principles and applications. 3rd ed Khinshasa: Wiley; 2001.

Rossi DT, Micheal Sinz. Mass spectrometry in drug discovery. 8th ed. Boca Raton: CRC Press; 2001.

Pramanik BN, Ganguly AK, Gross ML. Applied electrospray mass spectrometry: practical spectroscopy. 2nd ed. Khartoum: Jeonju University Communications; 2002.

Pramanik B, Chen G. Protein and peptide mass spectrometry in drug discovery. 3rd ed. Johannesburg: C. Kingsley Publishers; 2011.