HIGH-RESOLUTION MASS SPECTROSCOPY (HRMS)-A REVIEW

Authors

  • K. BHAVYASRI Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad-500027, India
  • S. SAILEELA Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad-500027, India
  • MOGILI SUMAKANTH Department of Pharmaceutical Chemistry, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad-500027, India

DOI:

https://doi.org/10.22159/ijcpr.2023v15i3.3008

Keywords:

TOF stands for time of flight, FTICR stands for fourier transform Ion cyclotron resonance, Orbitrap, HRMS

Abstract

High-resolution mass spectroscopy (HRMS) is a valuable method for evaluating complex and time-consuming matrices, such as human breath, and it's employed to determine the structure's precise mass and chemical structure and elemental composition and identify unknowns and a powerful analytical separation technique. High-resolution mass spectrometry (HR-MS) detects sample matrix to within 0.001 unit of atomic mass. HRMS instrumentation's enhanced resolution allows it to produce fragmentation patterns, which enhances the precision of chemical formula prediction and database comparison for allows for the detection. TOF, Orbitrap, and FT-ICR mass detectors all seem to have a great mass high resolution which may be utilised to achieve maximum data. High-resolution mass spectrometry employs devices able to accurately detecting the density of substances towards the third or fourth significant digit. The Benefit of HR-MS the effectiveness of the approach in the evaluation of complicated mixtures to offer the high peak load required to deliver the accurate molecular weight of the subcomponents. The highest resolution is typically seen in FTICR mass spectrometers. HRMS has transformed how we approach the issue of identifying and monitoring pharmaceutical residues in sophisticated biological materials.

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Published

15-05-2023

How to Cite

BHAVYASRI, K., S. SAILEELA, and M. SUMAKANTH. “HIGH-RESOLUTION MASS SPECTROSCOPY (HRMS)-A REVIEW”. International Journal of Current Pharmaceutical Research, vol. 15, no. 3, May 2023, pp. 9-13, doi:10.22159/ijcpr.2023v15i3.3008.

Issue

Section

Review Article(s)