A REVIEW ON COMMON HAZARDS OF STEROIDS USE IN HYPERTENSION
DOI:
https://doi.org/10.22159/ijcpr.2023v15i5.3052Keywords:
Hypertension, Steroid, Hazard effects, Aldosterone, Prednisone, DexamethasoneAbstract
Since hypertension raises the risk of cardiovascular disease and other consequences, it must be considered when deciding on a patient's course of treatment. Hypertension is the most dangerous adverse effect of corticosteroid use. Corticosteroid treatments, generally known as steroids or anti-inflammatory pharmaceuticals, are used to treat a variety of diseases. They differ from anabolic steroids, which some people often use illicitly to gain muscular mass. Despite being essential in the care of many inflammatory and immunologic illnesses, systemic corticosteroids carry a number of hazards. Osteoporosis, adrenal suppression, hyperglycemia, dyslipidemia, cardiovascular disease, Cushing's syndrome, psychiatric disorders, and immunosuppression are some of the more severe adverse effects of systemic corticosteroid therapy, particularly when taken in high dosages for lengthy periods of time. Using the most recent data as well as the authors' clinical expertise, this extensive study discusses these adverse occurrences and offers helpful advice for their prevention and management.
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Lam DS, Kwok AK, Chew S. Accelerated ocular hypertensive response to topical steroids in children. Br J Ophthalmol. 1997;81(5):422-3. doi: 10.1136/bjo.81.5.421d, PMID 9227220.
Ohji M, Kinoshita S, Ohmi E, Kuwayama Y. Marked intraocular pressure response to instillation of corticosteroids in children. Am J Ophthalmol. 1991;112(4):450-4. doi: 10.1016/s0002-9394(14)76256-7, PMID 1928249.
Biedner BZ, David R, Grudsky A, Sachs U. Intraocular pressure response to corticosteroids in children. Br J Ophthalmol. 1980;64(6):430-1. doi: 10.1136/bjo.64.6.430, PMID 7387968.
Ng JS, Fan DS, Young AL, Yip NK, Tam K, Kwok AK. Ocular hypertensive response to topical dexamethasone in children: a dose-dependent phenomenon. Ophthalmology. 2000;107(11):2097-100. doi: 10.1016/s0161-6420(00)00357-2, PMID 11054340.
Armaly MF, Becker B. Intraocular pressure response to topical corticosteroids. Fed Proc. 1965;24(6):1274-8. PMID 5853148.
Fan DS, Ng JS, Lam DS. A prospective study on ocular hypertensive and antiinflammatory response to different dosages of fluorometholone in children. Ophthalmology. 2001;108(11):1973-7. doi: 10.1016/s0161-6420(01)00781-3, PMID 11713064.
Kwok AK, Lam DS, Ng JS, Fan DS, Chew SJ, Tso MO. Ocular-hypertensive response to topical steroids in children. Ophthalmology. 1997;104(12):2112-6. doi: 10.1016/s0161-6420(97)30052-9, PMID 9400772.
Fan DS, Yu CB, Chiu TY, Wong CY, Ng JS, Pang CP. Ocular-hypertensive and anti-inflammatory response to rimexolone therapy in children. Arch Ophthalmol. 2003;121(12):1716-21. doi: 10.1001/archopht.121.12.1716, PMID 14662591.
Kaur S, Dhiman I, Kaushik S, Raj S, Pandav SS. Outcome of ocular steroid hypertensive response in children. J Glaucoma. 2016;25(4):343-7. doi: 10.1097/IJG.0000000000000209, PMID 25651206.
Bernstein HN, Mills DW, Becker B. Steroid-induced elevation of intraocular pressure. Arch Ophthalmol. 1963;70:15-8. doi: 10.1001/archopht.1963.00960050017005. PMID 13967695.
Garbe E, LeLorier J, Boivin JF, Suissa S. Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucoma. JAMA. 1997;277(9):722-7, PMID 9042844.
Cubey RB. Glaucoma following the application of corticosteroid to the skin of the eyelids. Br J Dermatol. 1976;95(2):207-8. doi: 10.1111/j.1365-2133.1976.tb00830.x, PMID 952760.
Garrott HM, Walland MJ. Glaucoma from topical corticosteroids to the eyelids. Clin Exp Ophthalmol. 2004;32(2):224-6. doi: 10.1111/j.1442-9071.2004.00787.x, PMID 15068445.
Kalina RE. Increased intraocular pressure following subconjunctival corticosteroid administration. Arch Ophthalmol. 1969;81:78-90.
Behbehani AH, Owayed AF, Hijazi ZM, Eslah EA, Al-Jazzaf AM. Cataract and ocular hypertension in children on inhaled corticosteroid therapy. J Pediatr Ophthalmol Strabismus. 2005;42(1):23-7. doi: 10.3928/01913913-20050101-03, PMID 15724895.
Smithen LM, Ober MD, Maranan L, Spaide RF. Intravitreal triamcinolone acetonide and intraocular pressure. Am J Ophthalmol. 2004;138(5):740-3. doi: 10.1016/j.ajo.2004.06.067, PMID 15531307.
Singh IP, Ahmad SI, Yeh D, Challa P, Herndon LW, Allingham RR. Early rapid rise in intraocular pressure after intravitreal triamcinolone acetonide injection. Am J Ophthalmol. 2004;138(2):286-7. doi: 10.1016/j.ajo.2004.03.001, PMID 15289140.
Gillies MC, Simpson JM, Billson FA, Luo W, Penfold P, Chua W, et al. Safety of an intravitreal injection of triamcinolone: results from a randomized clinical trial. Arch Ophthalmol. 2004;122(3):336-40. doi: 10.1001/archopht.122.3.336, PMID 15006845.
Armaly MF. Statistical attributes of the steroid hypertensive response in the clinically normal eye. Invest Ophthalmol Vis Sci. 1965;4:187-97.
Becker B. Intraocular pressure response to topical corticosteroids. Invest Ophthalmol. 1965;4:198-205. PMID 14283013.
McLean JM. Use of ACTH and cortisone. Trans-Am Ophthalmol Soc. 1950;48:293-6.
Francois J. Cortisone and eye strain. Ann Ocul (Paris). 1954;187(9):805-16. PMID 13218439.
Armaly MF. Effect of corticosteroids on intraocular pressure and fluid dynamics. I. the effect of dexamethasone in the normal eye. Arch Ophthalmol. 1963;70:482-91. doi: 10.1001/archopht.1963.00960050484010, PMID 14078870.
Armaly MF. Effect of corticosteroids on intraocular pressure and fluid dynamics. II. The effect of dexamethasone in the glaucomatous eye. Arch Ophthalmol. 1963;70:492-9. doi: 10.1001/archopht.1963.00960050494011, PMID 14078871.
Becker B, Mills DW. Corticosteroids and intraocular pressure. Arch Ophthalmol. 1963;70:500-7. doi: 10.1001/archopht.1963.00960050502012, PMID 14078872.
Becker B. Intraocular pressure response to topical corticosteroids. Invest Ophthalmol. 1965;4:198-205. PMID 14283013.
Becker B, Hahn KA. Topical corticosteroids and heredity in primary open-angle glaucoma. Am J Ophthalmol. 1964;57:543-51. doi: 10.1016/0002-9394(64)92500-0, PMID 14139296.
Gatson H, Absolon MJ, Thurtle OA, Sattar MA. Steroid responsiveness in connective tissue diseases. Br J Ophthalmol. 1983;67:487-90.
Becker B. Diabetes mellitus and primary open-angle glaucoma. The XXVII Edward Jackson Memorial Lecture. Am J Ophthalmol. 1971;71(1 Pt 1):1-16. doi: 10.1016/0002-9394(71)91088-9, PMID 5099936.
Davies TG. Tonographic survey of the close relatives of patients with chronic simple glaucoma. Br J Ophthalmol. 1968;52(1):32-9. doi: 10.1136/bjo.52.1.32, PMID 5635901.
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