ELUCIDATION OF THE BIOCHEMICAL MECHANISMS INVOLVED IN GENETIC BASIS OF LOW INCIDENCE OF DIABETES MELLITUS WITH SPECIFIC REFERENCE TO RAICA COMMUNITY OF RAJASTHAN

MILI JAIN; RAJ KUMAR VYAS

doi:10.22159/ijcpr.2023v15i5.3058

Authors

MILI JAIN Department of Biochemistry, Sardar Patel Medical College, Bikaner, Rajasthan India
RAJ KUMAR VYAS Department of Biochemistry, Sardar Patel Medical College, Bikaner, Rajasthan India

DOI:

https://doi.org/10.22159/ijcpr.2023v15i5.3058

Keywords:

ARNT gene, GLUT4 gene, Camel milk, Type-2 diabetes

Abstract

Objective: The purpose of this study is to evaluate the genotypic variables linked to lower type-2 diabetes prevalence in the raica population in Rajasthan, India.

Methods: 150 participants from outside the Raica community and 114 participants from it were recruited for this study for ARNT gene and 112 from Raica and 86 from non-Raica for GLUT4 gene. Their age and sex, body mass index, waist-to-hip ratio, and laboratory results for fasting blood glucose were all taken into account. RFLP was used for genetic study.

Results: In this study, 114 participants from Raica community and 150 from non-Raica community were recruited. There were 40 females and 74 males in Raica group and 52 females and 98 males in non-Raica group for ARNT gene. For GLUT4 gene, 112 participants were recruited from Raica and 86 participants from non-Raica community. Raica community showed lower number of participants with fasting glucose>126 mg/dl, BMI>23. Allelic distribution of ARNT and GLUT4 was also lower among Raica.

Conclusion: The examined genetic variation is equally prevalent in Raica and non-Raica individuals, diabetes circumstances included.

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