INTRA-OPERATIVE MAGNESIUM SULPHATE INFUSION DECREASES AGITATION AND PAIN IN PATIENTS UNDERGOING FUNCTIONAL ENDOSCOPIC SINUS SURGERY-A PROSPECTIVE, RANDOMIZED, CONTROLLED AND DOUBLE-BLINDED CLINICAL TRIAL

Authors

  • AMAN SAI GUNTREDDY Department of Anaesthesiology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India
  • KORRA GOPA NAIK Department of Anaesthesiology, Gayatri Vidya Parishad Medical College, Madhurawad, Visakhapatnam-530048, Andhra Pradesh, India
  • BEHARA GIRISH Department of Anaesthesiology, GITAM Institute of Medical Sciences and Research, GITAM Deemed to be University, Rushikonda, Visakhapatnam-530045, Andhra Pradesh, India

DOI:

https://doi.org/10.22159/ijcpr.2023v15i6.3087

Keywords:

Magnesium sulphate, Postoperative pain, Postoperative agitation, Endoscopic sinus surgery

Abstract

Objective: To assess the potential role of magnesium sulphate in the reduction of postoperative agitation and pain following functional endoscopic sinus surgery d in the ENT department.

Methods: A prospective, randomized controlled double blinded clinical trial was carried out on 100 patients belonging to both sexes, aged between 18-55 y, posted for functional endoscopic sinus surgery (FESS) under general anaesthesia.

Results: Intraoperative administration of magnesium sulphate in patients undergoing functional endoscopic sinus surgery decreases postoperative agitation and pain intensity; rescue analgesic consumption in the early postoperative period; and the length of stay in PACU.

Conclusion: Intravenous Magnesium sulfate decreases patient agitation and pain after functional endoscopic sinus surgery.

Downloads

References

Elsersy HE, Metyas MC, Elfeky HA, Hassan AA. Intraoperative magnesium sulphate decreases agitation and pain in patients undergoing functional endoscopic surgery: a randomised double-blind study. Eur J Anaesthesiol. 2017 Oct;34(10):658-64. doi: 10.1097/EJA.0000000000000642, PMID 28873075.

Pieters BJ, Penn E, Nicklaus P, Bruegger D, Mehta B, Weatherly R. Emergence delirium and post-operative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia. Paediatr Anaesth. 2010;20(10):944-50. doi: 10.1111/j.1460-9592.2010.03394.x, PMID 20735801.

James MF. Clinical use of magnesium infusions in anesthesia. Anesth Analg. 1992 Jan;74(1):129-36. doi: 10.1213/00000539-199201000-00021, PMID 1734773.

De Oliveira GS Jr, Castro-Alves LJ, Khan JH, McCarthy RJ. Perioperative systemic magnesium to minimize postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2013 Jul;119(1):178-90. doi: 10.1097/ALN.0b013e318297630d, PMID 23669270.

Vlajkovic GP, Sindjelic RP. Emergence delirium in children: many questions, few answers. Anesth Analg. 2007 Jan;104(1):84-91. doi: 10.1213/01.ane.0000250914.91881.a8, PMID 17179249.

Bilotta F, Gelb AW, Stazi E, Titi L, Paoloni FP, Rosa G. Pharmacological perioperative brain neuroprotection: a qualitative review of randomized clinical trials. Br J Anaesth. 2013 Jun;110Suppl 1:i113-20. doi: 10.1093/bja/aet059, PMID 23562933.

Elsery EH. Post-operative agitation in adults, factors, possible mechanisms and prevention. Anaesthesiol Clin Sci Res. 2017;1(1):1-3.

Abdulatif M, Ahmed A, Mukhtar A, Badawy S. The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anesthesia. Anaesthesia. 2013 Oct;68(10):1045-52. doi: 10.1111/anae.12380, PMID 23909742.

Ryu JH, Kang MH, Park KS, Do SH. Effects of magnesium sulphate on intraoperative anaesthetic requirements and postoperative analgesia in gynaecology patients receiving total intravenous anaesthesia. Br J Anaesth. 2008 Mar;100(3):397-403. doi: 10.1093/bja/aem407, PMID 18276652.

Koinig H, Wallner T, Marhofer P, Andel H, Horauf K, Mayer N. Magnesium sulfate reduces intra and postoperative analgesic requirements. Anesth Analg. 1998 Jul;87(1):206-10. doi: 10.1097/00000539-199807000-00042, PMID 9661575.

Kiran S, Gupta R, Verma D. Evaluation of a single dose of intravenous magnesium sulphate for prevention of postoperative pain after inguinal surgery. Indian J Anaesth. 2011 Jan;55(1):31-5. doi: 10.4103/0019-5049.76605, PMID 21431050, PMCID PMC3057242.

Yu D, Chai W, Sun X, Yao L. Emergence agitation in adults: risk factors in 2,000 patients. Can J Anaesth. 2010 Sep;57(9):843-8. doi: 10.1007/s12630-010-9338-9. PMID 20526708.

Kim SY, Kim JM, Lee JH, Song BM, Koo BN. Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery. Br J Anaesth. 2013 Aug;111(2):222-8. doi: 10.1093/bja/aet056, PMID 23524149.

Elsharnouby NM, Elsharnouby MM. Magnesium sulphate as a technique of hypotensive anaesthesia. Br J Anaesth. 2006 Jun;96(6):727-31. doi: 10.1093/bja/ael085, PMID 16670112.

Czarnetzki C, Lysakowski C, Elia N, Tramer MR. Time course of rocuronium-induced neuromuscular block after pre-treatment with magnesium sulphate: a randomised study. Acta Anaesthesiol Scand. 2010 Mar;54(3):299-306. doi: 10.1111/j.1399-6576.2009.02160.x, PMID 19919585.

Published

15-11-2023

How to Cite

GUNTREDDY, A. S., . K. G. NAIK, and B. GIRISH. “INTRA-OPERATIVE MAGNESIUM SULPHATE INFUSION DECREASES AGITATION AND PAIN IN PATIENTS UNDERGOING FUNCTIONAL ENDOSCOPIC SINUS SURGERY-A PROSPECTIVE, RANDOMIZED, CONTROLLED AND DOUBLE-BLINDED CLINICAL TRIAL”. International Journal of Current Pharmaceutical Research, vol. 15, no. 6, Nov. 2023, pp. 98-103, doi:10.22159/ijcpr.2023v15i6.3087.

Issue

Section

Original Article(s)