ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE (KAP) IN PHARMACOGENOMICS AMONG MEDICAL STUDENTS IN A TEACHING HOSPITAL-A CROSS-SECTIONAL OBSERVATIONAL STUDY

MUNGA SAGARIKA; S. SHARON SONIA; R. ASHA LATHA; PADMA SRAVANI SAGI; M. TEJASWI SAI PRIYA; S. ARUN

doi:10.22159/ijcpr.2024v16i2.4022

Authors

MUNGA SAGARIKA Department of Pharmacology, Government Medical College, Ananthapuramu, Andhra Pradesh
S. SHARON SONIA Department of Pharmacology, Government Medical College, Ananthapuramu, Andhra Pradesh
R. ASHA LATHA Department of Pharmacology, Government Medical College, Ananthapuramu, Andhra Pradesh
PADMA SRAVANI SAGI Department of Pharmacology, Government Medical College, Ananthapuramu, Andhra Pradesh
M. TEJASWI SAI PRIYA Department of Pharmacology, Government Medical College, Ananthapuramu, Andhra Pradesh
S. ARUN Department of Pharmacology, Government Medical College, Ananthapuramu, Andhra Pradesh

DOI:

https://doi.org/10.22159/ijcpr.2024v16i2.4022

Keywords:

Knowledge, Attitude, Practice, Pharmacogenomics

Abstract

Objective: Pharmacogenomics is a field of personalized medicine where individual’s genomic profile is used to guide therapeutic prescription with the goals of increasing efficacy and decreasing toxicity and progressively moving into mainstream clinical practice. Many medical students are not familiar with implications of pharmacogenomics in therapeutic effectiveness. This survey was designed and administered to assess knowledge, attitude and practices among phase 3 MBBS students (undergraduates/UGs) and postgraduates (PGs).

Methods: A Cross-sectional Observational study was conducted among Phase 3 MBBS students (n=110) and PGs (n=46). Data was collected through validated questionnaire and analyzed for their knowledge, attitudes and practices pertaining to Pharmacogenomics. SPSS version 21 and the Chi-square test was used to test the significant difference between the two groups. p value<0.05 was taken as statistically significant.

Results: From the data analyzed, about 85% of undergraduates and 89% of post-graduates have adequate knowledge on Pharmacogenomics. Both the groups had positive attitude (91% and 93%) towards Pharmacogenomics. In the cluster which evaluated the practice the positive response of agree/strongly agree were 75% and 74%, respectively. There was no significant difference between the two groups for KAP on Pharmacogenomics.

Conclusion: Awareness programmes need to be conducted to educate the undergraduates and PGs as attitude is more positive than their knowledge, and practice of pharmacogenomics. This helps to improve the choice of drug, keeping in mind the genetic profile of the patient to reduce the adverse effects, morbidity and mortality and to promote tailor-made personalized therapy.

Downloads

Download data is not yet available.

References

Arafah A, Rehman MU, Syed W, Babelghaith SD, Alwhaibi A, Al Arifi MN. Knowledge, attitude and perception of pharmacy students towards pharmacogenomics and genetics: an observational study from king Saud university. Genes (Basel). 2022 Jan 29;13(2):269. doi: 10.3390/genes13020269, PMID 35205314.

Hundertmark ME, Waring SC, Stenehjem DD, Macdonald DA, Sperl DJ, Yapel A. Pharmacist’s attitudes and knowledge of pharmacogenomics and the factors that may predict future engagement. Pharm Pract. 2020;18(3):2008. doi: 10.18549/PharmPract.2020.3.2008, PMID PubMed32922573.

Panel Sophie Veilleux. Maud Bouffard Knowledge and understanding of pharmacogenomic testing among patients and health care professionals: a scoping review. Patient Education and Counseling Elsevier. 2019;102(11):2001-9.

Cecchin E, Stocco G. Pharmacogenomics and personalized medicine. Genes. 2020;11(6):679. doi: 10.3390/genes11060679, PMID 32580376.

Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, Van Schaik RHN, Schwab M. Global pharmacogenomics within precision medicine: challenges and opportunities. Clin Pharmacol Ther. 2020;107(1):57-61. PMID 31696505.

Sharma HL, Sharma KK. Sharma and Sharma’s principles of pharmacology. 4th ed. Paras Medical Publisher; 2023. p. 134-48.

Goodmanand Gillman’s, the pharmacological basis of therapeutics. 13th ed. Vol. 72-75; 2023.

Vinothini V, Geetha K, Sarojini V, Parameswari R. A questionnaire based assessment of postgraduate’s and clinician’s view on pharmacogenomics in a tertiary care centre. Int J Sci Res. 2017;6(6):935-9.

Teresa T, Gift Ho Maja HM, Alexander Earnest. Prioritizing pharmacogenomics implementation initiatives: a survey of healthcare professionals. Pers Med. 2022 Jan;19(1):15-23. doi: 10.2217/pme-2021-0061, PMID 34881640.

Yadav Birendra Birendra Kumar, Chhagan Bihari B. In: India and its importance in cancer research. Edorium J Cancer. 2017;3:10-2.

Meric Bernstam F, Ford JM, O’Dwyer PJ, Shapiro GI, McShane LM, Freidlin B. National Cancer Institute combination therapy platform trial with molecular analysis for therapy choice (ComboMATCH). Clin Cancer Res. 2023;29(8):1412-22. doi: 10.1158/1078-0432.CCR-22-3334, PMID 36662819.

Berger Michael, Mardis Elaine. The emerging clinical relevance of genomics in cancer medicine. Nat Rev Clin Oncol. 2018;15(6):353-65. doi: 10.1038/s41571-018-0002-6, PMID 29599476.

Colomer Ramon, Miranda Jesus. Usefulness and real world outcomes of next generation sequencing testing in patients with cancer: an observational study on the impact of selection based on clinical judgement. E Clinical Medicine. 2023;60:1-4. doi: 10.1016/j.eclinm.2023.102029, PMID: 37304496.