AN OVERVIEW OF SOME HERBAL ANTIDEPRESSANT PLANTS

Authors

  • TANMAYI PATIL Department of Pharmacology, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India https://orcid.org/0009-0001-8433-4328
  • MOHAN KALE Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India
  • RUTUJA KUMBHAR Department of Pharmacology, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India
  • VISHAL BODKE Department of Pharmaceutics, Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Karjat, Maharashtra, India
  • KOMAL CHAUDHARI Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Maharashtra, India

DOI:

https://doi.org/10.22159/ijcpr.2024v16i3.4064

Keywords:

Depression, GABA, CNS, Mental health, Opioid receptors, Medicinal plant

Abstract

There are numerous ways to categorize and treat depression, which is a diverse mood disease. The illness is caused by factors such as 5-HT, NA, and MAO-A inhibition and stimulation. Reduced curiosity about pleasure, feelings of inappropriate guilt or worthlessness, a drop in hunger and sexual desire, sleeplessness, and persistent suicidal thoughts are some of the symptoms. There are several synthetic medications used to treat depression, but not all of them make patients happy, and some of them may have negative side effects. Many have turned to well-liked traditional herbal remedies to avoid the negative effects of allopathic therapy. Due to their broad application, therapeutic efficacy, and little to negligible adverse effects, herbal medications are currently used worldwide. Several medicinal plants and medicines derived from these plants have shown antidepressant properties by the combined effect of their medicinal constituents.

We discuss promising novel medicinal products targets for the management of major depressive illness in this review. We address the potential antidepressant benefits of selectively targeting receptors, including opioid, G-protein-coupled, and metabotropic glutamate receptors. Since they may also have therapeutic value, we also talk about substances that target biological processes, including inflammation, the gut microbiota, the cholesterol biosynthesis pathway, and the hypothalamic-pituitary-adrenal axis. Lastly, we offer a synopsis of all the plants displayed in graphical format, together with an overview of the antidepressant plants which currently are widely accessible.

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References

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Published

15-05-2024

How to Cite

PATIL, T., M. KALE, R. KUMBHAR, V. BODKE, and K. CHAUDHARI. “AN OVERVIEW OF SOME HERBAL ANTIDEPRESSANT PLANTS”. International Journal of Current Pharmaceutical Research, vol. 16, no. 3, May 2024, pp. 1-11, doi:10.22159/ijcpr.2024v16i3.4064.

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Section

Review Article(s)