STUDY OF CLINICAL PROFILE OF PSEUDO-EXFOLIATION SYNDROME AND PSEUDO-EXFOLIATION CATARACT IN A TERTIARY HEALTH CARE HOSPITAL IN WESTERN ODISHA

Authors

  • SARITA PANIGRAHI Department of Ophthalmology, Hitech Medical College, Rourkela, India
  • TAPAS R. MISHRA Department of Pathology, VSS Medical College, Burla, India
  • PRAGNYA P. MISHRA Department of Pathology, Hitech Medical College, Rourkela, India

DOI:

https://doi.org/10.22159/ijcpr.2024v16i4.4097

Keywords:

Cataract, Glaucoma, Pseudoexfoliation (PEX) syndrome, Prevalence, Western Odisha

Abstract

Objective: The pseudo-exfoliation (PEX) syndrome is a complex disorder characterized by the deposition of fibrillary materials around the blood vessels of organs. This study was conducted with the aim of knowing the actual prevalence of PEX in Western Odisha and the characteristics of cataracts in those PEX patients.

Methods: This cross-sectional study included 340 OPD patients and was conducted between January 1, 2021, and December 31, 2022, at Hitech Medical College and Hospital. The prevalence of PEX and cataracts was studied. The data was analyzed using basic descriptive statistics and reported in frequencies and percentages.

Results: The study showed 74 patients out of 340 were diagnosed with pseudoexfoliation syndrome, with a prevalence of 23%. 42 patients (58%) were male and 32 (42%) were female, with a M: F ratio of 1.3:1. The mean age of presentation was 67 y (range 51–84 y), and the majority of patients (41%) were in the age group of 61–70 y. The increased intraocular pressure was noticed in 11 cases (15%) in our study. Two patients each had open-angle glaucoma and lens-induced glaucoma. Nuclear cataract was the most common type of cataract observed in 27% of the study group, followed by cortical cataract with nuclear sclerosis in 19% of cases.

Conclusion: It is concluded that pseudo-exfoliation syndrome is more common in males than in females, with a higher number of patients in the age group of 81 y and older. Therefore, it can be assumed that it is associated with the age factor. Nuclear cataract was the most common type of cataract observed in our study population.

Downloads

Download data is not yet available.

References

Schlotzer Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol. 2006;141(5):921-37. doi: 10.1016/j.ajo.2006.01.047, PMID 16678509.

Schlotzer Schrehardt UM, Koca MR, Naumann GO, Volkholz H. Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophthalmol. 1992;110(12):1752-6. doi: 10.1001/archopht.1992.01080240092038, PMID 1463418.

Schlötzer Schrehardt U, Kuchle M, Hofmann Rummelt C, Kaiser A, Kirchner T. Latent TGF-beta 1 binding protein (LTBP-1); a new marker for intra- and extraocular PEX deposits. Klin Monbl Augenheilkd. 2000;216(6):412-9. doi: 10.1055/s-2000-10588, PMID 10919121.

Al-Saleh SA, Al-Dabbagh NM, Al-Shamrani SM, Khan NM, Arfin M, Tariq M. Prevalence of ocular pseudoexfoliation syndrome and associated complications in Riyadh, Saudi Arabia. Saudi Med J. 2015;36(1):108-12. doi: 10.15537/smj.2015.1.9121, PMID 25630014.

Henry JC, Krupin T, Schmitt M, lauffer J, Miller E, Ewing MQ. Long-term follow-up of pseudoexfoliation and the development of elevated intraocular pressure. Ophthalmology. 1987;94(5):545-52. doi: 10.1016/s0161-6420(87)33413-x, PMID 3601370.

Konstas AG, Ringvold A. Epidemiology of exfoliation syndrome. J Glaucoma. 2018;27Suppl 1:S4-S11. doi: 10.1097/IJG.0000000000000908, PMID 29419641.

Ringvold A. Epidemiology of the pseudo-exfoliation syndrome. Acta Ophthalmol Scand Scand 1999. 1999;77(4):371-5. doi: 10.1034/j.1600-0420.1999.770401.x, PMID 10463402.

Sood NN. Prevalence of pseudoexfoliation of the lens capsule in India. Acta Ophthalmol (Copenh). 1968;46(2):211-4. doi: 10.1111/j.1755-3768.1968.tb05179.x, PMID 5755679.

Lamba PA, Giridhar A. Pseudoexfoliation syndrome (prevalence based on random survey hospital data). Indian J Ophthalmol. 1984;32(3):169-73. PMID 6335132.

Arvind H, Raju P, Paul PG, Baskaran M, Ramesh SV, George RJ. Pseudoexfoliation in South India. Br J Ophthalmol. 2003 Nov;87(11):1321-3. doi: 10.1136/bjo.87.11.1321, PMID 14609823.

Ramakrishnan R, Nirmalan PK, Krishnadas R, Thulasiraj RD, Tielsch JM, Katz J. Glaucoma in a rural population of southern India: the aravind comprehensive eye survey. Ophthalmology. 2003 Aug;110(8):1484-90. doi: 10.1016/S0161-6420(03)00564-5, PMID 12917161.

Triveni DC, Divya DD, lakshmi DN, Sirisha DG. A study of clinical spectrum of pseudo exfoliation syndrome. Trop J Ophthalmol Otolaryngol. 2019;4(5):341-8. doi: 10.17511/jooo.2019.i05.06.

Govetto A, Lorente R, Vazquez de Parga P, Rojas L, Moreno C, Lagoa F. Frequency of pseudoexfoliation among patients scheduled for cataract surgery. J Cataract Refract Surg. 2015 Jun;41(6):1224-31. doi: 10.1016/j.jcrs.2014.09.039, PMID 26100955.

Al-Shaer M, Bamashmus M, Al-Barrag A. Point prevalence of pseudoexfoliation syndrome in patients scheduled for cataract surgery in eye camps in yemen. Middle East Afr J Ophthalmol. 2010;17(1):74-7. doi: 10.4103/0974-9233.61221, PMID 20543941.

Gelaw Y, Tibebu Y. Clinical characteristics of cataract patients with pseudoexfoliation syndrome at Jimma University specialized hospital, South West ethiopia. Ethiop J Health Sci. 2012;22(1):1-6. PMID 22984326.

Idakwo U, Olawoye O, Ajayi BG, Ritch R. Exfoliation syndrome in Northern Nigeria. Clin Ophthalmol. 2018;12:271-7. doi: 10.2147/OPTH.S153298, PMID 29440869.

Joshi RS, Singanwad SV. Frequency and surgical difficulties associated with pseudoexfoliation syndrome among Indian rural population scheduled for cataract surgery: hospital-based data. Indian J Ophthalmol. 2019;67(2):221-6. doi: 10.4103/ijo.IJO_931_18, PMID 30672474.

Philip SS, John SS, Simha AR, Jasper S, Braganza AD. Ocular clinical profile of patients with pseudoexfoliation syndrome in a tertiary eye care center in South India. Middle East Afr J Ophthalmol. 2012;19(2):231-6. doi: 10.4103/0974-9233.95259, PMID 22623865.

Published

15-07-2024

How to Cite

PANIGRAHI, S., T. R. MISHRA, and P. P. MISHRA. “STUDY OF CLINICAL PROFILE OF PSEUDO-EXFOLIATION SYNDROME AND PSEUDO-EXFOLIATION CATARACT IN A TERTIARY HEALTH CARE HOSPITAL IN WESTERN ODISHA”. International Journal of Current Pharmaceutical Research, vol. 16, no. 4, July 2024, pp. 26-29, doi:10.22159/ijcpr.2024v16i4.4097.

Issue

Section

Original Article(s)