SIMULTANEOUS ESTIMATION OF LORATADINE AND AMBROXOL HYDROCHLORIDE IN BULK AND PHARMACEUTICAL FORMULATIONS BY SIMPLE UV SPECTROPHOTOMETRY
DOI:
https://doi.org/10.22159/ijcpr.2024v16i5.5057Keywords:
Loratadine, Ambroxol hydrochloride, Simultaneous estimation, ICH guidelinesAbstract
Objective: The simple, rapid, accurate, precise and cost-effective UV spectrophotometric methods have been developed and validated for simultaneous estimation of Loratadine and Ambroxol Hydrochloride in tablet dosage form.
Methods: The UV methods have been developed utilizing concept of standard addition utilizing Methanol: Water (50:50%, v/v) as a solvent. Method is estimation using simultaneous equation method at 305 nm (λmax of Loratadine) and 242 nm (λmax of Ambroxol Hydrochloride).
Results: Linearity was observed in range of 5-25 μg/ml each for Loratadine and Ambroxol Hydrochloride, respectively for methods. The correlation coefficient (r2) value was found to be values in the range of 0.9941-0.9961. The assay result of marketed formulation was found to be 99.98 % and 100.07 % of Loratadine and Ambroxol Hydrochloride.
Conclusion: The present result shows that the proposed method can be successfully implemented for estimation of Loratadine and Ambroxol Hydrochloride in bulk and its marketed formulations. Methods were statistically validated as per ICH guidelines and can be successively applied for analysis for tablets formulation.
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