EFFECT OF RANITIDINE ON HYPOGLYCAEMIC ACTIVITY OF GLIPIZIDE IN RABBITS

Authors

  • RANJEETA GHOLVE Department of Science, Maharaja Agrasen School, Memnagar, Ahmedabad, Gujarat, India
  • SAM JOHN Department of Pharmacology, Dr. Vithalrao Vikhe Patil Foundation's Medical College and Hospital, Ahmednagar-414111, Maharashtra, India
  • DHANESHWAR SHEP Troikaa Pharmaceuticals ltd, Commerce House 1, Bodakdev, Ahmedabad, Gujarat, India
  • MANISH RAMAVAT Department of Physiology, GMERS Medical College, Vadnagar, Gujarat, India

DOI:

https://doi.org/10.22159/ijcpr.2024v16i5.5069

Keywords:

Ranitidine, Glipizide, Hypoglycaemic, Blood sugar

Abstract

Objective: To study the effect of Ranitidine (H2 receptor antagonist) in combination with Glipizide on the blood sugar level in rabbits.

Methods: Six albino rabbits were taken for the study. Glipizide was administrated to each rabbit as a single drug therapy on day 1, while was co-administrated with Ranitidine to each rabbit as a combinational drug therapy on day 7. Ranitidine was administrated to each rabbit from day 2 to day 6 as a single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h.

Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 90.9, 78.4, 67.2, 60.2 and 67.5 mg% and on day 7 were 90.3, 77.01, 63.3, 55.7 and 64 mg% respectively. When mean blood sugar level on day 1 and day 7 were considered, there was a significant reduction in blood sugar level at 2, 4 and 6 h but there was no significant fall in blood sugar level at 0 and 1 hour after co-administration of Glipizide and Ranitidine.

Conclusion: Ranitidine, when co-administered with glipizide, significantly increases the hypoglycaemic action of glipizide.

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References

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Published

15-09-2024

How to Cite

GHOLVE, R., S. JOHN, D. SHEP, and M. RAMAVAT. “EFFECT OF RANITIDINE ON HYPOGLYCAEMIC ACTIVITY OF GLIPIZIDE IN RABBITS”. International Journal of Current Pharmaceutical Research, vol. 16, no. 5, Sept. 2024, pp. 76-77, doi:10.22159/ijcpr.2024v16i5.5069.

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