A SYSTEMATIC REVIEW ON ADHERENCE TO ORAL ANTIDIABETIC DRUGS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
DOI:
https://doi.org/10.22159/ijcpr.2024v16i6.5091Keywords:
Adherence, Type 2 diabetes mellitus, Oral anti diabetic drugsAbstract
Type 2 diabetes mellitus (DM) is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world and one of the main reason for this is poor adherence to oral anti-diabetic drugs, which can lead to therapy failure and increase risk of complications. So we planned this systematic review with an aim to get an adherence estimation to oral anti-diabetic drugs in type 2 diabetes mellitus patients for which a literature search was performed in pubmed, Google Scholar, scopus, and central databases to find observational studies on therapeutic adherence in users of oral anti-diabetic drugs. Our analyses showed that adherence rate to oral anti-diabetic drugs therapy ranged from 23 to 90%. This review confirms that many patients for whom diabetes medication was prescribed were poor compliers with treatment of oral anti-diabetic drugs.
Downloads
References
Singer ME, Dorrance KA, Oxenreiter MM, Yan KR, Close KL. The type 2 diabetes modern preventable pandemic and replicable lessons from the COVID-19 crisis. Prev Med Rep. 2022 Feb;25:101636. doi: 10.1016/j.pmedr.2021.101636, PMID 34909369.
Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007;27(12):2650-6. doi: 10.1161/ATVBAHA.107.153288, PMID 17932315.
Johnson SB. Methodological issues in diabetes research measuring adherence. Diabetes Care. 1992;15(11):1658-67. doi: 10.2337/diacare.15.11.1658, PMID 1468298.
Polonsky WH, Henry RR. Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors. Patient Prefer Adherence. 2016 Jul 22;10:1299-307. doi: 10.2147/PPA.S106821, PMID 27524885.
Carydias E, Tasho A, Kani C, Bacopoulou F, Stefanaki C, Markantonis SL. Systematic review and meta-analysis of the efficacy and safety of metformin and GLP-1 analogues in children and adolescents with diabetes mellitus type 2. Children (Basel). 2022;9(10):1572. doi: 10.3390/children9101572, PMID 36291508.
Egede LE, Gebregziabher M, Echols C, Lynch CP. Longitudinal effects of medication nonadherence on glycemic control. Ann Pharmacother. 2014;48(5):562-70. doi: 10.1177/1060028014526362, PMID 24586059.
DiBonaventura M, Wintfeld N, Huang J, Goren A. The association between nonadherence and glycated hemoglobin among type 2 diabetes patients using basal insulin analogs. Patient Prefer Adherence. 2014;8:873-82. doi: 10.2147/PPA.S55550, PMID 24971002.
Jha AK, Aubert RE, Yao J, Teagarden JR, Epstein RS. Greater adherence to diabetes drugs is linked to less hospital use and could save nearly $5 billion annually. Health Aff (Millwood). 2012;31(8):1836-46. doi: 10.1377/hlthaff.2011.1198, PMID 22869663.
Sendekie AK, Netere AK, Kasahun AE, Belachew EA. Medication adherence and its impact on glycemic control in type 2 diabetes mellitus patients with comorbidity: a multicenter cross sectional study in Northwest Ethiopia. Plos One. 2022;17(9):e0274971. doi: 10.1371/journal.pone.0274971, PMID 36130160.
Faisal K, Tusiimire J, Yadesa TM. Prevalence and factors associated with non-adherence to antidiabetic medication among patients at Mbarara Regional Referral Hospital Mbarara Uganda. Patient Prefer Adherence. 2022 Feb 22;16:479-91. doi: 10.2147/PPA.S343736, PMID 35228796.
Yazew KG, Walle TA. Prevalence of antidiabetic medication adherence and determinant factors in Ethiopia: a systemic review and meta-analysis. Int J Afr Nurs Sci. 2019;11:100167. doi: 10.1016/j.ijans.2019.100167.
Bagonza J, Rutebemberwa E, Bazeyo W. Adherence to anti-diabetic medication among patients with diabetes in eastern Uganda; a cross-sectional study. BMC Health Serv Res. 2015;15:168. doi: 10.1186/s12913-015-0820-5, PMID 25898973.
Mishra R, Sharma SK, Verma R, Kangra P, Dahiya P, Kumari P. Medication adherence and quality of life among type-2 diabetes mellitus patients in India. World J Diabetes. 2021;12(10):1740-9. doi: 10.4239/wjd.v12.i10.1740, PMID 34754375.
Kirkman MS, Rowan Martin MT, Levin R, Fonseca VA, Schmittdiel JA, Herman WH. Determinants of adherence to diabetes medications: findings from a large pharmacy claims database. Diabetes Care. 2015;38(4):604-9. doi: 10.2337/dc14-2098, PMID 25573883.
Sahoo J, Mohanty S, Kundu A, Epari V. Medication adherence among patients of type II diabetes mellitus and its associated risk factors: a cross-sectional study in a Tertiary Care Hospital of Eastern India. Cureus. 2022;14(12):e33074. doi: 10.7759/cureus.33074, PMID 36721541.
Mirghani HO. An evaluation of adherence to anti-diabetic medications among type 2 diabetic patients in a Sudanese outpatient clinic. Pan Afr Med J. 2019 Sep 16;34:34. doi: 10.11604/pamj.2019.34.34.15161, PMID 31762902.
Shaikh SA, Kumari J, Bahmanshiri Y. Assessing the adherence to antidiabetic medications among patients diagnosed with type 2 diabetes mellitus in Ajman UAE. Cureus. 2023;15(11):e49325. doi: 10.7759/cureus.49325, PMID 38143686.
Piragine E, Petri D, Martelli A, Calderone V, Lucenteforte E. Adherence to oral antidiabetic drugs in patients with type 2 diabetes: systematic review and meta-analysis. J Clin Med. 2023;12(5):1981. doi: 10.3390/jcm12051981, PMID 36902770.
Demoz GT, Wahdey S, Bahrey D, Kahsay H, Woldu G, Niriayo YL. Predictors of poor adherence to antidiabetic therapy in patients with type 2 diabetes: a cross-sectional study insight from Ethiopia. Diabetol Metab Syndr. 2020 Jul 16;12:62. doi: 10.1186/s13098-020-00567-7, PMID 32695232.
Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care. 2004 May;27(5):1218-24. doi: 10.2337/diacare.27.5.1218, PMID 15111553.
Ahmad NS, Ramli A, Islahudin F, Paraidathathu T. Medication adherence in patients with type 2 diabetes mellitus treated at primary health clinics in Malaysia. Patient Prefer Adherence. 2013 Jun 17;7:525-30. doi: 10.2147/PPA.S44698, PMID 23814461.
Jemal A, Abdela J. Adherence to oral antidiabetic medications among type 2 diabetic (T2DM) patients in chronic ambulatory wards of Hiwot Fana Specialized University Hospital Harar Eastern Ethiopia: a cross-sectional study. J Diabetes Metab. 2017 Jan;8(1):1000721. doi: 10.4172/2155-6156.1000721.
Published
How to Cite
Issue
Section
Copyright (c) 2024 ARVIND NARWAT, ABHINAV GOYAL, RAHUL BHATI
This work is licensed under a Creative Commons Attribution 4.0 International License.