NEUROREGENERATIVE EFFECTS OF D-α-TOCOPHEROL ON THE CRUSHED SCIATIC NERVE OF DIABETIC RATS
Abstract
ABSTRACT
Objective: This present study is designed to explore the neuroregenerative effects of d-α-tocopherol on peripheral nerve in both healthy and diabetic
rats.
Methods: 24 albino rats were divided into four groups; healthy control, diabetic control, healthy treated, and diabetic treated. Diabetes was induced
by single subcutaneous injection of alloxan (100 mg/kg). Treated groups were administered d-α-tocopherol orally, daily (200 mg/kg) for 3 weeks.
Through a mid-thigh incision, sciatic nerve was crushed with Kocher's forceps, and skin wound was closed with absorbable suture. Sciatic functional
and static indices were used to assess the functional recovery in conjunction with histological, histomorphological, and biochemical analyses at the
end of 3 weeks.
Results: It was noticed that d-α-tocopherol supplementation accelerates functional recovery, enhances the antioxidant levels, and promotes the
regeneration and extracellular matrix reorganization of peripheral nerves.
Conclusion: It is concluded that the d-α-tocopherol appears to be an optimistic option in the management of peripheral nerve crush injury in both
healthy and diabetics.
Keywords: Antioxidant, d-α-tocopherol, Diabetes, Rats, Regeneration, Sciatic nerve.
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