• GURPREET KAUR GILL Department of Pharmacy, Khalsa College of Pharmacy and Technology, Amritsar, Punjab, India.
  • SUKHJIT KAUR Department of Pharmacy, Khalsa College of Pharmacy and Technology, Amritsar, Punjab, India.


Diabetes mellitus, Microvascular complications, Dyslipidemia, Triglycerides, Hyperglycemia


Objective: The main aim of the present study was to investigate the levels of lipid and lipoproteins in causing secondary microvascular complications in diabetic patients. Patients of Type II diabetes mellitus are highly susceptible to various complications due to long-term persistence of hyperglycemic state in the body. Thus, it is imperative to study the effect of hyperglycemia on lipids as their subsequent oxidation can lead to complications such as nephropathy, neuropathy, and retinopathy in diabetics which can further lead to macrovascular complications in the body.

Methods: The diabetic patients were divided into two groups, based on the presence/absence of secondary microvascular complications, namely, nephropathy, retinopathy, and neuropathy. Two types of cases were included in the study, on the basis of duration, namely, 0–5 years and 5–10 years duration. Blood samples were collected and levels of hemoglobin and glycated hemoglobin were determined. The biochemical parameters, namely, random blood sugar, cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins (LDLs), and very LDLs were estimated.

Results: The lipid levels altered in diabetic patients, leading to the dyslipidemia and the cumulative effect of hyperglycemia and dyslipidemia leads to the oxidative stress in the body. The increased oxidation of lipids may lead to the occurrence of microvascular complications in the body. Furthermore, dyslipidemia has been found more prevalent in males as compared to females.

Conclusion: Due to the increased prevalence of diabetes in India, funding of this study would suggest that there is a need to accelerate the importance of monitoring lipid levels in diabetes. Diabetic patients should routinely monitor their glycemic status, renal, and lipid profile to avert microvascular complications associated with diabetes mellitus.


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